Charles R. Brown

Effect of Hairy Nightshade (Solanum Sarrachoides) Presence on Potato Nematodes, Diseases, and Insect Pests (2008)

Rick A. Boydston, Hassan Mojtahedi, Jim M. Crosslin, Charles R. Brown, Treva Anderson

Hairy nightshade is a common weed in potato rotations in the western United States. As a close relative of potato, hairy nightshade can host numerous potato nematodes, diseases, and insect pests....

DOES INTERCOLONY COMPETITION FOR FOOD AFFECT COLONY CHOICE IN CLIFF SWALLOWS? (2002)

Charles R. Brown, Mary Bomberger Brown

Explaining why breeding colonies vary in size has been a persistent problem in the study of animal spatial distribution. One hypothesis is that colony size reflects local food availability, which may...

Mosquito Abundance is Correlated with Cliff Swallow (Petrochelidon pyrrhonota) Colony Size (2002)

Charles R. Brown, Rajni A. Sethi

We measured the abundance of mosquitoes [primarily Aedes vexans (Meigen) and Culex tarsalis Coquillett] at cliff swallow (Petrochelidon pyrrhonota Vieillot) colonies of different sizes in...

EGG HATCHABILITY INCREASES WITH COLONY SIZE IN CLIFF SWALLOWS (2001)

Charles R. Brown, Mary Bomberger Brown

The percentage of otherwise successful nests containing ≥ 1 unhatched egg in Cliff Swallows (Petrochelidon pyrrhonota) varied inversely with colony size in southwestern Nebraska. Colony-site...

EVALUATION OF SELECTION ON CLIFF SWALLOWS (2000)

Trevor D. Price, Charles R. Brown, Mary Bomberger Brown

Estimates of the intensity of selection based on measurements of the living and the dead require knowledge of the fraction of the original population dying. We apply recently developed methods...

A QUASI-RANDOM SEQUENCE FOR MEMORY EXPERIMENTS (1998)

NICKERSON,RAYMOND S., BROWN,CHARLES R.

A method is presented for constructing sequences with properties which make them useful in ordering stimuli for recognition memory experiments. A main feature of the method is the facility for...

TED:A TAPE EDITOR (1998)

BROWN,CHARLES R., CONNOLLY,DOANLD W.

The principle and operation of utility program for the PDP-1 computer are described. The program is an aid in the editing of alphanumeric text in that the operator may communicate with the computer...

Birds of the Cedar Point Biological Station Area, Keith and Garden Counties, Nebraska: Seasonal Occurrence and Breeding Data (1996)

Brown, Charles R., Brown, Mary Bomberger, Johnsgard, Paul A., Kren, Josef, Scharf, William C.

The North Platte River valley (elev. ca 3300 ft/990 m) in Garden and Keith counties, Nebraska, has an avifauna of 305 species, the richest known north of Texas in the Great Plains. More than 25 years...

Heritable basis for choice of group size in a colonial bird

Brown, Charles R., Brown, Mary Bomberger

Sizes of most kinds of animal groups vary considerably within a population, with group size often causing direct effects on the fitness of group members. Although the consequences of varying group...

Genetic Control of Experimental Lyme Arthritis in the Absence of Specific Immunity

Brown, Charles R., Reiner, Steven L.

Host genetics play an important role in determining resistance or susceptibility to experimental Lyme arthritis. While specific immunity appears to regulate disease resolution, innate immunity...

Protection of Macaques against Intrarectal Infection by a Combination Immunization Regimen with Recombinant Simian Immunodeficiency Virus SIVmne gp160 Vaccines

Polacino, Patricia, Stallard, Virginia, Montefiori, David C., Brown, Charles R., Richardson, Barbra A., Morton, William R., ...

We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against intravenous challenge by the cloned homologous...

Protection of Macaques against Pathogenic Simian/Human Immunodeficiency Virus 89.6PD by Passive Transfer of Neutralizing Antibodies

Mascola, John R., Lewis, Mark G., Stiegler, Gabriela, Harris, Dawn, VanCott, Thomas C., Hayes, Deborah, ...

