Deguara, Jean, Burnand, Kevin G., Berg, Jonathan, Green, Peter, Lewis, Cathryn M., Chinien, Ganesh, ...
Zhou, Kaixin, Dempfle, Astrid, Arcos-Burgos, Mauricio, Bakker, Steven C., Banaschewski, Tobias, Biederman, Joseph, ...
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that...
Tremelling, Mark, Anderson, Carl A, Gwilliam, Rhian, Bumpstead, Suzannah, Prescott, Natalie J, ...
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative...
Wim J. Meulemans, Cathryn M. Lewis, Dorret I. Boomsma, Catherine A. Derom, Jakobus F. Orlebeke, ...
The inheritance of spontaneous dizygotic (DZ) twinning was investigated in 1,422 three-generation pedigrees ascertained through mothers of spontaneous DZ proband twins. DZ twinning was modelled as a...
Chiodini, Benedetta D., Franzosi, Maria Grazia, Barlera, Simona, Signorini, Stefano, Lewis, Cathryn M., D'Orazio, Andria, ...
Aims Controversy exists with regard to the influence of APOE polymorphisms on coronary heart disease development and on the efficacy of statin treatment. We investigated the relationship between...
Cardon, Lon R, Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P, ...
There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study...
Ioannidis, John P. A., Ng, Mandy Y., Sham, Pak C., Zintzaras, Elias, Lewis, Cathryn M., Deng, Hong-Wen, ...
Several genome-wide scans have been performed to detect loci that regulate BMD, but these have yielded inconsistent results, with limited replication of linkage peaks in different studies. In an...
Ioannidis, John P. A., Ng, Mandy Y., Sham, Pak C., Zintzaras, Elias, Lewis, Cathryn M., Deng, Hong-Wen, ...
Several genome-wide scans have been performed to detect loci that regulate BMD, but these have yielded inconsistent results, with limited replication of linkage peaks in different studies. In an...
Deguara, Jean, Burnand, Kevin G., Berg, Jonathan, Green, Peter, Lewis, Cathryn M., Chinien, Ganesh, ...
Matrix metalloproteinase 3 (MMP3), is over expressed in the wall of abdominal aortic aneurysms (AAA), while inactivation of the gene expressing this enzyme is associated with reduced aneurysm...
Novel IL10 gene family associations with systemic juvenile idiopathic arthritis (2006)
Fife, Mark S, Gutierrez, Ana, Ogilvie, Emma M, Stock, Carmel JW, Samuel, Jane M, Thomson, Wendy, ...
Abstract Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA...
GSMA: software implementation of the genome search meta-analysis method (2005)
Pardi, Fabio, Levinson, Douglas F., Lewis, Cathryn M.
Meta-analysis can be used to pool results of genome-wide linkage scans. This is of great value in complex diseases, where replication of linked regions occurs infrequently. The genome search...
Meta-analysis of genome scans of age-related macular degeneration (2005)
Fisher, Sheila A., Abecasis, Goncalo R., Yashar, Beverly M., Zareparsi, Sepideh, Swaroop, Anand, Iyengar, Sudha K., ...
A genetic contribution to the development of age-related macular degeneration (AMD) is well established. Several genome-wide linkage studies have identified a number of putative susceptibility loci...
GSMA: software for analysis of the genome-search meta-analysis method (2005)
Pardi, Fabio, Levinson, Douglas F., Lewis, Cathryn M.
Meta-analysis can be used to pool results of genome-wide linkage scans. This is of great value in complex diseases, where replication of linked regions occurs infrequently. The Genome Search...
Meta-Analysis of Genome Scans of Age-Related Macular Degeneration (2005)
Fisher, Sheila A, Abecasis, Goncalo R, Yashar, Beverly M, Zareparsi, Sepideh, Swaroop, Anand, Iyengar, Sudha K, ...
A genetic contribution to the development of age-related macular degeneration (AMD) is well established. Several genome-wide linkage studies have identified a number of putative susceptibility loci...
