Darwin and Huxley revisited: the origin of allometry (2009)
Abstract The relative sizes of parts of an organism frequently depend on the absolute size of the individual, a relationship that is generally described by power laws. I show here that these power...
Novel Integrate-and-re-like Model of Repetitive Firing in Cortical Neurons (2007)
Charles Stevens The, Charles F. Stevens, Anthony M. Zador
Cortical neurons convert synaptic inputs arising from thousands of other neurons into a single output spike train. In order to better understand this basic computation, wehave derived a simple...
Vitaly A. Klyachko, Charles F. Stevens
Excitatory and inhibitory hippocampal synapses express complementary short term plasticity components that cooperate to amplify excitatory transmission in response to naturalistic stimulation.
Vitaly A. Klyachko, Charles F. Stevens
Short-term synaptic plasticity (STP) is an important mechanism for modifying neural circuits during computation. Although STP is much studied, its role in the processing of complex natural spike...
Resettable Apparatus for Use with Trigger Mechanism (1998)
Vendetti, Vincent J., Canaday, Michael J., Stevens, Charles F.
A resettable trigger mechanism has an activating rod with a first portion slidably mounted in a housing and a second portion extending from the housing. The activating rod has a notch formed in its...
Information through a Spiking Neuron (1996)
Charles F. Stevens, Anthony Zador
While it is generally agreed that neurons transmit information about their synaptic inputs through spike trains, the code by which this information is transmitted is not well understood. An upper...
Ion permeation through membrane channels / edited Charles F. Stevens, Richard W. Tsien (1979)
Stevens, Charles F, Tsien, Richard W
Incluye bibliografía e índice
Seamans, Jeremy K., Durstewitz, Daniel, Christie, Brian R., Stevens, Charles F., Sejnowski, Terrence J.
Dopamine acts mainly through the D1/D5 receptor in the prefrontal cortex (PFC) to modulate neural activity and behaviors associated with working memory. To understand the mechanism of this effect, we...
Murthy, Venkatesh N., Sejnowski, Terrence J., Stevens, Charles F.
Synaptic N-methyl-d-aspartate (NMDA) receptors detect coincident pre- and postsynaptic activity and play a critical role in triggering changes in synaptic strength at central synapses. Despite...
Nonsaturation of AMPA and NMDA receptors at hippocampal synapses
McAllister, A. Kimberley, Stevens, Charles F.
An important issue in synaptic physiology is the extent to which postsynaptic receptors are saturated by the neurotransmitter released from a single synaptic vesicle. Although the bulk of evidence...
Readily releasable pool size changes associated with long term depression
Goda, Yukiko, Stevens, Charles F.
We have estimated, for hippocampal neurons in culture, the size of the autaptic readily releasable pool before and after stimulation of the sort that produces culture long term depression (LTD). This...
“Kiss and run” exocytosis at hippocampal synapses
Stevens, Charles F., Williams, James H.
We have combined electrophysiology and imaging to measure the release of neurotransmitter and fluorescent dye at synapses of cultured hippocampal neurons. These experiments have revealed a “kiss...
Very short-term plasticity in hippocampal synapses
Dobrunz, Lynn E., Huang, Emily P., Stevens, Charles F.
Hippocampal pyramidal neurons often fire in bursts of action potentials with short interspike intervals (2–10 msec). These high-frequency bursts may play a critical role in the functional behavior...
Connectivity optimization and the positioning of cortical areas
Klyachko, Vitaly A., Stevens, Charles F.
By examining many alternative arrangements of cortical areas, we have found that the arrangement actually present in the brain minimizes the volume of the axons required for interconnecting the...
Topographic specificity of functional connections from hippocampal CA3 to CA1
Brivanlou, Iman H., Dantzker, Jami L. M., Stevens, Charles F., Callaway, Edward M.
The hippocampus is a cortical region thought to play an important role in learning and memory. Most of our knowledge about the detailed organization of hippocampal circuitry responsible for these...
Preserving properties of object shape by computations in primary visual cortex
Although our visual system is extremely good at extracting objects from the visual scene, this process involves complicated computations that are thought to require image processing by many...
Klyachko, Vitaly A, Stevens, Charles F
Short-term synaptic plasticity (STP) is an important mechanism for modifying neural circuits during computation. Although STP is much studied, its role in the processing of complex natural spike...