The role of antibody in protection against human immunodeficiency virus (HIV-1) has been difficult to study in animal models because most primary HIV-1 strains do not infect nonhuman primates. Using...

Clearance of Borrelia burgdorferi May Not Be Required for Resistance to Experimental Lyme Arthritis

Brown, Charles R., Reiner, Steven L.

Infection of inbred mouse strains with Borrelia burgdorferi results in the development of experimental Lyme arthritis. The degree of arthritic pathology has been suggested to correlate with the level...

Activation of Natural Killer Cells in Arthritis-Susceptible but Not Arthritis-Resistant Mouse Strains following Borrelia burgdorferi Infection

Brown, Charles R., Reiner, Steven L.

Infection of susceptible mouse strains with Borrelia burgdorferi, the agent of Lyme disease, results in the development of arthritis. Components of the innate immune system may be important mediators...

Viral Genetic Evolution in Macaques Infected with Molecularly Cloned Simian Immunodeficiency Virus Correlates with the Extent of Persistent Viremia

Hirsch, Vanessa M., Dapolito, George, Hahn, Anna, Lifson, Jeff, Montefiori, David, Brown, Charles R., ...

Genetic evolution of the simian immunodeficiency virus (SIV) envelope glycoprotein was evaluated in a group of six macaques (Macaca nemestrina) infected with the molecularly cloned, moderately...

Comparative Efficacy of Recombinant Modified Vaccinia Virus Ankara Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol and/or Env in Macaques Challenged with Pathogenic SIV

Ourmanov, Ilnour, Brown, Charles R., Moss, Bernard, Carroll, Miles, Wyatt, Linda, Pletneva, Liuobov, ...

Prior studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided...

Intrinsic Susceptibility of Rhesus Macaque Peripheral CD4+ T Cells to Simian Immunodeficiency Virus In Vitro Is Predictive of In Vivo Viral Replication

Goldstein, Simoy, Brown, Charles R., Dehghani, Houman, Lifson, Jeffrey D., Hirsch, Vanessa M.

Previous studies with simian immunodeficiency virus (SIV) infection of rhesus macaques suggested that the intrinsic susceptibility of peripheral blood mononuclear cells (PBMC) to infection with SIV...

Wide Range of Viral Load in Healthy African Green Monkeys Naturally Infected with Simian Immunodeficiency Virus

Goldstein, Simoy, Ourmanov, Ilnour, Brown, Charles R., Beer, Brigitte E., Elkins, William R., Plishka, Ronald, ...

The distribution and levels of simian immunodeficiency virus (SIV) in tissues and plasma were assessed in naturally infected African green monkeys (AGM) of the vervet subspecies (Chlorocebus...

Biologic Studies of Chimeras of Highly and Moderately Virulent Molecular Clones of Simian Immunodeficiency Virus SIVsmPBj Suggest a Critical Role for Envelope in Acute AIDS Virus Pathogenesis

Haddrick, Malcolm, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M., Ginsberg, Harold

Previous studies identified three molecular clones of the acutely pathogenic SIVsmPBj strain that varied in terms of relative in vivo pathogenicity. One clone, SIVsmPBj6.6, reproducibly induced a...

Characterization of Novel Simian Immunodeficiency Viruses from Red-Capped Mangabeys from Nigeria (SIVrcmNG409 and -NG411)

Beer, Brigitte E., Foley, Brian T., Kuiken, Carla L., Tooze, Zena, Goeken, Robert M., Brown, Charles R., ...

Two novel simian immunodeficiency virus (SIV) strains from wild-caught red-capped mangabeys (Cercocebus torquatus torquatus) from Nigeria were characterized. Sequence analysis of the fully sequenced...

Experimental Lyme Arthritis in the Absence of Interleukin-4 or Gamma Interferon

Brown, Charles R., Reiner, Steven L.

Genetic resistance and susceptibility to experimental Lyme arthritis have been linked with the production of interleukin-4 (IL-4) or gamma interferon (IFN-γ), respectively. To determine the absolute...

