Chabes, Anna Lena, Pfleger, Cathie M., Kirschner, Marc W., Thelander, Lars
Ribonucleotide reductase consists of two nonidentical proteins, R1 and R2, and catalyzes the rate-limiting step in DNA precursor synthesis: the reduction of ribonucleotides to deoxyribonucleotides. A...
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
Pfleger, Cathie M., Kirschner, Marc W.
The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and specific. One key...
Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Pfleger, Cathie M., Salic, Adrian, Lee, Ethan, Kirschner, Marc W.
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1....
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
Pfleger, Cathie M., Lee, Ethan, Kirschner, Marc W.
The specificity of ubiquitin-mediated protein degradation with regards to the selection of substrates to be polyubiquitinated has only been determined rather recently. Substrate targeting by the...
Delalle, Ivana, Pfleger, Cathie M., Buff, Eugene, Lueras, Paula, Hariharan, Iswar K.
The progression of several human neurodegenerative diseases is characterized by the appearance of intracellular inclusions or cytoskeletal abnormalities. An important question is whether these...
Chabes, Anna Lena, Pfleger, Cathie M., Kirschner, Marc W., Thelander, Lars
Ribonucleotide reductase consists of two nonidentical proteins, R1 and R2, and catalyzes the rate-limiting step in DNA precursor synthesis: the reduction of ribonucleotides to deoxyribonucleotides. A...
Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Pfleger, Cathie M., Salic, Adrian, Lee, Ethan, Kirschner, Marc W.
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1....
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
Pfleger, Cathie M., Lee, Ethan, Kirschner, Marc W.
The specificity of ubiquitin-mediated protein degradation with regards to the selection of substrates to be polyubiquitinated has only been determined rather recently. Substrate targeting by the...
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
Pfleger, Cathie M., Kirschner, Marc W.
The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and specific. One key...
Delalle, Ivana, Pfleger, Cathie M., Buff, Eugene, Lueras, Paula, Hariharan, Iswar K.
The progression of several human neurodegenerative diseases is characterized by the appearance of intracellular inclusions or cytoskeletal abnormalities. An important question is whether these...
Mills, Kathryn, Daish, Tasman, Harvey, Kieran F., Pfleger, Cathie M., Hariharan, Iswar K., Kumar, Sharad
The Apaf-1 protein is essential for cytochrome c–mediated caspase-9 activation in the intrinsic mammalian pathway of apoptosis. Although Apaf-1 is the only known mammalian homologue of the...