ABO Blood Group and the Risk of Pancreatic Cancer (2009)
Wolpin, Brian M., Chan, Andrew T., Hartge, Patricia, Chanock, Stephen J., Kraft, Peter, Hunter, David J., ...
Background Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in...
Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...
Abstract Background Cyclooxygenase-2 (COX-2, PTGS2 ) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite...
A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer (2008)
Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Kawasaki, Takako, Chan, Andrew T., Schernhammer, Eva S., ...
Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome...
Fruits, Vegetables, and Colon Cancer Risk in a Pooled Analysis of 14 Cohort Studies (2007)
Koushik, Anita, Hunter, David J., Spiegelman, Donna, Beeson, W. Lawrence, Van Den Brandt, Piet A., Buring, Julie E., ...
Background Fruit and vegetable intakes have been associated with a reduced risk of colon cancer; however, in more recent studies associations have been less consistent. Statistical power to examine...
Ogino, Shuji, Hazra, Aditi, Tranah, Gregory J., Kirkner, Gregory J., Kawasaki, Takako, Nosho, Katsuhiko, ...
O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may...
Dietary Choline and Betaine and the Risk of Distal Colorectal Adenoma in Women (2007)
Cho, Eunyoung, Willett, Walter C., Colditz, Graham A., Fuchs, Charles S., Wu, Kana, Chan, Andrew T., ...
Background Choline and betaine are involved in methyl-group metabolism as methyl-group donors; thus, like folate, another methyl-group donor, they may be associated with a reduced risk of colorectal...
Wu, Kana, Feskanich, Diane, Fuchs, Charles S., Willett, Walter C., Hollis, Bruce W., Giovannucci, Edward L.
Background Low vitamin D status has long been implicated in colorectal carcinogenesis. We investigated this relationship in a nested case–control study within the Health Professionals Follow-up...
Hazra, Aditi, Wu, Kana, Kraft, Peter, Fuchs, Charles S., Giovannucci, Edward L., Hunter, David J.
Dietary folate and alcohol consumption as well as polymorphic variants in one-carbon metabolism genes may modulate risk of colorectal adenoma through aberrant DNA methylation and altered nucleotide...
Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J, Ohnishi, Mutsuko, Fuchs, Charles S
Abstract Background: The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite...
Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies (2007)
Mannisto, Satu, Yaun, Shiaw-Shyuan, Hunter, David J., Spiegelman, Donna, Adami, Hans-Olov, Albanes, Demetrius, ...
Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies (2007)
Koushik, Anita, Hunter, David J., Spiegelman, Donna, Beeson, W. Lawrence, Buring, Julie E., ...
Michaud, Dominique S., Joshipura, Kaumudi, Giovannucci, Edward, Fuchs, Charles S.
Two previous cohort studies reported positive associations between tooth loss or periodontitis and pancreatic cancer risk. Data on periodontal disease were obtained at baseline and every other year...
Dietary Carotenoids and Risk of Colorectal Cancer in a Pooled Analysis of 11 Cohort Studies (2007)
Männistö, Satu, Yaun, Shiaw-Shyuan, Hunter, David J., Spiegelman, Donna, Adami, Hans-Olov, Albanes, Demetrius, ...
Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene,...
Calcium and Vitamin D Intakes in Relation to Risk of Distal Colorectal Adenoma in Women (2007)
Oh, Kyungwon, Willett, Walter C., Wu, Kana, Fuchs, Charles S., Giovannucci, Edward L.
The authors examined intakes of calcium and vitamin D, and interaction with retinol, in relation to risk of adenoma of the distal colon or rectum among 48,115 US women who were free of colorectal...
Calcium and Vitamin D Intakes in Relation to Risk of Distal Colorectal Adenoma in Women (2007)
Oh, Kyungwon, Willett, Walter C., Wu, Kana, Fuchs, Charles S., Giovannucci, Edward L.
The authors examined intakes of calcium and vitamin D, and interaction with retinol, in relation to risk of adenoma of the distal colon or rectum among 48,115 US women who were free of colorectal...