Rapid and Irreversible CD4+ T-Cell Depletion Induced by the Highly Pathogenic Simian/Human Immunodeficiency Virus SHIVDH12R Is Systemic and Synchronous

Igarashi, Tatsuhiko, Brown, Charles R., Byrum, Russell A., Nishimura, Yoshiaki, Endo, Yasuyuki, Plishka, Ronald J., ...

Highly pathogenic simian/human immunodeficiency virus chimeric viruses are known to induce a rapid, irreversible depletion of CD4+ T lymphocytes in the peripheral blood of acutely infected macaque...

Immune Failure in the Absence of Profound CD4+ T-Lymphocyte Depletion in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques

Hirsch, Vanessa M., Santra, Sampa, Goldstein, Simoy, Plishka, Ronald, Buckler-White, Alicia, Seth, Aruna, ...

A fraction of simian immunodeficiency virus (SIV)-infected macaques develop rapidly progressive disease in the apparent absence of detectable SIV-specific antibody responses. To characterize the...

Induction of Simian AIDS in Infant Rhesus Macaques Infected with CCR5- or CXCR4-Utilizing Simian-Human Immunodeficiency Viruses Is Associated with Distinct Lesions of the Thymus

Reyes, R. A., Canfield, Don R., Esser, Ursula, Adamson, Lourdes A., Brown, Charles R., Cheng-Mayer, Cecilia, ...

Newborn rhesus macaques were infected with two chimeric simian-human immunodeficiency virus (SHIV) strains which contain unique human immunodeficiency virus type 1 (HIV-1) env genes and exhibit...

Treatment of Mice with the Neutrophil-Depleting Antibody RB6-8C5 Results in Early Development of Experimental Lyme Arthritis via the Recruitment of Gr-1− Polymorphonuclear Leukocyte-Like Cells

Brown, Charles R., Blaho, Victoria A., Loiacono, Christie M.

Recently, we demonstrated that blocking the entry of neutrophils into Borrelia burgdorferi-infected joints in mice deficient in the chemokine receptor CXCR2 prevented the development of experimental...

Plateau Levels of Viremia Correlate with the Degree of CD4+-T-Cell Loss in Simian Immunodeficiency Virus SIVagm-Infected Pigtailed Macaques: Variable Pathogenicity of Natural SIVagm Isolates

Goldstein, Simoy, Ourmanov, Ilnour, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Byrum, Russell, ...

Simian immunodeficiency virus from African green monkeys (SIVagm) results in asymptomatic infection in its natural host species. The virus is not inherently apathogenic, since infection of pigtailed...

Resting naïve CD4+ T cells are massively infected and eliminated by X4-tropic simian–human immunodeficiency viruses in macaques

Nishimura, Yoshiaki, Brown, Charles R., Mattapallil, Joseph J., Igarashi, Tatsuhiko, Buckler-White, Alicia, Lafont, Bernard A. P., ...

Unlike HIV-1 and simian immunodeficiency virus (SIV), which induce a slow, unrelenting loss of immune function spanning several years, highly pathogenic simian–human immunodeficiency viruses...

Immunodeficiency in the Absence of High Viral Load in Pig-Tailed Macaques Infected with Simian Immunodeficiency Virus SIVsun or SIVlhoest

Beer, Brigitte E., Brown, Charles R., Whitted, Sonya, Goldstein, Simoy, Goeken, Robert, Plishka, Ronald, ...

Simian immunodeficiency virus (SIV) is known to result in an asymptomatic infection of its natural African monkey host. However, some SIV strains are capable of inducing AIDS-like symptoms and death...

The ITAM in Nef Influences Acute Pathogenesis of AIDS-Inducing Simian Immunodeficiency Viruses SIVsm and SIVagm without Altering Kinetics or Extent of Viremia

Dehghani, Houman, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M.

The role of the immunoreceptor tyrosine-based activation motif (ITAM) that is unique to the Nef protein of the acutely pathogenic simian immunodeficiency virus SIVsmPBj was studied in the context of...

