Ben-Shachar, Shay, Chahrour, Maria, Thaller, Christina, Shaw, Chad A., Zoghbi, Huda Y.
A group of post-natal neurodevelopmental disorders collectively referred to as MeCP2 disorders are caused by aberrations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Loss of MeCP2...
Reid, Jeffrey G., Nagaraja, Ankur K., Lynn, Francis C., Drabek, Rafal B., Muzny, Donna M., Shaw, Chad A., ...
Massively parallel sequencing of millions of
Regulatory Pathway Analysis by High-Throughput In Situ Hybridization (2007)
Axel Visel, James Carson, Judit Oldekamp, Marei Warnecke, Vladimira Jakubcakova, Xunlei Zhou, ...
Automated in situ hybridization enables the construction of comprehensive atlases of gene expression patterns in mammals. Such atlases can become Web-searchable digital expression maps of individual...
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation (2007)
Stuart M. Chambers, Chad A. Shaw, Catherine Gatza, C. Joseph Fisk, Lawrence A. Donehower, Margaret A. Goodell
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we...
Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells (2006)
Carlos A. Ramos, Teresa A. Bowman, Nathan C. Boles, Akil A. Merchant, Yayun Zheng, Irma Parra, ...
Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood...
Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells (2006)
Carlos A. Ramos, Teresa A Bowman, Nathan C Boles, Akil A Merchant, Yayun Zheng, Irma Parra, ...
Although HSC are the best studied of all adult stem cells, little is known about the mechanisms that regulate their fundamental properties, such as the decision between self-renewal and...
Yu, Wendong, Wang, Yan, Shaw, Chad A, Qin, Xiao-Feng, Rice, Andrew P
Abstract Background P-TEFb, a general RNA polymerase II elongation factor, is composed of CDK9 (cyclin-dependent kinase 9) as a catalytic unit and either cyclin T1, T2 or K as a regulatory subunit....
Peiffer, Daniel A., Le, Jennie M., Steemers, Frank J., Chang, Weihua, Jenniges, Tony, Garcia, Francisco, ...
Array-CGH is a powerful tool for the detection of chromosomal aberrations. The introduction of high-density SNP genotyping technology to genomic profiling, termed SNP-CGH, represents a further...
Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease (2006)
Lee, Jennifer A., Inoue, Ken, Cheung, Sau W., Shaw, Chad A., Stankiewicz, Pawel, Lupski, James R.
Genomic architecture, higher order structural features of the human genome, can provide molecular substrates for recurrent sub-microscopic chromosomal rearrangements, or may result in genomic...
Peiffer, Daniel A., Le, Jennie M., Steemers, Frank J., Chang, Weihua, Jenniges, Tony, Garcia, Francisco, ...
Array-CGH is a powerful tool for the detection of chromosomal aberrations. The introduction of high-density SNP genotyping technology to genomic profiling, termed SNP-CGH, represents a further...
Role of Genomic Architecture in PLP1 Duplication Causing Pelizaeus-Merzbacher Disease (2006)
Lee, Jennifer A., Inoue, Ken, Cheung, Sau W., Shaw, Chad A., Stankiewicz, Pawel, Lupski, James R.
Genomic architecture, higher order structural features of the human genome, can provide molecular substrates for recurrent submicroscopic chromosomal rearrangements, or may result in genomic...
Fariba Behbod, Wa Xian, Chad A. Shaw, Susan G. Hilsenbeck, Anna Tsimelzon, Jeffrey M. Rosen, ...
The online version of this article, along with updated information and services, is located on
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells (2004)
Teresa A. Venezia, Akil A. Merchant, Carlos A. Ramos, Nathan L. Whitehouse, Andrew S. Young, Chad A. Shaw, ...
This comprehensive study of gene expression in hematopoietic stem cells reveals some key cellular changes that occur when the stem cells transition from quiescence to proliferation and back again.
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells (2004)
Teresa A. Venezia, Akil A. Merchant, Carlos A. Ramos, Nathan L. Whitehouse, Andrew S. Young, Chad A. Shaw, ...
Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single...
Yu, Wei, Ballif, Blake C., Kashork, Catherine D., Heilstedt, Heidi A., Howard, Leslie A., Cai, Wei-Wen, ...
Chromosomal abnormalities, such as deletions and duplications, are characterized by specific and often complex phenotypes resulting from an imbalance in normal gene dosage. However, routine...
Ballif, Blake C., Yu, Wei, Shaw, Chad A., Kashork, Catherine D., Shaffer, Lisa G.
Terminal deletions of 1p36 result in a mental retardation syndrome that is presumably caused by haploinsufficiency of a number of genes. Although monosomy 1p36 is the most commonly observed terminal...
Yu, Wei, Ballif, Blake C., Kashork, Catherine D., Heilstedt, Heidi A., Howard, Leslie A., Cai, Wei-Wen, ...