Kwak, Eunice L., Jankowski, Janusz, Thayer, Sarah P., Lauwers, Gregory Y., Brannigan, Brian W., Harris, Patricia L., ...
PURPOSE: Specific activating mutations within the epidermal growth factor receptor (EGFR) identify a subset of non-small cell lung cancers with dramatic sensitivity to the specific tyrosine kinase...
Flavonoid Intake and Colorectal Cancer Risk in Men and Women (2006)
Lin, Jennifer, Zhang, Shumin M., Wu, Kana, Willett, Walter C., Fuchs, Charles S., Giovannucci, Edward
Dietary flavonoids can inhibit cancer development by protecting tissues against free oxygen radicals and inhibiting cell proliferation, but observational studies of flavonoid intake and colorectal...
Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men (2006)
Giovannucci, Edward, Liu, Yan, Rimm, Eric B., Hollis, Bruce W., Fuchs, Charles S., Stampfer, Meir J., ...
Background: Vitamin D has potent anticancer properties, especially against digestive-system cancers. Many human studies have used geographic residence as a marker of solar ultraviolet B and hence...
Coffee, Tea, and Caffeine Consumption and Incidence of Colon and Rectal Cancer (2005)
Michels, Karin B., Willett, Walter C., Fuchs, Charles S., Giovannucci, Edward
Background: Frequent coffee consumption has been associated with a reduced risk of colorectal cancer in a number of case–control studies. Cohort studies have not revealed such an association but...
Low Plasma Adiponectin Levels and Risk of Colorectal Cancer in Men: A Prospective Study (2005)
Wei, Esther K., Giovannucci, Edward, Fuchs, Charles S., Willett, Walter C., Mantzoros, Christos S.
Background: Adiponectin is an insulin-sensitizing hormone secreted by adipocytes. Levels of adiponectin are inversely associated with adiposity and insulin resistance. Because both adiposity and...
Genetic Variants in the UGT1A6 Enzyme, Aspirin Use, and the Risk of Colorectal Adenoma (2005)
Chan, Andrew T., Tranah, Gregory J., Giovannucci, Edward L., Hunter, David J., Fuchs, Charles S.
Genetic variation in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) enzyme is associated with impaired metabolism of aspirin. To determine whether polymorphisms in the UGT1A6 enzyme...
Dietary Patterns and Pancreatic Cancer Risk in Men and Women (2005)
Michaud, Dominique S., Skinner, Halcyon G., Wu, Kana, Hu, Frank, Giovannucci, Edward, Willett, Walter C., ...
Background: Diabetes appears to be associated with the development of pancreatic cancer. Three large prospective cohort studies observed a statistically significant relationbetween obesity and...
Plasma Vitamin B6 and the Risk of Colorectal Cancer and Adenoma in Women (2005)
Wei, Esther K., Giovannucci, Edward, Selhub, Jacob, Fuchs, Charles S., Hankinson, Susan E., Ma, Jing
Background: Vitamin B6, whose main circulating form is pyridoxal 5′-phosphate (PLP), is important in one-carbon metabolism, which is critical for DNA synthesis and DNA methylation, both of which...
Chan, Andrew T., Ma, Jing, Tranah, Gregory J., Giovannucci, Edward L., Rifai, Nader, Hunter, David J., ...
Background: Some experimental evidence suggests that iron may play a role in colorectal carcinogenesis, but human data for this role have been conflicting, possibly because of problems related to...
A Prospective Study of Folate Intake and the Risk of Pancreatic Cancer in Men and Women (2004)
Skinner, Halcyon G., Michaud, Dominique S., Giovannucci, Edward L., Rimm, Eric B., Stampfer, Meir J., Willett, Walter C., ...
Laboratory and human studies suggest that folate intake may influence the risk of some cancers. However, prospective information about the relation between folate intake and the risk of exocrine...
A Prospective Study of Aspirin Use and the Risk of Pancreatic Cancer in Women (2004)
Schernhammer, Eva S., Kang, Jae-Hee, Chan, Andrew T., Michaud, Dominique S., Skinner, Halcyon G., Giovannucci, Edward, ...