Infectious Molecular Clones from a Simian Immunodeficiency Virus-Infected Rapid-Progressor (RP) Macaque: Evidence of Differential Selection of RP-Specific Envelope Mutations In Vitro and In Vivo

Kuwata, Takeo, Dehghani, Houman, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Igarashi, Tatsuhiko, ...

A minor fraction of simian immunodeficiency virus (SIV)-infected macaques progress rapidly to AIDS in the absence of SIV-specific immune responses. Common mutations in conserved residues of env in...

Comparison of Simian Immunodeficiency Virus SIVagmVer Replication and CD4+ T-Cell Dynamics in Vervet and Sabaeus African Green Monkeys

Goldstein, Simoy, Brown, Charles R., Ourmanov, Ilnour, Pandrea, Ivona, Buckler-White, Alicia, Erb, Christopher, ...

The simian immunodeficiency viruses (SIV) naturally infect a wide range of African primates, including African green monkeys (AGM). Despite moderate to high levels of plasma viremia in naturally...

Heritable basis for choice of group size in a colonial bird

Brown, Charles R., Brown, Mary Bomberger

Sizes of most kinds of animal groups vary considerably within a population, with group size often causing direct effects on the fitness of group members. Although the consequences of varying group...

Genetic Control of Experimental Lyme Arthritis in the Absence of Specific Immunity

Brown, Charles R., Reiner, Steven L.

Host genetics play an important role in determining resistance or susceptibility to experimental Lyme arthritis. While specific immunity appears to regulate disease resolution, innate immunity...

Protection of Macaques against Intrarectal Infection by a Combination Immunization Regimen with Recombinant Simian Immunodeficiency Virus SIVmne gp160 Vaccines

Polacino, Patricia, Stallard, Virginia, Montefiori, David C., Brown, Charles R., Richardson, Barbra A., Morton, William R., ...

We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against intravenous challenge by the cloned homologous...

Protection of Macaques against Pathogenic Simian/Human Immunodeficiency Virus 89.6PD by Passive Transfer of Neutralizing Antibodies

Mascola, John R., Lewis, Mark G., Stiegler, Gabriela, Harris, Dawn, VanCott, Thomas C., Hayes, Deborah, ...

The role of antibody in protection against human immunodeficiency virus (HIV-1) has been difficult to study in animal models because most primary HIV-1 strains do not infect nonhuman primates. Using...

Clearance of Borrelia burgdorferi May Not Be Required for Resistance to Experimental Lyme Arthritis

Brown, Charles R., Reiner, Steven L.

Infection of inbred mouse strains with Borrelia burgdorferi results in the development of experimental Lyme arthritis. The degree of arthritic pathology has been suggested to correlate with the level...

Activation of Natural Killer Cells in Arthritis-Susceptible but Not Arthritis-Resistant Mouse Strains following Borrelia burgdorferi Infection

Brown, Charles R., Reiner, Steven L.

Infection of susceptible mouse strains with Borrelia burgdorferi, the agent of Lyme disease, results in the development of arthritis. Components of the innate immune system may be important mediators...

Viral Genetic Evolution in Macaques Infected with Molecularly Cloned Simian Immunodeficiency Virus Correlates with the Extent of Persistent Viremia

Hirsch, Vanessa M., Dapolito, George, Hahn, Anna, Lifson, Jeff, Montefiori, David, Brown, Charles R., ...

Genetic evolution of the simian immunodeficiency virus (SIV) envelope glycoprotein was evaluated in a group of six macaques (Macaca nemestrina) infected with the molecularly cloned, moderately...

Comparative Efficacy of Recombinant Modified Vaccinia Virus Ankara Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol and/or Env in Macaques Challenged with Pathogenic SIV

Ourmanov, Ilnour, Brown, Charles R., Moss, Bernard, Carroll, Miles, Wyatt, Linda, Pletneva, Liuobov, ...

Prior studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided...