Chromosomal abnormalities, such as deletions and duplications, are characterized by specific and often complex phenotypes resulting from an imbalance in normal gene dosage. However, routine...
Ballif, Blake C., Yu, Wei, Shaw, Chad A., Kashork, Catherine D., Shaffer, Lisa G.
Terminal deletions of 1p36 result in a mental retardation syndrome that is presumably caused by haploinsufficiency of a number of genes. Although monosomy 1p36 is the most commonly observed terminal...
Yu, Wei, Ballif, Blake C., Kashork, Catherine D., Heilstedt, Heidi A., Howard, Leslie A., Cai, Wei-Wen, ...
Chromosomal abnormalities, such as deletions and duplications, are characterized by specific and often complex phenotypes resulting from an imbalance in normal gene dosage. However, routine...
Ballif, Blake C., Yu, Wei, Shaw, Chad A., Kashork, Catherine D., Shaffer, Lisa G.
Terminal deletions of 1p36 result in a mental retardation syndrome that is presumably caused by haploinsufficiency of a number of genes. Although monosomy 1p36 is the most commonly observed terminal...
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
Venezia, Teresa A, Merchant, Akil A, Ramos, Carlos A, Whitehouse, Nathan L, Young, Andrew S, Shaw, Chad A, ...
Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single...
Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
Ramos, Carlos A, Bowman, Teresa A, Boles, Nathan C, Merchant, Akil A, Zheng, Yayun, Parra, Irma, ...
Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood...
Correction: Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
Ramos, Carlos A, Bowman, Teresa A, Boles, Nathan C, Merchant, Akil A, Zheng, Yayun, Parra, Irma, ...
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
Venezia, Teresa A, Merchant, Akil A, Ramos, Carlos A, Whitehouse, Nathan L, Young, Andrew S, Shaw, Chad A, ...
Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single...
Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
Ramos, Carlos A, Bowman, Teresa A, Boles, Nathan C, Merchant, Akil A, Zheng, Yayun, Parra, Irma, ...
Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood...
Correction: Evidence for Diversity in Transcriptional Profiles of Single Hematopoietic Stem Cells
Ramos, Carlos A, Bowman, Teresa A, Boles, Nathan C, Merchant, Akil A, Zheng, Yayun, Parra, Irma, ...
High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping
Peiffer, Daniel A., Le, Jennie M., Steemers, Frank J., Chang, Weihua, Jenniges, Tony, Garcia, Francisco, ...
Array-CGH is a powerful tool for the detection of chromosomal aberrations. The introduction of high-density SNP genotyping technology to genomic profiling, termed SNP-CGH, represents a further...
Clinical Implementation of Chromosomal Microarray Analysis: Summary of 2513 Postnatal Cases
Lu, Xinyan, Shaw, Chad A., Patel, Ankita, Li, Jiangzhen, Cooper, M. Lance, Wells, William R., ...
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Chambers, Stuart M, Shaw, Chad A, Gatza, Catherine, Fisk, C. Joseph, Donehower, Lawrence A, Goodell, Margaret A
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we...
Regulatory Pathway Analysis by High-Throughput In Situ Hybridization
Visel, Axel, Carson, James, Oldekamp, Judit, Warnecke, Marei, Jakubcakova, Vladimira, Zhou, Xunlei, ...
Automated in situ hybridization enables the construction of comprehensive atlases of gene expression patterns in mammals. Such atlases can become Web-searchable digital expression maps of individual...
Kustikova, Olga S., Geiger, Hartmut, Li, Zhixiong, Brugman, Martijn H., Chambers, Stuart M., Shaw, Chad A., ...
Evidence from model organisms and clinical trials reveals that the random insertion of retrovirus-based vectors in the genome of long-term repopulating hematopoietic cells may increase self-renewal...
Ben-Shachar, Shay, Ou, Zhishuo, Shaw, Chad A., Belmont, John W., Patel, Millan S., Hummel, Marybeth, ...
Microdeletions within chromosome 22q11.2 cause a variable phenotype, including DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS). About 97% of patients with DGS/VCFS have either a common...
Novel MicroRNA Candidates and miRNA-mRNA Pairs in Embryonic Stem (ES) Cells
Gu, Peili, Reid, Jeffrey G., Gao, Xiaolian, Shaw, Chad A., Creighton, Chad, Tran, Peter L., ...
Reid, Jeffrey G., Nagaraja, Ankur K., Lynn, Francis C., Drabek, Rafal B., Muzny, Donna M., Shaw, Chad A., ...
Massively parallel sequencing of millions of
Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus
Ben-Shachar, Shay, Chahrour, Maria, Thaller, Christina, Shaw, Chad A., Zoghbi, Huda Y.
A group of post-natal neurodevelopmental disorders collectively referred to as MeCP2 disorders are caused by aberrations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Loss of MeCP2...