Bridging the gap between systems biology and medicine (2009)
Clermont, Gilles, Auffray, Charles, Moreau, Yves, Rocke, David M, Dalevi, Daniel, Dubhashi, Devdatt, ...
Abstract Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful...
Computational disease modeling – fact or fiction? (2009)
Tegnér, Jesper N, Compte, Albert, Auffray, Charles, An, Gary, Cedersund, Gunnar, Clermont, Gilles, ...
Abstract Background Biomedical research is changing due to the rapid accumulation of experimental data at an unprecedented scale, revealing increasing degrees of complexity of biological processes....
Sharing knowledge: a new frontier for public-private partnerships in medicine (2009)
Abstract To help overcome the bottlenecks that limit the development of diagnostic and therapeutic products, academic and industrial researchers, patient organizations and charities, and regulatory...
Systems medicine: the future of medical genomics and healthcare (2009)
Auffray, Charles, Chen, Zhu, Hood, Leroy
Abstract High-throughput technologies for DNA sequencing and for analyses of transcriptomes, proteomes and metabolomes have provided the foundations for deciphering the structure, variation and...
In this article we continue our exploration of the historical roots of systems biology by considering the work of William Harvey. Central arguments in his work on the movement of the heart and the...
Computational disease modeling - fact or fiction? (2009)
Tegner, Jesper N, Compte, Albert, Auffray, Charles, An, Gary, Cedersund, Gunnar, Clermont, Gilles, ...
Background: Biomedical research is changing due to the rapid accumulation of experimental data at an unprecedented scale, revealing increasing degrees of complexity of biological processes. Life...
Report on EU-USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008) (2009)
Aebersold, Ruedi, Auffray, Charles, Baney, Erin, Et Al.
Molecular Oncology Vol.3 Nr.1, 9 - 17
Editorial Sharing knowledge: a new frontier for public-private partnerships in medicine (2009)
The electronic version of this article is the complete one and can be
Review Systems medicine: the future of medical genomics and healthcare (2009)
Charles Auffray, Zhu Chen, Leroy Hood
The electronic version of this article is the complete one and can be
Rebouissou, Sandra, Couchy, Gabrielle, Libbrecht, Louis, Balabaud, Charles, Imbeaud, Sandrine, Auffray, Charles, ...
BACKGROUND/AIMS: Focal nodular hyperplasias (FNHs) are benign liver lesions considered to be a hyperplastic response to increased blood flow in normal liver. In contrast, FNH-like lesions/nodules...
Rebouissou, Sandra, Couchy, Gabrielle, Libbrecht, Louis, Balabaud, Charles, Imbeaud, Sandrine, Auffray, Charles, ...
BACKGROUND/AIMS: Focal nodular hyperplasias (FNHs) are benign liver lesions considered to be a hyperplastic response to increased blood flow in normal liver. In contrast, FNH-like lesions/nodules...
Rebouissou, Sandra, Couchy, Gabrielle, Libbrecht, Louis, Balabaud, Charles, Imbeaud, Sandrine, Auffray, Charles, ...
BACKGROUND/AIMS: Focal nodular hyperplasias (FNHs) are benign liver lesions considered to be a hyperplastic response to increased blood flow in normal liver. In contrast, FNH-like lesions/nodules...
Rebouissou, Sandra, Imbeaud, Sandrine, Balabaud, Charles, Boulanger, Virginie, Bertrand-Michel, Justine, Tercé, François, ...
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1alpha (HNF1alpha) were identified in 50% of hepatocellular adenomas (HCA)...
Rebouissou, Sandra, Imbeaud, Sandrine, Balabaud, Charles, Boulanger, Virginie, Bertrand-Michel, Justine, Tercé, François, ...
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1alpha (HNF1alpha) were identified in 50% of hepatocellular adenomas (HCA)...
Rebouissou, Sandra, Imbeaud, Sandrine, Balabaud, Charles, Boulanger, Virginie, Bertrand-Michel, Justine, Tercé, François, ...
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1alpha (HNF1alpha) were identified in 50% of hepatocellular adenomas (HCA)...
Deciphering cellular states of innate tumor drug responses (2006)
Graudens, Esther, Boulanger, Virginie, Mollard, Cindy, Mariage-Samson, Régine, Barlet, Xavier, Grémy, Guilaine, ...