Intrinsic Susceptibility of Rhesus Macaque Peripheral CD4+ T Cells to Simian Immunodeficiency Virus In Vitro Is Predictive of In Vivo Viral Replication

Goldstein, Simoy, Brown, Charles R., Dehghani, Houman, Lifson, Jeffrey D., Hirsch, Vanessa M.

Previous studies with simian immunodeficiency virus (SIV) infection of rhesus macaques suggested that the intrinsic susceptibility of peripheral blood mononuclear cells (PBMC) to infection with SIV...

Wide Range of Viral Load in Healthy African Green Monkeys Naturally Infected with Simian Immunodeficiency Virus

Goldstein, Simoy, Ourmanov, Ilnour, Brown, Charles R., Beer, Brigitte E., Elkins, William R., Plishka, Ronald, ...

The distribution and levels of simian immunodeficiency virus (SIV) in tissues and plasma were assessed in naturally infected African green monkeys (AGM) of the vervet subspecies (Chlorocebus...

Biologic Studies of Chimeras of Highly and Moderately Virulent Molecular Clones of Simian Immunodeficiency Virus SIVsmPBj Suggest a Critical Role for Envelope in Acute AIDS Virus Pathogenesis

Haddrick, Malcolm, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M., Ginsberg, Harold

Previous studies identified three molecular clones of the acutely pathogenic SIVsmPBj strain that varied in terms of relative in vivo pathogenicity. One clone, SIVsmPBj6.6, reproducibly induced a...

Characterization of Novel Simian Immunodeficiency Viruses from Red-Capped Mangabeys from Nigeria (SIVrcmNG409 and -NG411)

Beer, Brigitte E., Foley, Brian T., Kuiken, Carla L., Tooze, Zena, Goeken, Robert M., Brown, Charles R., ...

Two novel simian immunodeficiency virus (SIV) strains from wild-caught red-capped mangabeys (Cercocebus torquatus torquatus) from Nigeria were characterized. Sequence analysis of the fully sequenced...

Experimental Lyme Arthritis in the Absence of Interleukin-4 or Gamma Interferon

Brown, Charles R., Reiner, Steven L.

Genetic resistance and susceptibility to experimental Lyme arthritis have been linked with the production of interleukin-4 (IL-4) or gamma interferon (IFN-γ), respectively. To determine the absolute...

Rapid and Irreversible CD4+ T-Cell Depletion Induced by the Highly Pathogenic Simian/Human Immunodeficiency Virus SHIVDH12R Is Systemic and Synchronous

Igarashi, Tatsuhiko, Brown, Charles R., Byrum, Russell A., Nishimura, Yoshiaki, Endo, Yasuyuki, Plishka, Ronald J., ...

Highly pathogenic simian/human immunodeficiency virus chimeric viruses are known to induce a rapid, irreversible depletion of CD4+ T lymphocytes in the peripheral blood of acutely infected macaque...

The ITAM in Nef Influences Acute Pathogenesis of AIDS-Inducing Simian Immunodeficiency Viruses SIVsm and SIVagm without Altering Kinetics or Extent of Viremia

Dehghani, Houman, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M.

The role of the immunoreceptor tyrosine-based activation motif (ITAM) that is unique to the Nef protein of the acutely pathogenic simian immunodeficiency virus SIVsmPBj was studied in the context of...

Immune Failure in the Absence of Profound CD4+ T-Lymphocyte Depletion in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques

Hirsch, Vanessa M., Santra, Sampa, Goldstein, Simoy, Plishka, Ronald, Buckler-White, Alicia, Seth, Aruna, ...

A fraction of simian immunodeficiency virus (SIV)-infected macaques develop rapidly progressive disease in the apparent absence of detectable SIV-specific antibody responses. To characterize the...

Induction of Simian AIDS in Infant Rhesus Macaques Infected with CCR5- or CXCR4-Utilizing Simian-Human Immunodeficiency Viruses Is Associated with Distinct Lesions of the Thymus

Reyes, R. A., Canfield, Don R., Esser, Ursula, Adamson, Lourdes A., Brown, Charles R., Cheng-Mayer, Cecilia, ...

