Charles M. Lapière

Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents (2007)

Mineur, Pierre, Colige, Alain, Deroanne, Christophe, Dubail, Johanne, Kesteloot, Frédéric, Habraken, Yvette, ...

Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1-4 and 8 in many cultured cells. Although not...

ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice (2007)

Kesteloot, Frédéric, Desmoulière, Alexis, Leclercq, Isabelle, Thiry, Marc, Arrese Estrada, Jorge, Prockop, Darwin J, ...

ADAMTS2 belongs to the "ADAM metallopeptidase with thrombospondin type I motif" (ADAMTS) family. Its primary function is to process collagen type I, II, III, and V precursors into mature molecules by...

Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V (2005)

Colige, Alain, Ruggiero, Florence, Vandenberghe, Isabel, Dubail, Johanne, Kesteloot, Frédéric, Van Beeumen, Jozef, ...

Processing of fibrillar collagens is required to generate collagen monomers able to self-assemble into elongated and cylindrical collagen fibrils. ADAMTS-2 belongs to the "A disintegrin and...

Effect of ADAMTS-2, a metalloproteinase containing a disintegrin domain and thrombospondin type I repeats, during angiogenesis in vitro and in vivo (2004)

Dubail, Johanne, Kesteloot, Frédéric, Motte, Patrick, Lambert, Vincent, Rakic, Jean-Marie, Lapière, Charles M, ...

15th Endothelial Cell Research Symposium

Evaluation of the function of ADAMTS-2, a metalloproteinase containing a disintegrin domain and thrombospondin type I repeats, during angiogenesis in vitro and in vivo (2004)

Kesteloot, Frédéric, Lapière, Charles M, Colige, Alain, Nusgens, Betty

Belgian Association for Cancer Research - Annual Meeting 2004

TIMP-2 and PAI-1 mRNA levels are lower in aneurysmal as compared to athero-occlusive abdominal aortas (2003)

Defawe, Olivier D, Colige, Alain, Lambert, Charles A, Munaut, Carine, Delvenne, Philippe, Lapière, Charles M, ...

Objective: Significant alterations of the vascular wall occurs in abdominal aortic aneurysm (AAA) and atherosclerotic occlusive disease (AOD) that ultimately may lead to either vascular rupture or...

In vitro stimulation of human gingival epithelial cell attachment to dentin by surface conditioning. (1999)

Van Heusden, Alain, Goffinet, Gerhard, Zahedi, Sharham, Nusgens, Betty, Lapière, Charles M., Rompen, Eric

BACKGROUND: Chemical root conditioning is widely used to improve the outcome of regenerative periodontal therapies by favoring the attachment of the regenerated periodontal structures. Although the...

In vitro modulation of human gingival epithelial cell attachment and migration by minocycline-HCL. (1998)

Van Heusden, Alain, Nusgens, Betty, Goffinet, Gerhard, Zahedi, Sharham, Lapière, Charles M., Rompen, Eric

Although the influence of tetracyclines on periodontal connective tissue cells has been the topic of many in vitro and in vivo studies, data regarding their effects on gingival epithelial cells are...

cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components

Colige, Alain, Li, Shi-Wu, Sieron, Aleksander L., Nusgens, Betty V., Prockop, Darwin J., Lapière, Charles M.

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and...

Calf Tendon Procollagen Peptidase: Its Purification and Endopeptidase Mode of Action

Kohn, Leonard D., Isersky, Chaviva, Zupnik, James, Lenaers, Albert, Lee, George, Lapière, Charles M.

The procollagen peptidase activity of calf tendon has been purified. The enzyme has a high degree of specificity for native procollagen and converts both pro α1 and α2, to α1 and α2,...

Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen

Lapière, Charles M., Lenaers, Albert, Kohn, Leonard D.

A heritable connective tissue disorder of cattle, dermatosparaxis, is characterized by an extreme fragility of the skin and the presence of additional peptides at the N-terminal extremities of the...

cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components

Colige, Alain, Li, Shi-Wu, Sieron, Aleksander L., Nusgens, Betty V., Prockop, Darwin J., Lapière, Charles M.

Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and...

Calf Tendon Procollagen Peptidase: Its Purification and Endopeptidase Mode of Action

Kohn, Leonard D., Isersky, Chaviva, Zupnik, James, Lenaers, Albert, Lee, George, Lapière, Charles M.

The procollagen peptidase activity of calf tendon has been purified. The enzyme has a high degree of specificity for native procollagen and converts both pro α1 and α2, to α1 and α2,...

Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen

Lapière, Charles M., Lenaers, Albert, Kohn, Leonard D.

A heritable connective tissue disorder of cattle, dermatosparaxis, is characterized by an extreme fragility of the skin and the presence of additional peptides at the N-terminal extremities of the...

Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents

Mineur, Pierre, Colige, Alain C., Deroanne, Christophe. F., Dubail, Johanne, Kesteloot, Frédéric, Habraken, Yvette, ...

Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1–4 and 8 in many cultured cells. Although not...