Koivukoski, Liisa, Fisher, Sheila A., Kanninen, Timo, Lewis, Cathryn M., Von Wowern, Fredrik, Hunt, Steven, ...
Abstract is not available
GENETICS OF INFLAMMATORY BOWEL DISEASE: PROGRESS AND PROSPECTS (2004)
Mathew, Christopher G., Lewis, Cathryn M.
Strong epidemiological evidence for a genetic contribution to pathogenesis in inflammatory bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major clinical...
Van Heel, David A., Fisher, Sheila A., Kirby, Andrew, Daly, Mark J., Rioux, John D., Lewis, Cathryn M., ...
Crohn's disease and ulcerative colitis (the inflammatory bowel diseases) have a strong genetic component. Although over 20 putative susceptibility loci have been identified by individual genome...
Koivukoski, Liisa, Fisher, Sheila A., Kanninen, Timo, Lewis, Cathryn M., Von Wowern, Fredrik, Hunt, Steven, ...
Individual genome-wide scans of blood pressure (BP) and hypertension (HT) have shown inconsistent results. The aim of this study was to investigate whether there was any consistent evidence of...
Koivukoski, Liisa, Fisher, Sheila A., Kanninen, Timo, Lewis, Cathryn M., Von Wowern, Fredrik, Hunt, Steven, ...
Individual genome-wide scans of blood pressure (BP) and hypertension (HT) have shown inconsistent results. The aim of this study was to investigate whether there was any consistent evidence of...
Genetics of inflammatory bowel disease: progress and prospects (2004)
Mathew, Christopher G., Lewis, Cathryn M.
Strong epidemiological evidence for a genetic contribution to pathogenesis in inflammatory bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major clinical...
Van Heel, David A., Fisher, Sheila A., Kirby, Andrew, Daly, Mark J., Rioux, John D., Lewis, Cathryn M.
Crohn's disease and ulcerative colitis (the inflammatory bowel diseases) have a strong genetic component. Although over 20 putative susceptibility loci have been identified by individual genome...
GENETICS OF INFLAMMATORY BOWEL DISEASE: PROGRESS AND PROSPECTS (2004)
Mathew, Christopher G., Lewis, Cathryn M.
Strong epidemiological evidence for a genetic contribution to pathogenesis in inflammatory bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major clinical...
Van Heel, David A., Fisher, Sheila A., Kirby, Andrew, Daly, Mark J., Rioux, John D., Lewis, Cathryn M., ...
Crohn's disease and ulcerative colitis (the inflammatory bowel diseases) have a strong genetic component. Although over 20 putative susceptibility loci have been identified by individual genome...
Koivukoski, Liisa, Fisher, Sheila A., Kanninen, Timo, Lewis, Cathryn M., Von Wowern, Fredrik, Hunt, Steven, ...
Individual genome-wide scans of blood pressure (BP) and hypertension (HT) have shown inconsistent results. The aim of this study was to investigate whether there was any consistent evidence of...
Byng, Martyn C, Fisher, Sheila A, Lewis, Cathryn M, Whittaker, John C
Abstract We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the...
Apicella, Carmel, Andrews, Lesley, Hodgson, Shirley V, Fisher, Sheila A, Lewis, Cathryn M, Solomon, Ellen, ...
Abstract Introduction Ancestral mutations in BRCA1 and BRCA2 are common in people of Ashkenazi Jewish descent and are associated with a substantially increased risk of breast and ovarian cancer....
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia (2003)
Lewis, Cathryn M, Levinson, Douglas F, Wise, Lesley H, DeLisi, Lynn E, Straub, Richard E, Hovatta, Iiris, ...
