Chantal Beekman

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells (2007)

Bracken, Adrian P., Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, ...

The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood. Here, we show...

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. (2005)

Doumont, Gilles, Martoriati, Alain, Beekman, Chantal, Bogaerts, Sven, Mee, Patrick J, Bureau, Fabrice, ...

In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new...

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

Doumont, Gilles, Martoriati, Alain, Beekman, Chantal, Bogaerts, Sven, Mee, Patrick J, Bureau, Fabrice, ...

In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new...

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

Doumont, Gilles, Martoriati, Alain, Beekman, Chantal, Bogaerts, Sven, Mee, Patrick J, Bureau, Fabrice, ...

In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new...

Evolutionarily Conserved Role of Nucleostemin: Controlling Proliferation of Stem/Progenitor Cells during Early Vertebrate Development▿ †

Beekman, Chantal, Nichane, Massimo, De Clercq, Sarah, Maetens, Marion, Floss, Thomas, Wurst, Wolfgang, ...

Nucleostemin (NS) is a putative GTPase expressed preferentially in the nucleoli of neuronal and embryonic stem cells and several cancer cell lines. Transfection and knockdown studies indicated that...

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Bracken, Adrian P., Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, ...

The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood. Here, we show...