Changlian Zhu

Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity (2006)

Volbracht, Christiane, Beek, Johan Van, Zhu, Changlian, Blomgren, Klas, Leist, Marcel

The pathogenesis of stroke, trauma and chronic degenerative diseases, such as Alzheimer’s disease (AD), has been linked to excitotoxic processes due to inappropriate stimulation of the...

The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin (2004)

Wang, Xiaoyang, Zhu, Changlian, Wang, Xinhua, Gerwien, Jens Gammeltoft, Schrattenholz, Andre, Sandberg, Mats, ...

Recently, erythropoietin (EPO) and the nonerythropoietic derivative asialoEPO have been linked to tissue protection in the nervous system. In this study, we tested their effects in a model of...

Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia. (2003)

Ferrand-Drake, Michel, Zhu, Changlian, Gidö, Gunilla, Hansen, Anker J, Karlsson, Jan-Olof, Bahr, Ben A, ...

Abstract is not available

Death mechanisms in status epilepticus-generated neurons and effects of additional seizures on their survival. (2003)

Ekdahl, Christine T, Zhu, Changlian, Bonde, Sara, Bahr, Ben A, Blomgren, Klas, Lindvall, Olle

Abstract is not available

Disruption of Interleukin-18, but Not Interleukin-1, Increases Vulnerability to Preterm Delivery and Fetal Mortality after Intrauterine Inflammation

Wang, Xiaoyang, Hagberg, Henrik, Mallard, Carina, Zhu, Changlian, Hedtjärn, Maj, Tiger, Carl-Fredrik, ...

Preterm birth is a major contributor of adverse perinatal outcome. Clinical data suggest that an inflammatory response is important in the process leading to preterm labor. By using a recently...

Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia

Zhu, Changlian, Wang, Xiaoyang, Deinum, Johanna, Huang, Zhiheng, Gao, Jianfeng, Modjtahedi, Nazanine, ...

Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute to the execution of cell death. Previous work...

Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain

Naylor, Andrew S., Bull, Cecilia, Nilsson, Marie K. L., Zhu, Changlian, Björk-Eriksson, Thomas, Eriksson, Peter S., ...

Cranial radiation therapy is commonly used in the treatment of childhood cancers. It is associated with cognitive impairments tentatively linked to the hippocampus, a neurogenic region of the brain...

Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury

Slemmer, Jennifer E., Zhu, Changlian, Landshamer, Stefan, Trabold, Raimund, Grohm, Julia, Ardeshiri, Ardavan, ...

Traumatic brain injury (TBI) consists of two phases: an immediate phase in which damage is caused as a direct result of the mechanical impact; and a late phase of altered biochemical events that...