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Genome scan meta-analysis of schizophrenia and bipolar disorder, Part III : bipolar disorder (2003)
Segurado, Ricardo, Detera-Wadleigh, Sevilla D, Ekholm, Jenny, Donald, Jennifer A, Levinson, Douglas F, Lewis, Cathryn M, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Genome scan meta-analysis of schizophrenia and bipolar disorder, Part III : bipolar disorder (2003)
Segurado, Ricardo, Detera-Wadleigh, Sevilla D, Ekholm, Jenny, Donald, Jennifer A, Levinson, Douglas F, Lewis, Cathryn M, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Genome scan meta-analysis of schizophrenia and bipolar disorder, Part III : bipolar disorder (2003)
Segurado, Ricardo, Detera-Wadleigh, Sevilla D, Ekholm, Jenny, Donald, Jennifer A, Levinson, Douglas F, Lewis, Cathryn M, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Genetic association studies: Design, analysis and interpretation (2002)
This paper provides a review of the design and analysis of genetic association studies. In case control studies, the different contingency tables and their relationships to the underlying genetic...
Genomic mismatch scanning in pedigrees (1994)
THOMAS, ALUN, SKOLNICK, MARK H., LEWIS, CATHRYN M.
The new method of genomic mismatch scanning allows the high-resolution mapping of identity by descent on the chromosomes of two related individuals. Modelling recombinant events as a continuous...
Goldgar, David E., Fields, Patty, Lewis, Cathryn M., Tran, Thao D., Cannon-Albright, Lisa A., Ward, John H., ...
Background Mutation of a specific, but as yet unidentified, gene BRCA1 on chromosome 17q results in increased susceptibility to breast and ovarian cancer. It is important to know the effects of this...
The use of graph theory techniques to investigate genealogical structure (1992)
The correspondence between a graph and a genealogy is used to apply techniques from the field of graph theory to genetic epidemiology. A method is described for discarding the individuals and...
Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, ...
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence...
Apicella, Carmel, Andrews, Lesley, Hodgson, Shirley V, Fisher, Sheila A, Lewis, Cathryn M, Solomon, Ellen, ...
Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, ...
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence...
Apicella, Carmel, Andrews, Lesley, Hodgson, Shirley V, Fisher, Sheila A, Lewis, Cathryn M, Solomon, Ellen, ...
Genetic Evidence for Interaction of the 5q31 Cytokine Locus and the CARD15 Gene in Crohn Disease
Mirza, Muddassar M., Fisher, Sheila A., King, Kathy, Cuthbert, Andrew P., Hampe, Jochen, Sanderson, Jeremy, ...
A common haplotype spanning 250 kb in the cytokine gene cluster on chromosome 5q31 has recently been reported to be strongly associated with Crohn disease (CD) in Canadian families. We have...
Ruddy, Deborah M., Parton, Matthew J., Al-Chalabi, Ammar, Lewis, Cathryn M., Vance, Caroline, Smith, Bradley N., ...
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset disease in which motor neurons in the brain and spinal cord degenerate by largely unknown mechanisms. ALS is familial (FALS) in 10% of...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis
Levinson, Douglas F., Levinson, Matthew D., Segurado, Ricardo, Lewis, Cathryn M.
This is the first of three articles on a meta-analysis of genome scans of schizophrenia (SCZ) and bipolar disorder (BPD) that uses the rank-based genome scan meta-analysis (GSMA) method. Here we used...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Lewis, Cathryn M., Levinson, Douglas F., Wise, Lesley H., DeLisi, Lynn E., Straub, Richard E., Hovatta, Iiris, ...
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Segurado, Ricardo, Detera-Wadleigh, Sevilla D., Levinson, Douglas F., Lewis, Cathryn M., Gill, Michael, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Novel IL10 gene family associations with systemic juvenile idiopathic arthritis
Fife, Mark S, Gutierrez, Ana, Ogilvie, Emma M, Stock, Carmel JW, Samuel, Jane M, Thomson, Wendy, ...
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA (sJIA), which...
Byng, Martyn C, Fisher, Sheila A, Lewis, Cathryn M, Whittaker, John C
We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum...
Searching for Genotype-Phenotype Structure: Using Hierarchical Log-Linear Models in Crohn Disease
Chapman, Juliet M., Onnie, Clive M., Prescott, Natalie J., Fisher, Sheila A., Mansfield, John C., Mathew, Christopher G., ...
There has been considerable recent success in the detection of gene-disease associations. We consider here the development of tools that facilitate the more detailed characterization of the effect of...