Abstract Background The molecular mechanisms underlying innate tumor drug resistance, a major obstacle to successful cancer therapy, remain poorly understood. In colorectal cancer (CRC), molecular...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
Abstract Aims Myeloblastosis Associated Virus type 1 (N) [MAV 1(N)] induces specifically nephroblastomas in 8–10 weeks when injected to newborn chicken. The MAV-induced nephroblastomas constitute a...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
ABSTRACT : AIMS : Myeloblastosis Associated Virus type 1 (N) [MAV 1(N)] induces specifically nephroblastomas in 8-10 weeks when injected to newborn chicken. The MAV-induced nephroblastomas constitute...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
AIMS : Myeloblastosis Associated Virus type 1 (N) [MAV 1(N)] induces specifically nephroblastomas in 8-10 weeks when injected to newborn chicken. The MAV-induced nephroblastomas constitute a unique...
Guillemot, Fabrice, Cerutti, Italina, Auffray, Charles, Devignes, Marie-Dominique
Brain-derived neurotrophic factor (BDNF) is an attractive component for the treatment of various neurodegenerative diseases such as Alzheimer's or Parkinson's disease. Innovative non invasive...
Guillemot, Fabrice, Cerutti, Italina, Auffray, Charles, Devignes, Marie-Dominique
Brain-derived neurotrophic factor (BDNF) is an attractive component for the treatment of various neurodegenerative diseases such as Alzheimer's or Parkinson's disease. Innovative non invasive...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
AIMS : Myeloblastosis Associated Virus type 1 (N) [MAV 1(N)] induces specifically nephroblastomas in 8-10 weeks when injected to newborn chicken. The MAV-induced nephroblastomas constitute a unique...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
AIMS : Myeloblastosis Associated Virus type 1 (N) [MAV 1(N)] induces specifically nephroblastomas in 8-10 weeks when injected to newborn chicken. The MAV-induced nephroblastomas constitute a unique...
Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...
The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...
Imbeaud, Sandrine, Graudens, Esther, Boulanger, Virginie, Barlet, Xavier, Zaborski, Patrick, Eveno, Eric, ...
While it is universally accepted that intact RNA constitutes the best representation of the steady-state of transcription, there is no gold standard to define RNA quality prior to gene expression...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
The Human Anatomic Gene Expression Library (2004)
Motohiko Tanino, Marie-anne Debily, Takuro Tamura, Teruyoshi Hishiki, Osamu Ogasawara, Katsuji Murakawa, ...
(H-ANGEL), the H-Inv integrative display of human gene expression across disparate
Transcriptome Analysis of Two Bovine Muscles during Ontogenesis (2003)
Sudre, Karine, Leroux, Christine, Piétu, Geneviève, Cassar-Malek, Isabelle, Petit, Elisabeth, Listrat, Anne, ...
Macro-arrays, on which 1339 human skeletal muscle cDNA clone inserts had been spotted as PCR products, were used to make large-scale measurement of gene expression in bovine muscles during...
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays (2002)
Decraene, Charles, Brugg, Bernard, Ruberg, Merle, Eveno, Eric, Matingou, Christiane, Tahi, Fariza, ...
Abstract Background Ceramide is important in many cell responses, such as proliferation, differentiation, growth arrest and apoptosis. Elevated ceramide levels have been shown to induce apoptosis in...
Fayein, Nicole-Adeline, Stankoff, Bernard, Auffray, Charles, Devignes, Marie-Dominique
Macro-array differential hybridization of a collection of 5058 human gene transcripts represented in an IMAGE infant brain cDNA library has led to the identification of transcripts displaying...
Chelala, Claude, Devignes, Marie-Dominique, Imbeaud, Sandrine, Zoorob, Rima, Cox, David, Auffray, Charles, ...
The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only...
Fayein, Nicole-Adeline, Stankoff, Bernard, Auffray, Charles, Devignes, Marie-Dominique
Macro-array differential hybridization of a collection of 5058 human gene transcripts represented in an IMAGE infant brain cDNA library has led to the identification of transcripts displaying...
Chelala, Claude, Devignes, Marie-Dominique, Imbeaud, Sandrine, Zoorob, Rima, Cox, David, Auffray, Charles, ...
The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only...
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. (2002)
Decraene, Charles, Brugg, Bernard, Ruberg, Merle, Eveno, Eric, Matingou, Christiane, Tahi, Fariza, ...
BACKGROUND: Ceramide is important in many cell responses, such as proliferation, differentiation, growth arrest and apoptosis. Elevated ceramide levels have been shown to induce apoptosis in primary...
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. (2002)
Decraene, Charles, Brugg, Bernard, Ruberg, Merle, Eveno, Eric, Matingou, Christiane, Tahi, Fariza, ...
BACKGROUND: Ceramide is important in many cell responses, such as proliferation, differentiation, growth arrest and apoptosis. Elevated ceramide levels have been shown to induce apoptosis in primary...
