Karlsson, Jenny, Pütsep, Katrin, Chu, Hiutung, Kays, Robert J, Bevins, Charles L, Andersson, Mats
Abstract Background Enteric antimicrobial peptides secreted from Paneth cells, including α-defensins (in mice named cryptdins), are key effector molecules of innate immunity in the small intestine....
George, Michael D, Wehkamp, Jan, Kays, Robert J, Leutenegger, Christian M, Sabir, Sadiah, Grishina, Irina, ...
Abstract Background The small intestinal epithelium mediates vital functions of nutrient absorption and host defense. The spatial organization of the epithelial cells along the crypt-villus axis...
Reduced Paneth cell alpha-defensins in ileal Crohn's disease (2005)
Wehkamp, J, Salzman, N H, Porter, E, Nuding, S, Weichenthal, M, Petras, R E, ...
The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically...
Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract (2005)
Shen, B, Porter, E M, Reynoso, E, Shen, C, Ghosh, D, Connor, J T, ...
Background: Upper gastrointestinal tract intestinal metaplasia (IM) is termed Barrett's oesophagus (BO) or gastric intestinal metaplasia (GIM), depending on its location. BO and GIM are associated...
Molecular Cloning and Characterization of Rat Genes Encoding Homologues of Human β-Defensins
Jia, Hong Peng, Mills, Jesse N., Barahmand-Pour, Fariba, Nishimura, Darryl, Mallampali, Rama K., Wang, Guoshun, ...
β-Defensins are cationic peptides with broad-spectrum antimicrobial activity that may play a role in mucosal defenses of several organs. They have been isolated in several species, and in humans,...
Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells
Diamond, Gill, Kaiser, Vicki, Rhodes, Janice, Russell, John P., Bevins, Charles L.
Innate immunity provides an ever-present or rapidly inducible initial defense against microbial infection. Among the effector molecules of this defense in many species are broad-spectrum...
Tarver, Alan P., Clark, Douglas P., Diamond, Gill, Russell, John P., Erdjument-Bromage, Hediye, Tempst, Paul, ...
A growing body of evidence suggests that endogenous antibiotics contribute to the innate defense of mammalian mucosal surfaces. In the cow, β-defensins constitute a large family of antibiotic...
Tarver, Alan P., Clark, Douglas P., Diamond, Gill, Russell, John P., Erdjument-Bromage, Hediye, Tempst, Paul, ...
Paneth Cells and Antibacterial Host Defense in Neonatal Small Intestine
Sherman, Michael P., Bennett, Stephen H., Hwang, Freda F. Y., Sherman, Jan, Bevins, Charles L.
Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during...
Reduced Paneth cell α-defensins in ileal Crohn's disease
Wehkamp, Jan, Salzman, Nita H., Porter, Edith, Nuding, Sabine, Weichenthal, Michael, Petras, Robert E., ...
The pathogenesis of Crohn′s disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in...
Molecular Cloning and Characterization of Rat Genes Encoding Homologues of Human β-Defensins
Jia, Hong Peng, Mills, Jesse N., Barahmand-Pour, Fariba, Nishimura, Darryl, Mallampali, Rama K., Wang, Guoshun, ...
β-Defensins are cationic peptides with broad-spectrum antimicrobial activity that may play a role in mucosal defenses of several organs. They have been isolated in several species, and in humans,...
Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells
Diamond, Gill, Kaiser, Vicki, Rhodes, Janice, Russell, John P., Bevins, Charles L.
Innate immunity provides an ever-present or rapidly inducible initial defense against microbial infection. Among the effector molecules of this defense in many species are broad-spectrum...
Tarver, Alan P., Clark, Douglas P., Diamond, Gill, Russell, John P., Erdjument-Bromage, Hediye, Tempst, Paul, ...
A growing body of evidence suggests that endogenous antibiotics contribute to the innate defense of mammalian mucosal surfaces. In the cow, β-defensins constitute a large family of antibiotic...
Tarver, Alan P., Clark, Douglas P., Diamond, Gill, Russell, John P., Erdjument-Bromage, Hediye, Tempst, Paul, ...
Paneth Cells and Antibacterial Host Defense in Neonatal Small Intestine
Sherman, Michael P., Bennett, Stephen H., Hwang, Freda F. Y., Sherman, Jan, Bevins, Charles L.
Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during...
Reduced Paneth cell α-defensins in ileal Crohn's disease
Wehkamp, Jan, Salzman, Nita H., Porter, Edith, Nuding, Sabine, Weichenthal, Michael, Petras, Robert E., ...
The pathogenesis of Crohn′s disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in...
Fellermann, Klaus, Stange, Daniel E., Schaeffeler, Elke, Schmalzl, Hartmut, Wehkamp, Jan, Bevins, Charles L., ...
Defensins are endogenous antimicrobial peptides that protect the intestinal mucosa against bacterial invasion. It has been suggested that deficient defensin expression may underlie the chronic...
Godfrey, Maurice, Raghunath, Michael, Cisler, Jason, Bevins, Charles L., DePaepe, Anne, Di Rocco, Maja, ...
The Marfan syndrome (MFS) is a connective tissue disorder manifested by variable and pleiotropic features in the skeletal, ocular, and cardiovascular systems. The average life span in MFS is about 35...
Raffatellu, Manuela, Santos, Renato L., Chessa, Daniela, Wilson, R. Paul, Winter, Sebastian E., Rossetti, Carlos A., ...
The viaB locus contains genes for the biosynthesis and export of the Vi capsular antigen of Salmonella enterica serotype Typhi. Wild-type serotype Typhi induces less CXC chemokine production in...
George, Michael D, Wehkamp, Jan, Kays, Robert J, Leutenegger, Christian M, Sabir, Sadiah, Grishina, Irina, ...
Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract
Karlsson, Jenny, Pütsep, Katrin, Chu, Hiutung, Kays, Robert J, Bevins, Charles L, Andersson, Mats
Koslowski, Maureen J., Kübler, Irmgard, Chamaillard, Mathias, Schaeffeler, Elke, Reinisch, Walter, Wang, Guoxing, ...
Reduced expression of Paneth cell antimicrobial α-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway...
Regulation of C-type Lectin Antimicrobial Activity by a Flexible N-terminal Prosegment*S⃞
Mukherjee, Sohini, Partch, Carrie L., Lehotzky, Rebecca E., Whitham, Cecilia V., Chu, Hiutung, Bevins, Charles L., ...
Members of the RegIII family of intestinal C-type lectins are directly antibacterial proteins that play a vital role in maintaining host-bacterial homeostasis in the mammalian gut, yet little is...
Godinez, Ivan, Raffatellu, Manuela, Chu, Hiutung, Paixão, Tatiane A., Haneda, Takeshi, Santos, Renato L., ...
Salmonella enterica serotype Typhimurium causes an acute inflammatory reaction in the ceca of streptomycin-pretreated mice that involves T-cell-dependent induction of gamma interferon (IFN-γ),...
Winter, Sebastian E., Thiennimitr, Parameth, Nuccio, Sean-Paul, Haneda, Takeshi, Winter, Maria G., Wilson, R. Paul, ...
Salmonella enterica serotype Typhimurium causes acute inflammatory diarrhea in humans. Flagella contribute to intestinal inflammation, but the mechanism remains unclear since most mutations...