Inferences about Membrane Properties from Electrical Noise Measurements
Four sources of electrical noise in biological membranes, each with a different physical basis, are discussed; the analysis of each type of noise potentially yields a different sort of information...
Seamans, Jeremy K., Durstewitz, Daniel, Christie, Brian R., Stevens, Charles F., Sejnowski, Terrence J.
Dopamine acts mainly through the D1/D5 receptor in the prefrontal cortex (PFC) to modulate neural activity and behaviors associated with working memory. To understand the mechanism of this effect, we...
Murthy, Venkatesh N., Sejnowski, Terrence J., Stevens, Charles F.
Synaptic N-methyl-d-aspartate (NMDA) receptors detect coincident pre- and postsynaptic activity and play a critical role in triggering changes in synaptic strength at central synapses. Despite...
Nonsaturation of AMPA and NMDA receptors at hippocampal synapses
McAllister, A. Kimberley, Stevens, Charles F.
An important issue in synaptic physiology is the extent to which postsynaptic receptors are saturated by the neurotransmitter released from a single synaptic vesicle. Although the bulk of evidence...
Readily releasable pool size changes associated with long term depression
Goda, Yukiko, Stevens, Charles F.
We have estimated, for hippocampal neurons in culture, the size of the autaptic readily releasable pool before and after stimulation of the sort that produces culture long term depression (LTD). This...
“Kiss and run” exocytosis at hippocampal synapses
Stevens, Charles F., Williams, James H.
We have combined electrophysiology and imaging to measure the release of neurotransmitter and fluorescent dye at synapses of cultured hippocampal neurons. These experiments have revealed a “kiss...
Very short-term plasticity in hippocampal synapses
Dobrunz, Lynn E., Huang, Emily P., Stevens, Charles F.
Hippocampal pyramidal neurons often fire in bursts of action potentials with short interspike intervals (2–10 msec). These high-frequency bursts may play a critical role in the functional behavior...
Connectivity optimization and the positioning of cortical areas
Klyachko, Vitaly A., Stevens, Charles F.
By examining many alternative arrangements of cortical areas, we have found that the arrangement actually present in the brain minimizes the volume of the axons required for interconnecting the...
Topographic specificity of functional connections from hippocampal CA3 to CA1
Brivanlou, Iman H., Dantzker, Jami L. M., Stevens, Charles F., Callaway, Edward M.
The hippocampus is a cortical region thought to play an important role in learning and memory. Most of our knowledge about the detailed organization of hippocampal circuitry responsible for these...
Preserving properties of object shape by computations in primary visual cortex
Although our visual system is extremely good at extracting objects from the visual scene, this process involves complicated computations that are thought to require image processing by many...
Klyachko, Vitaly A, Stevens, Charles F
Short-term synaptic plasticity (STP) is an important mechanism for modifying neural circuits during computation. Although STP is much studied, its role in the processing of complex natural spike...
Inferences about Membrane Properties from Electrical Noise Measurements
Four sources of electrical noise in biological membranes, each with a different physical basis, are discussed; the analysis of each type of noise potentially yields a different sort of information...
General design principle for scalable neural circuits in a vertebrate retina
Lee, Sunhwa, Stevens, Charles F.
Unlike mammals, fish continue to grow throughout their lives, to increase the size of their eyes and brain, and to add new neurons to both. As a result of visual system growth, the ability to detect...
Probing synaptic vesicle fusion by altering mechanical properties of the neuronal surface membrane
Zhu, Yongling, Stevens, Charles F.
Because synaptic vesicle exocytosis is a nano-mechanical process, it should be influenced by the mechanical properties of the cell membrane to which the vesicle fuses. By dissolving surfactants at...
Darwin and Huxley revisited: the origin of allometry
The relative sizes of parts of an organism frequently depend on the absolute size of the individual, a relationship that is generally described by power laws. I show here that these power laws are a...
Predictable irregularities in retinal receptive fields
Liu, Yuan Sophie, Stevens, Charles F., Sharpee, Tatyana O.
Understanding how the nervous system achieves reliable performance using unreliable components is important for many disciplines of science and engineering, in part because it can suggest ways to...