Cecilia Osterholm

Anti-LFA-1 Improves Pig Islet Xenograft Function in Diabetic Mice When Long-Term Acceptance Is Induced by CTLA4Ig/Anti-CD40L. (2007)

Kumagai-Braesch, Makiko, Ekberg, Henrik, Wang, Feng, Osterholm, Cecilia, Ehrnfelt, Cecilia, Sharma, Amit, ...

Abstract is not available

CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice. (2002)

Malm, Helene, Corbascio, Matthias, Osterholm, Cecilia, Cowan, Shannon, Larsen, Christian P, Pearson, Thomas C, ...

BACKGROUND: It was recently shown that some strains of mice are capable of rejecting transplants independently of B7 and CD40L signaling and that this rejection is mediated by CD8(+) T cells. LFA-1...

Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice. (2002)

Corbascio, Matthias, Mahanty, Harish, Osterholm, Cecilia, Qi, Zhongquan, Pearson, Thomas C, Larsen, Christian P, ...

BACKGROUND: Blockade of CD40 ligand (CD40L; CD154, gp39) is a potential treatment for autoimmune disease and allograft rejection. However, CD40L-/- mice are capable of mobilizing cellular immune...

CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely. (2002)

Corbascio, Matthias, Ekstrand, Helene, Osterholm, Cecilia, Qi, Zhongquan, Simanaitis, Mecislovas, Larsen, Christian P, ...

CTLA4Ig and anti-LFA-1 are members of a new generation of immunomodulatory drugs which inhibit important signaling pathways in T cell activation. Both substances target molecules which have pivitol...