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. (2002)
Decraene, Charles, Brugg, Bernard, Ruberg, Merle, Eveno, Eric, Matingou, Christiane, Tahi, Fariza, ...
BACKGROUND: Ceramide is important in many cell responses, such as proliferation, differentiation, growth arrest and apoptosis. Elevated ceramide levels have been shown to induce apoptosis in primary...
Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1 (2001)
Chelala, Claude, Imbeaud, Sandrine, Devignes, Marie-Dominique, Zoorob, Rima, Auffray, Charles
In this report, we describe a refinement of the human transcript map of chromosome 1p13.1, a subregion undergoing many aberrations in various types of human cancers. Publicly available genetic...
Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1 (2001)
Chelala, Claude, Imbeaud, Sandrine, Devignes, Marie-Dominique, Zoorob, Rima, Auffray, Charles
In this report, we describe a refinement of the human transcript map of chromosome 1p13.1, a subregion undergoing many aberrations in various types of human cancers. Publicly available genetic...
Piétu, Geneviève, Mariage-Samson, Régine, Fayein, Nicole-Adeline, Matingou, Christiane, Eveno, Eric, Houlgatte, Rémi, ...
Piétu, Geneviève, Eveno, Eric, Soury-Segurens, Béatrice, Fayein, Nicole-Adeline, Mariage-Samson, Régine, Matingou, Christiane, ...
A radiation hybrid map of the human genome (1996)
Gabor Gyapay, Karin Schmitt, Cécile Fizames, Hywel Jones, Nathalie Vega-czarny, Dominique Spillett, ...
We have developed a panel of whole-genome radiation hybrids by fusing irradiated diploid human fibroblasts with recipient hamster cells. This panel of 168 cell lines has been typed with...
Martin, Annick, Toselli, Esther, Rosier, Marie-Françoise, Auffray, Charles, Devignes, Marie-Dominique
Chiannilkulchal, Nuchanard, Pasturaud, Patricia, Richard, Isabelle, Auffray, Charles, Beckmann, Jacques S.
Previous genetic and physical studies of LGMD2A, an autosomal recessive form of limb-girdle muscular dystrophy, have led to the establishment of a 10–12 Mb YAC contig encompassing the morbid locus....
Autiero, Monica, Houlgatte, Rémi, Martin, Michelle, Auffray, Charles, Guardiola, John, Piatier-Tonneau, Dominique, ...
HLA class II molecules and the HIV envelope glycoprotein gp120 are ligands of CD4. Reciprocal interaction sites have been well characterized for gp120 and CD4, but require further definition for HLA...
Characterization of avian natural killer cells and their intracellular CD3 protein complex (1994)
Göbel, Thomas W. F., Chen, Chen-Lo H., Shrimpf, Jane, Grossi, Carlo E., Bernot, Alain, Bucy, R. Pat, ...
Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the...
Mouse heavy chain variable regions: nucleotide sequence of a germ-line VH gene segment (1981)
Ollo, Roger, Auffray, Charles, Sikorav, Jean-Louis, Rougeon, François
We have constructed a library of Balb/c mouse embryo DNA in the vector Charon 4A. The library was searched for sequences homologous to the VH region of a cloned cDNA of the UPC10 heavy chain mRNA. In...
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays
Decraene, Charles, Brugg, Bernard, Ruberg, Merle, Eveno, Eric, Matingou, Christiane, Tahi, Fariza, ...
A cell-culture model was used to establish a profile of gene expression during the effector phase of ceramide-mediated cell death. Of the 239 genes that met the criteria for differential...
Piétu, Geneviève, Mariage-Samson, Régine, Fayein, Nicole-Adeline, Matingou, Christiane, Eveno, Eric, Houlgatte, Rémi, ...
Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative...
Piétu, Geneviève, Eveno, Eric, Soury-Segurens, Béatrice, Fayein, Nicole-Adeline, Mariage-Samson, Régine, Matingou, Christiane, ...
Sequence, gene mapping, and expression data corresponding to 910 genes transcribed in human skeletal muscle have been integrated to form the muscle module of the Genexpress IMAGE Knowledge Base....
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...
The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...
Imbeaud, Sandrine, Graudens, Esther, Boulanger, Virginie, Barlet, Xavier, Zaborski, Patrick, Eveno, Eric, ...
While it is universally accepted that intact RNA constitutes the best representation of the steady-state of transcription, there is no gold standard to define RNA quality prior to gene expression...
Zheng, Pei-Zheng, Wang, Kan-Kan, Zhang, Qun-Ye, Huang, Qiu-Hua, Du, Yan-Zhi, Zhang, Qing-Hua, ...