Background: In vitro experiments and limited animal studies suggest that aspirin and nonsteroidal anti-inflammatory drugs may inhibit pancreatic carcinogenesis. Because few studies have examined the...
Relation of Hospital Volume to Colostomy Rates and Survival for Patients With Rectal Cancer (2003)
Hodgson, David C., Zhang, Wei, Zaslavsky, Alan M., Fuchs, Charles S., Wright, William E., Ayanian, John Z.
Background: Postoperative mortality after some types of cancer surgery is inversely related to the number of operations performed at a hospital (i.e., hospital volume). This study assessed the...
Night-Shift Work and Risk of Colorectal Cancer in the Nurses Health Study (2003)
Schernhammer, Eva S., Laden, Francine, Speizer, Frank E., Willett, Walter C., Hunter, David J., Kawachi, Ichiro, ...
Exposure to light at night suppresses the physiologic production of melatonin, a hormone that has antiproliferative effects on intestinal cancers. Although observational studies have associated...
Michaud, Dominique S., Giovannucci, Edward, Willett, Walter C., Colditz, Graham A., Fuchs, Charles S.
Case-control studies suggest that meat and cholesterol intakes may be related to elevated risks of pancreatic cancer. Few prospective studies have examined associations between diet and pancreatic...
Calcium Intake and Risk of Colon Cancer in Women and Men (2002)
Wu, Kana, Willett, Walter C., Fuchs, Charles S., Colditz, Graham A., Giovannucci, Edward L.
Background: Calcium has been hypothesized to reduce the risk of colon cancer, and in a recent randomized trial, calcium supplementation was associated with reduction in the risk of recurrent...
Dietary Sugar, Glycemic Load, and Pancreatic Cancer Risk in a Prospective Study (2002)
Michaud, Dominique S., Liu, Simin, Giovannucci, Edward, Willett, Walter C., Colditz, Graham A., Fuchs, Charles S.
Background: Evidence from both animal and human studies suggests that abnormal glucose metabolism plays an important role in pancreatic carcinogenesis. We investigated whether diets high in foods...
McCollum, A. David, Catalano, Paul J., Haller, Daniel G., Mayer, Robert J., Macdonald, John S., Benson, Al B., ...
Background: Previous studies have demonstrated that African-Americans with colon cancer have worse overall and stage-specific survival rates than Caucasians. Such differences could reflect variation...
Prospective Study of Recreational Physical Activity and Ovarian Cancer (2001)
Bertone, Elizabeth R., Willett, Walter C., Rosner, Bernard A., Hunter, David J., Fuchs, Charles S., Speizer, Frank E., ...
Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer (2001)
Michaud, Dominique S., Giovannucci, Edward, Willett, Walter C., Colditz, Graham A., Stampfer, Meir J., Fuchs, Charles S.
Prospective Study of Recreational Physical Activity and Ovarian Cancer (2001)
Bertone, Elizabeth R., Willett, Walter C., Rosner, Bernard A., Hunter, David J., Fuchs, Charles S., Speizer, Frank E., ...
Background: It has been hypothesized that physical activity may reduce the risk of ovarian cancer by decreasing estrogen levels, reducing body fat, and reducing the frequency of ovulation....
Hodgson, David C., Fuchs, Charles S., Ayanian, John Z.
While the management and prognosis of colorectal cancer are largely dependent on clinical features such as tumor stage, there is considerable variation in treatment and outcome not explained by...
Prospective Study of Bowel Movement, Laxative Use, and Risk of Colorectal Cancer among Women (2000)
Dukas, Laurent, Willett, Walter C., Colditz, Graham A., Fuchs, Charles S., Rosner, Bernard, Giovannucci, Edward L.
The authors prospectively examined the association between bowel movement frequency, laxative use, and the risk of colorectal cancer in 84, 577 women of the Nurses' Health Study living in the United...
Michels, Karin B., Edward Giovannucci,, Joshipura, Kaumudi J., Rosner, Bernard A., Stampfer, Meir J., Fuchs, Charles S., ...
