DNA immunization: effect of secretion of DNA-expressed hemagglutinins on antibody responses (1999)
Torres, Celia Aurora Tiglao, Yang, Kejian, Mustafa, Farah, Robinson, Harriet L.
DNA vaccines expressing plasma membrane and secreted forms of the influenza and measles virus hemagglutinins (HAs) have been used to evaluate the effect of secretion on DNA-raised antibody responses....
DNA immunization, or the use of antigen-expressing DNAs to raise immune responses, represents a novel approach to the study and manipulation of immune responses. In this dissertation, we examine the...
Thesis (Ph. D.)--University of Massachusetts Graduate School of Biomedical Sciences, 1998.
Robinson, Harriet L., Torres, Celia Aurora Tiglao
DNA vaccines use eukaryotic expression vectors to produce immunizing proteins in the vaccinated host. Popular methods of delivery are intramuscular and intradermal saline injections of DNA and gene...
Iwasaki, Akiko, Torres, Celia Aurora Tiglao, Ohashi, Pamela S., Robinson, Harriet L., Barber, Brian H.
Although plasmid DNA immunization provides an effective means of inducing CTL responses to an expressed Ag, the mechanism by which CTL precursors are activated remains to be established. Insights...
Torres, Celia Aurora Tiglao, Iwasaki, Akiko, Barber, Brian H., Robinson, Harriet L.
Surgical ablations revealed different dependencies on the injection site tissue for i.m. needle and epidermal gene gun DNA immunizations. Excision of an injected muscle bundle within 10 min of DNA...