Understanding the complexity and dynamics of cancer cells in response to effective therapy requires hypothesis-driven, quantitative, and high-throughput measurement of genes and proteins at both...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
Deciphering cellular states of innate tumor drug responses
Graudens, Esther, Boulanger, Virginie, Mollard, Cindy, Mariage-Samson, Régine, Barlet, Xavier, Grémy, Guilaine, ...
Transcriptional profiling of colorectal cancer samples collected before chemotherapy provides cellular signatures that differentiate subsequently diagnosed chemosensitive and resistant patients.
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays
Decraene, Charles, Brugg, Bernard, Ruberg, Merle, Eveno, Eric, Matingou, Christiane, Tahi, Fariza, ...
A cell-culture model was used to establish a profile of gene expression during the effector phase of ceramide-mediated cell death. Of the 239 genes that met the criteria for differential...
Piétu, Geneviève, Mariage-Samson, Régine, Fayein, Nicole-Adeline, Matingou, Christiane, Eveno, Eric, Houlgatte, Rémi, ...
Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative...
Piétu, Geneviève, Eveno, Eric, Soury-Segurens, Béatrice, Fayein, Nicole-Adeline, Mariage-Samson, Régine, Matingou, Christiane, ...
Sequence, gene mapping, and expression data corresponding to 910 genes transcribed in human skeletal muscle have been integrated to form the muscle module of the Genexpress IMAGE Knowledge Base....
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Tanino, Motohiko, Debily, Marie-Anne, Tamura, Takuro, Hishiki, Teruyoshi, Ogasawara, Osamu, Murakawa, Katsuji, ...
The Human Anatomic Gene Expression Library (H-ANGEL) is a resource for information concerning the anatomical distribution and expression of human gene transcripts. The tool contains protein...
Imbeaud, Sandrine, Graudens, Esther, Boulanger, Virginie, Barlet, Xavier, Zaborski, Patrick, Eveno, Eric, ...
While it is universally accepted that intact RNA constitutes the best representation of the steady-state of transcription, there is no gold standard to define RNA quality prior to gene expression...
Zheng, Pei-Zheng, Wang, Kan-Kan, Zhang, Qun-Ye, Huang, Qiu-Hua, Du, Yan-Zhi, Zhang, Qing-Hua, ...
Understanding the complexity and dynamics of cancer cells in response to effective therapy requires hypothesis-driven, quantitative, and high-throughput measurement of genes and proteins at both...
Li, Chang Long, Coullin, Philippe, Bernheim, Alain, Joliot, Véronique, Auffray, Charles, Zoroob, Rima, ...
Deciphering cellular states of innate tumor drug responses
Graudens, Esther, Boulanger, Virginie, Mollard, Cindy, Mariage-Samson, Régine, Barlet, Xavier, Grémy, Guilaine, ...
Transcriptional profiling of colorectal cancer samples collected before chemotherapy provides cellular signatures that differentiate subsequently diagnosed chemosensitive and resistant patients.
Pomiès, Pascal, Pashmforoush, Mohammad, Vegezzi, Cristina, Chien, Kenneth R., Auffray, Charles, Beckerle, Mary C.
In this report, an antisense RNA strategy has allowed us to show that disruption of ALP expression affects the expression of the muscle transcription factors myogenin and MyoD, resulting in the...
A Functional and Regulatory Network Associated with PIP Expression in Human Breast Cancer
Debily, Marie-Anne, Marhomy, Sandrine El, Boulanger, Virginie, Eveno, Eric, Mariage-Samson, Régine, Camarca, Alessandra, ...
Systems medicine: the future of medical genomics and healthcare
Auffray, Charles, Chen, Zhu, Hood, Leroy
High-throughput technologies for DNA sequencing and for analyses of transcriptomes, proteomes and metabolomes have provided the foundations for deciphering the structure, variation and function of...
Sharing knowledge: a new frontier for public-private partnerships in medicine
To help overcome the bottlenecks that limit the development of diagnostic and therapeutic products, academic and industrial researchers, patient organizations and charities, and regulatory and...
Auffray, Charles, Noble, Denis
In this article we continue our exploration of the historical roots of systems biology by considering the work of William Harvey. Central arguments in his work on the movement of the heart and the...
Computational disease modeling – fact or fiction?
Tegnér, Jesper N, Compte, Albert, Auffray, Charles, An, Gary, Cedersund, Gunnar, Clermont, Gilles, ...
Bridging the gap between systems biology and medicine
Clermont, Gilles, Auffray, Charles, Moreau, Yves, Rocke, David M, Dalevi, Daniel, Dubhashi, Devdatt, ...
Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are...