Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...
Previous experiments using enzyme inhibitors, cell lysates, and purified enzyme have suggested that puromycin-sensitive aminopeptidase (PSA) plays a role in creating and destroying MHC class...
Towne, Charles Fenton, York, Ian A., Watkins, Levi B., Lazo, John S., Rock, Kenneth L.
Long oligopeptides (>10 residues) are generated during the catabolism of cellular proteins in the cytosol. To be presented to T cells, such peptides must be trimmed by aminopeptidases to the proper...
Towne, Charles Fenton, York, Ian A., Watkins, Levi B., Lazo, John S., Rock, Kenneth L.
Long oligopeptides (>10 residues) are generated during the catabolism of cellular proteins in the cytosol. To be presented to T cells, such peptides must be trimmed by aminopeptidases to the...
York, Ian A., Brehm, Michael A., Zendzian, Sophia, Towne, Charles Fenton, Rock, Kenneth L.
CD8(+) T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually...
To detect viral infections and tumors, CD8 T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are...
Thesis (Ph. D.)--University of Massachusetts Graduate School of Biomedical Sciences, 2006.
Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...
To detect viral infections and tumors, CD8+ T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are...