Newborn rhesus macaques were infected with two chimeric simian-human immunodeficiency virus (SHIV) strains which contain unique human immunodeficiency virus type 1 (HIV-1) env genes and exhibit...

Treatment of Mice with the Neutrophil-Depleting Antibody RB6-8C5 Results in Early Development of Experimental Lyme Arthritis via the Recruitment of Gr-1− Polymorphonuclear Leukocyte-Like Cells

Brown, Charles R., Blaho, Victoria A., Loiacono, Christie M.

Recently, we demonstrated that blocking the entry of neutrophils into Borrelia burgdorferi-infected joints in mice deficient in the chemokine receptor CXCR2 prevented the development of experimental...

Plateau Levels of Viremia Correlate with the Degree of CD4+-T-Cell Loss in Simian Immunodeficiency Virus SIVagm-Infected Pigtailed Macaques: Variable Pathogenicity of Natural SIVagm Isolates

Goldstein, Simoy, Ourmanov, Ilnour, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Byrum, Russell, ...

Simian immunodeficiency virus from African green monkeys (SIVagm) results in asymptomatic infection in its natural host species. The virus is not inherently apathogenic, since infection of pigtailed...

Resting naïve CD4+ T cells are massively infected and eliminated by X4-tropic simian–human immunodeficiency viruses in macaques

Nishimura, Yoshiaki, Brown, Charles R., Mattapallil, Joseph J., Igarashi, Tatsuhiko, Buckler-White, Alicia, Lafont, Bernard A. P., ...

Unlike HIV-1 and simian immunodeficiency virus (SIV), which induce a slow, unrelenting loss of immune function spanning several years, highly pathogenic simian–human immunodeficiency viruses...

Immunodeficiency in the Absence of High Viral Load in Pig-Tailed Macaques Infected with Simian Immunodeficiency Virus SIVsun or SIVlhoest

Beer, Brigitte E., Brown, Charles R., Whitted, Sonya, Goldstein, Simoy, Goeken, Robert, Plishka, Ronald, ...

Simian immunodeficiency virus (SIV) is known to result in an asymptomatic infection of its natural African monkey host. However, some SIV strains are capable of inducing AIDS-like symptoms and death...

Infectious Molecular Clones from a Simian Immunodeficiency Virus-Infected Rapid-Progressor (RP) Macaque: Evidence of Differential Selection of RP-Specific Envelope Mutations In Vitro and In Vivo

Kuwata, Takeo, Dehghani, Houman, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Igarashi, Tatsuhiko, ...

A minor fraction of simian immunodeficiency virus (SIV)-infected macaques progress rapidly to AIDS in the absence of SIV-specific immune responses. Common mutations in conserved residues of env in...

Comparison of Simian Immunodeficiency Virus SIVagmVer Replication and CD4+ T-Cell Dynamics in Vervet and Sabaeus African Green Monkeys

Goldstein, Simoy, Brown, Charles R., Ourmanov, Ilnour, Pandrea, Ivona, Buckler-White, Alicia, Erb, Christopher, ...

The simian immunodeficiency viruses (SIV) naturally infect a wide range of African primates, including African green monkeys (AGM). Despite moderate to high levels of plasma viremia in naturally...

Phylogenetic Analysis of Buggy Creek Virus: Evidence for Multiple Clades in the Western Great Plains, United States of America▿

Pfeffer, Martin , Foster, Jerome E., Edwards, Eric A., Brown, Mary Bomberger, Komar, Nicholas, Brown, Charles R.

We present the first detailed phylogenetic analysis of Buggy Creek virus (BCRV), a poorly known alphavirus with transmission cycles involving a cimicid swallow bug (Oeciacus vicarius) vector and...

Spleen volume varies with colony size and parasite load in a colonial bird.

Brown, Charles R, Bomberger Brown, Mary

Comparisons across bird species have indicated that those more exposed to parasites and pathogens invest more in immunological defence, as measured by spleen size. We investigated how spleen volume...