Chanson J. Brumme

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells (2008)

Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, ...

BackgroundVirus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under...

CD4-Dependent Characteristics of Coreceptor Use and HIV Type 1 V3 Sequence in a Large Population of Therapy-Naive Individuals (2008)

Low, Andrew J., Marchant, David, Brumme, Chanson J., Brumme, Zabrina L., Dong, Winnie, Sing, Tobias, ...

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1 (2007)

Zabrina L. Brumme, Chanson J. Brumme, David Heckerman, Bette T. Korber, Marcus Daniels, Jonathan Carlson, ...

Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1 (2007)

Zabrina L. Brumme, Chanson J. Brumme, David Heckerman, Bette T. Korber, Marcus Daniels, Jonathan Carlson, ...

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational...

Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Brumme, Zabrina L, Brumme, Chanson J, Heckerman, David, Korber, Bette T, Daniels, Marcus, Carlson, Jonathan, ...

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational...

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Brumme, Zabrina L, Brumme, Chanson J, Heckerman, David, Korber, Bette T, Daniels, Marcus, Carlson, Jonathan, ...

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag

Carlson, Jonathan M., Brumme, Zabrina L., Rousseau, Christine M., Brumme, Chanson J., Matthews, Philippa, Kadie, Carl, ...

HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among...

Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes▿

Miura, Toshiyuki, Brockman, Mark A., Brumme, Chanson J., Brumme, Zabrina L., Carlson, Jonathan M., Pereyra, Florencia, ...

Despite reports of viral genetic defects in persons who control human immunodeficiency virus type 1 (HIV-1) in the absence of antiviral therapy, the extent to which such defects contribute to the...

Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection ▿

Brumme, Zabrina L., Brumme, Chanson J., Carlson, Jonathan, Streeck, Hendrik, John, Mina, Eichbaum, Quentin, ...

During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely...

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

Streeck, Hendrik, Brumme, Zabrina L, Anastario, Michael, Cohen, Kristin W, Jolin, Jonathan S, Meier, Angela, ...

Marcus Altfeld and colleagues suggest that the exhaustion of virus-specific CD8+ T cells during chronic HIV infection likely results from the persistence of antigen.

HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1 ▿

Miura, Toshiyuki, Brockman, Mark A., Brumme, Zabrina L., Brumme, Chanson J., Pereyra, Florencia, Trocha, Alicja, ...

Human immunodeficiency virus type 1 (HIV-1)-infected persons who maintain plasma viral loads of

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins

Brumme, Zabrina L., John, Mina, Carlson, Jonathan M., Brumme, Chanson J., Chan, Dennison, Brockman, Mark A., ...

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition▿

Miura, Toshiyuki, Brockman, Mark A., Schneidewind, Arne, Lobritz, Michael, Pereyra, Florencia, Rathod, Almas, ...

Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below the limit of commercial assay detection (

HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers▿

Miura, Toshiyuki, Brumme, Chanson J., Brockman, Mark A., Brumme, Zabrina L., Pereyra, Florencia, Block, Brian L., ...

Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are...

Transmission and Long-Term Stability of Compensated CD8 Escape Mutations▿

Schneidewind, Arne, Brumme, Zabrina L., Brumme, Chanson J., Power, Karen A., Reyor, Laura L., O'Sullivan, Kristin, ...

Human immunodeficiency virus effectively evades CD8+ T-cell responses through the development of CD8 escape mutations. Recent reports documenting reversion of transmitted mutations and the impact of...