Background: Frequent consumption of fruit and vegetables has been associated with a reduced risk of colorectal cancer in many observational studies. Methods: We prospectively investigated the...
Ogino, Shuji, Brahmandam, Mohan, Kawasaki, Takako, Kirkner, Gregory J, Loda, Massimo, Fuchs, Charles S
Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability—high (MSI-H) and CpG island methylator phenotype...
Ogino, Shuji, Brahmandam, Mohan, Kawasaki, Takako, Kirkner, Gregory J, Loda, Massimo, Fuchs, Charles S
Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability—high (MSI-H) and CpG island methylator phenotype...
Sensitive Sequencing Method for KRAS Mutation Detection by Pyrosequencing
Ogino, Shuji, Kawasaki, Takako, Brahmandam, Mohan, Yan, Liying, Cantor, Mami, Namgyal, Chungdak, ...
Both benign and malignant tumors represent heterogenous tissue containing tumor cells and non-neoplastic mesenchymal and inflammatory cells. To detect a minority of mutant KRAS alleles among abundant...
Ogino, Shuji, Kawasaki, Takako, Brahmandam, Mohan, Cantor, Mami, Kirkner, Gregory J., Spiegelman, Donna, ...
Assays to measure DNA methylation, which are important in epigenetic research and clinical diagnostics, typically rely on conversion of unmethylated cytosine to uracil by sodium bisulfite. However,...
Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Dehari, Reiko, ...
The WNT/β-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested....
Impact of Hospital Volume on Recurrence and Survival After Surgery for Gastric Cancer
Enzinger, Peter C., Benedetti, Jacqueline K., Meyerhardt, Jeffrey A., McCoy, Sheryl, Hundahl, Scott A., Macdonald, John S., ...
This study evaluates the impact of hospital volume, as a proxy of surgical expertise, on recurrence and survival in patients who enrolled in U.S. Intergroup 0116, a randomized study that compared...
Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J., Loda, Massimo, Fuchs, Charles S.
The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter methylation seems to be a distinct epigenotype of colorectal cancer. However, no study has comprehensively examined...
Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Fuchs, Charles S, ...
Insulin-like growth factor binding protein 3 (IGFBP3), which is induced by wild-type p53, regulates IGF and interacts with the TGF-β pathway. IGFBP3 promoter methylation may occur in colorectal...
Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, ...
PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations1
Nosho, Katsuhiko, Kawasaki, Takako, Ohnishi, Mutsuko, Suemoto, Yuko, Kirkner, Gregory J, Zepf, Dimity, ...
Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island...
Ogino, Shuji, Kawasaki, Takako, Kirkner, Gregory J., Kraft, Peter, Loda, Massimo, Fuchs, Charles S.
The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter methylation is a distinct phenotype in colorectal cancer. However, a choice of markers for CIMP has been controversial....
DNA Degradation Test Predicts Success in Whole-Genome Amplification from Diverse Clinical Samples
Wang, Fengfei, Wang, Lilin, Briggs, Christine, Sicinska, Ewa, Gaston, Sandra M., Mamon, Harvey, ...
The need to apply modern technologies to analyze DNA from diverse clinical samples often stumbles on suboptimal sample quality. We developed a simple approach to assess DNA fragmentation in minute...
Nosho, Katsuhiko, Irahara, Natsumi, Shima, Kaori, Kure, Shoko, Kirkner, Gregory J., Schernhammer, Eva S., ...
Nosho, Katsuhiko, Shima, Kaori, Kure, Shoko, Irahara, Natsumi, Baba, Yoshifumi, Chen, Li, ...
JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG...
Aurora-A Expression Is Independently Associated with Chromosomal Instability in Colorectal Cancer1
Baba, Yoshifumi, Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Toyoda, Saori, ...
AURKA (the official symbol for Aurora-A, STK15, or BTAK) regulates the function of centrosomes, spindles, and kinetochores for proper mitotic progression. AURKA overexpression is observed in various...