Changchun Xiao

MicroRNA profiling of the murine hematopoietic system (2005)

Monticelli, Silvia, Ansel, K Mark, Xiao, Changchun, Socci, Nicholas D, Krichevsky, Anna M, Thai, To-Ha, ...

Abstract Background MicroRNAs (miRNAs) are a class of recently discovered noncoding RNA genes that post-transcriptionally regulate gene expression. It is becoming clear that miRNAs play an important...

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo (2005)

Shim, Jae-Hyuck, Xiao, Changchun, Paschal, Amber E., Bailey, Shannon T., Rao, Ping, Hayden, Matthew S., ...

TGF-β-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-κB and AP-1 and, therefore, plays a crucial role in...

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo (2005)

Shim, Jae-Hyuck, Xiao, Changchun, Paschal, Amber E., Bailey, Shannon T., Rao, Ping, Hayden, Matthew S., ...

TGF-β-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-κB and AP-1 and, therefore, plays a crucial role in...

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo (2005)

Shim, Jae-Hyuck, Xiao, Changchun, Paschal, Amber E., Bailey, Shannon T., Rao, Ping, Hayden, Matthew S., ...

TGF-β-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-κB and AP-1 and, therefore, plays a crucial role in...

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis (2003)

Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...

Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis (2003)

Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...

Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...

Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Kopp, Elizabeth, Medzhitov, Ruslan, Carothers, James, Xiao, Changchun, Douglas, Iris, Janeway, Charles A., ...

Activation of NF-κB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. We report the identification and characterization of a novel...

MicroRNA profiling of the murine hematopoietic system

Monticelli, Silvia, Ansel, K Mark, Xiao, Changchun, Socci, Nicholas D, Krichevsky, Anna M, Thai, To-Ha, ...

The first report of systematic miRNA profiling in cells of the hematopoietic system suggests that, in addition to regulating commitment to particular cellular lineages, miRNAs might have a general...

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Shim, Jae-Hyuck, Xiao, Changchun, Paschal, Amber E., Bailey, Shannon T., Rao, Ping, Hayden, Matthew S., ...

TGF-β-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-κB and AP-1 and, therefore, plays a crucial role in...

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

Xiao, Changchun, Shim, Jae-hyuck, Klüppel, Michael, Zhang, Samuel Shao-Min, Dong, Chen, Flavell, Richard A., ...

Bone morphogenetic proteins (Bmps) are members of the transforming growth factor β (TGFβ) superfamily that play critical roles during mouse embryogenesis. Signaling by Bmp receptors is mediated...

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Kopp, Elizabeth, Medzhitov, Ruslan, Carothers, James, Xiao, Changchun, Douglas, Iris, Janeway, Charles A., ...

Activation of NF-κB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. We report the identification and characterization of a novel...

MicroRNA profiling of the murine hematopoietic system

Monticelli, Silvia, Ansel, K Mark, Xiao, Changchun, Socci, Nicholas D, Krichevsky, Anna M, Thai, To-Ha, ...

The first report of systematic miRNA profiling in cells of the hematopoietic system suggests that, in addition to regulating commitment to particular cellular lineages, miRNAs might have a general...

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

Shim, Jae-Hyuck, Xiao, Changchun, Paschal, Amber E., Bailey, Shannon T., Rao, Ping, Hayden, Matthew S., ...

TGF-β-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-κB and AP-1 and, therefore, plays a crucial role in...

CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis

Shim, Jae-Hyuck, Xiao, Changchun, Hayden, Matthew S., Lee, Ki-Young, Trombetta, E. Sergio, Pypaert, Marc, ...

Charged MVB protein 5 (CHMP5) is a coiled coil protein homologous to the yeast Vps60/Mos10 gene and other ESCRT-III complex members, although its precise function in either yeast or mammalian cells...