Endocrine Disruptors and Breast Cancer (2008)
Breast cancer strikes one out of eight women in Switzerland. The increase in breast cancer incidence over the past 70 years parallels an enormous increase of man-made, persistent chemicals in our...
What signals operate in the mammary niche? (2008)
Tanos, Tamara, Brisken, Cathrin
Adult stem cells reside in a specialized microenvironment, the niche, which controls their behavior. As mammary stem cells, and consequently their niches, are still poorly defined, we look at...
Duss, Stephan, André, Sylvie, Nicoulaz, Anne-Laure, Fiche, Maryse, Bonnefoi, Hervé, Brisken, Cathrin, ...
Abstract Introduction About 70% of breast cancers express oestrogen receptor α (ESR1/ERα) and are oestrogen-dependent for growth. In contrast with the highly proliferative nature of ERα-positive...
Extended focus Fourier domain optical coherence microscopy assists developmental biology (2007)
Villiger, Martin L., Beleut, Manfred, Brisken, Cathrin, Lasser, Theo, Leitgeb, Rainer A.
We present a novel detection scheme for Fourier domain optical coherence microscopy (FDOCM). A Bessel-like interference pattern with a strong central lobe was created with an axicon lens. This...
Prolactin signaling and Stat5: going their own separate ways? (2002)
Brisken, Cathrin, Ayyanan, Ayyakkannu, Doppler, Wolfgang
Abstract Miyoshi et al . compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in...
A paracrine role for the epithelial progesterone receptor in mammary gland development
Brisken, Cathrin, Park, Sissela, Vass, Tibor, Lydon, John P., O’Malley, Bert W., Weinberg, Robert A.
Recently generated progesterone receptor (PR)-negative (PR−/−) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and...
Brisken, Cathrin, Socolovsky, Merav, Lodish, Harvey F., Weinberg, Robert
The cytokine hormones prolactin and erythropoietin mediate tissue-specific developmental outcomes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR),...
Prolactin signaling and Stat5: going their own separate ways?
Brisken, Cathrin, Ayyanan, Ayyakkannu, Doppler, Wolfgang
Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by...
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
Brisken, Cathrin, Heineman, Anna, Chavarria, Tony, Elenbaas, Brian, Tan, Jian, Dey, Sudhansu K., ...
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome...
Devgan, Vikram, Mammucari, Cristina, Millar, Sarah E., Brisken, Cathrin, Dotto, G. Paolo
In keratinocytes, the cyclin/CDK inhibitor p21WAF1/Cip1 is a direct transcriptional target of Notch1 activation; loss of either the p21 or Notch1 genes expands stem cell populations and facilitates...
Mallepell, Sonia, Krust, Andrée, Chambon, Pierre, Brisken, Cathrin
Estradiol is a major regulator of postnatal mammary gland development and thought to exert its effects through estrogen receptor α (ERα) expressed in the mammary gland stroma and epithelium....
Ayyanan, Ayyakannu, Civenni, Gianluca, Ciarloni, Laura, Morel, Catherine, Mueller, Nathalie, Lefort, Karine, ...
Wnt and Notch signaling have long been established as strongly oncogenic in the mouse mammary gland. Aberrant expression of several Wnts and other components of this pathway in human breast...
A paracrine role for the epithelial progesterone receptor in mammary gland development
Brisken, Cathrin, Park, Sissela, Vass, Tibor, Lydon, John P., O’Malley, Bert W., Weinberg, Robert A.
Recently generated progesterone receptor (PR)-negative (PR−/−) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and...
Brisken, Cathrin, Socolovsky, Merav, Lodish, Harvey F., Weinberg, Robert
The cytokine hormones prolactin and erythropoietin mediate tissue-specific developmental outcomes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR),...
Prolactin signaling and Stat5: going their own separate ways?
Brisken, Cathrin, Ayyanan, Ayyakkannu, Doppler, Wolfgang
Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by...
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
Brisken, Cathrin, Heineman, Anna, Chavarria, Tony, Elenbaas, Brian, Tan, Jian, Dey, Sudhansu K., ...
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome...
Devgan, Vikram, Mammucari, Cristina, Millar, Sarah E., Brisken, Cathrin, Dotto, G. Paolo
In keratinocytes, the cyclin/CDK inhibitor p21WAF1/Cip1 is a direct transcriptional target of Notch1 activation; loss of either the p21 or Notch1 genes expands stem cell populations and facilitates...
Mallepell, Sonia, Krust, Andrée, Chambon, Pierre, Brisken, Cathrin
Estradiol is a major regulator of postnatal mammary gland development and thought to exert its effects through estrogen receptor α (ERα) expressed in the mammary gland stroma and epithelium....
Ayyanan, Ayyakannu, Civenni, Gianluca, Ciarloni, Laura, Morel, Catherine, Mueller, Nathalie, Lefort, Karine, ...
Wnt and Notch signaling have long been established as strongly oncogenic in the mouse mammary gland. Aberrant expression of several Wnts and other components of this pathway in human breast...
Duss, Stephan, André, Sylvie, Nicoulaz, Anne-Laure, Fiche, Maryse, Bonnefoi, Hervé, Brisken, Cathrin, ...
Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development
Ciarloni, Laura, Mallepell, Sonia, Brisken, Cathrin
Most mammary gland development occurs after birth under the control of systemic hormones. Estrogens induce mammary epithelial cell proliferation during puberty via epithelial estrogen receptor α...