Charles Vinson

Letter Clustering of DNA Sequences in Human Promoters (2008)

Peter C. Fitzgerald, Andrey Shlyakhtenko, Alain A. Mir, Charles Vinson

We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative...

All and only CpG containing sequences are enriched in promoters abundantly bound by RNA polymerase II in multiple tissues (2008)

Rozenberg, Julian M, Shlyakhtenko, Andrey, Glass, Kimberly, Rishi, Vikas, Myakishev, Maxim V, FitzGerald, Peter C, ...

Abstract Background The promoters of housekeeping genes are well-bound by RNA polymerase II (RNAP) in different tissues. Although the promoters of these genes are known to contain CpG islands, the...

Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin (2007)

Oh, Won-Jun, Rishi, Vikas, Pelech, Steven, Vinson, Charles

We have used a two-transgene tetracycline system to reversibly express oncogenic H-RasV12G in mouse skin and primary keratinocytes culture using the bovine keratin 5 promoter. Induction of H-RasV12G...

Comparative genomics of Drosophilaand human core promoters (2006)

FitzGerald, Peter C, Sturgill, David, Shyakhtenko, Andrey, Oliver, Brian, Vinson, Charles

Abstract Background The core promoter region plays a critical role in the regulation of eukaryotic gene expression. We have determined the non-random distribution of DNA sequences relative to the...

Clustering of DNA Sequences in Human Promoters (2004)

FitzGerald, Peter C., Shlyakhtenko, Andrey, Mir, Alain A., Vinson, Charles

We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative...

Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs (2004)

Deppmann, Christopher D., Acharya, Asha, Rishi, Vikas, Wobbes, Barry, Smeekens, Sjef, Taparowsky, Elizabeth J., ...

Basic region-leucine zipper (B-ZIP) proteins are a class of dimeric sequence-specific DNA-binding proteins unique to eukaryotes. We have identified 67 B-ZIP proteins in the Arabidopsis thaliana...

Clustering of DNA Sequences in Human Promoters (2004)

FitzGerald, Peter C., Shlyakhtenko, Andrey, Mir, Alain A., Vinson, Charles

We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative...

Magnesium is required for specific DNA binding of the CREB B-ZIP domain (2002)

Moll, Jonathan R., Acharya, Asha, Gal, Jozset, Mir, Alain A., Vinson, Charles

We have examined binding of the CREB B-ZIP protein domain to double-stranded DNA containing a consensus CRE sequence (5′-TGACGTCA-3′), the related PAR, C/EBP and AP-1 sequences and the...

[Doctoral thesis recital, Apr. 21, 1989, piano]--[sound recording] /--Charles Vinson. (1989)

Vinson, Charles.

VHS format; special digital audio processing equipment required for reproduction.

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...

We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...

A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding

Krylov, Dmitry, Kasai, Kenji, Echlin, Deborah R., Taparowsky, Elizabeth J., Arnheiter, Heinz, Vinson, Charles

We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns...

Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins

Greenwel, Patricia, Tanaka, Shizuko, Penkov, Dmitri, Zhang, Wen, Olive, Michelle, Moll, Jonathan, ...

Extracellular matrix (ECM) formation and remodeling are critical processes for proper morphogenesis, organogenesis, and tissue repair. The proinflammatory cytokine tumor necrosis factor alpha...

Magnesium is required for specific DNA binding of the CREB B-ZIP domain

Moll, Jonathan R., Acharya, Asha, Gal, Jozset, Mir, Alain A., Vinson, Charles

We have examined binding of the CREB B-ZIP protein domain to double-stranded DNA containing a consensus CRE sequence (5′-TGACGTCA-3′), the related PAR, C/EBP and AP-1 sequences and the unrelated...

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

Ahn, Sohyun, Olive, Michelle, Aggarwal, Seema, Krylov, Dmitry, Ginty, David D., Vinson, Charles

Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for c-fos...

Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation

Qyang, Yibing, Luo, Xu, Lu, Tao, Ismail, Preeti M., Krylov, Dmitry, Vinson, Charles, ...

USF1 and USF2 are basic helix-loop-helix transcription factors implicated in the control of cellular proliferation. In HeLa cells, the USF proteins are transcriptionally active and their...

B-ZIP Proteins Encoded by the Drosophila Genome: Evaluation of Potential Dimerization Partners

Fassler, Jan, Landsman, David, Acharya, Asha, Moll, Jonathan R., Bonovich, Maria, Vinson, Charles

The basic region-leucine zipper (B-ZIP) (bZIP) protein motif dimerizes to bind specific DNA sequences. We have identified 27 B-ZIP proteins in the recently sequenced Drosophila melanogaster genome....

Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes

Zhang, Jiang-Wen, Tang, Qi-Qun, Vinson, Charles, Lane, M. Daniel

Hormonal induction of growth-arrested 3T3-L1 preadipocytes rapidly activates expression of CCAAT/enhancer-binding protein (C/EBP) β. Acquisition of DNA-binding activity by C/EBPβ, however, is...

Life without white fat: a transgenic mouse

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...

In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, ...

There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue...

Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs

Deppmann, Christopher D., Acharya, Asha, Rishi, Vikas, Wobbes, Barry, Smeekens, Sjef, Taparowsky, Elizabeth J., ...

Basic region-leucine zipper (B-ZIP) proteins are a class of dimeric sequence-specific DNA-binding proteins unique to eukaryotes. We have identified 67 B-ZIP proteins in the Arabidopsis thaliana...

Clustering of DNA Sequences in Human Promoters

FitzGerald, Peter C., Shlyakhtenko, Andrey, Mir, Alain A., Vinson, Charles

We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative...

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...

We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...

A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding

Krylov, Dmitry, Kasai, Kenji, Echlin, Deborah R., Taparowsky, Elizabeth J., Arnheiter, Heinz, Vinson, Charles

We describe a method to design dominant-negative proteins (D-N) to the basic helix–loop–helix–leucine zipper (B-HLHZip) family of sequence-specific DNA binding transcription factors. The D-Ns...

Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins

Greenwel, Patricia, Tanaka, Shizuko, Penkov, Dmitri, Zhang, Wen, Olive, Michelle, Moll, Jonathan, ...

Extracellular matrix (ECM) formation and remodeling are critical processes for proper morphogenesis, organogenesis, and tissue repair. The proinflammatory cytokine tumor necrosis factor alpha...

Magnesium is required for specific DNA binding of the CREB B-ZIP domain

Moll, Jonathan R., Acharya, Asha, Gal, Jozset, Mir, Alain A., Vinson, Charles

We have examined binding of the CREB B-ZIP protein domain to double-stranded DNA containing a consensus CRE sequence (5′-TGACGTCA-3′), the related PAR, C/EBP and AP-1 sequences and the unrelated...

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

Ahn, Sohyun, Olive, Michelle, Aggarwal, Seema, Krylov, Dmitry, Ginty, David D., Vinson, Charles

Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for c-fos...

Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation

Qyang, Yibing, Luo, Xu, Lu, Tao, Ismail, Preeti M., Krylov, Dmitry, Vinson, Charles, ...

USF1 and USF2 are basic helix-loop-helix transcription factors implicated in the control of cellular proliferation. In HeLa cells, the USF proteins are transcriptionally active and their...

B-ZIP Proteins Encoded by the Drosophila Genome: Evaluation of Potential Dimerization Partners

Fassler, Jan, Landsman, David, Acharya, Asha, Moll, Jonathan R., Bonovich, Maria, Vinson, Charles

The basic region-leucine zipper (B-ZIP) (bZIP) protein motif dimerizes to bind specific DNA sequences. We have identified 27 B-ZIP proteins in the recently sequenced Drosophila melanogaster genome....

Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes

Zhang, Jiang-Wen, Tang, Qi-Qun, Vinson, Charles, Lane, M. Daniel

Hormonal induction of growth-arrested 3T3-L1 preadipocytes rapidly activates expression of CCAAT/enhancer-binding protein (C/EBP) β. Acquisition of DNA-binding activity by C/EBPβ, however, is...

Life without white fat: a transgenic mouse

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...

In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

Chao, Lily, Marcus-Samuels, Bernice, Mason, Mark M., Moitra, Jaideep, Vinson, Charles, Arioglu, Elif, ...

There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue...

Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs

Deppmann, Christopher D., Acharya, Asha, Rishi, Vikas, Wobbes, Barry, Smeekens, Sjef, Taparowsky, Elizabeth J., ...

Basic region-leucine zipper (B-ZIP) proteins are a class of dimeric sequence-specific DNA-binding proteins unique to eukaryotes. We have identified 67 B-ZIP proteins in the Arabidopsis thaliana...

Clustering of DNA Sequences in Human Promoters

FitzGerald, Peter C., Shlyakhtenko, Andrey, Mir, Alain A., Vinson, Charles

We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative...

Comparative genomics of Drosophila and human core promoters

FitzGerald, Peter C, Sturgill, David, Shyakhtenko, Andrey, Oliver, Brian, Vinson, Charles

Comparison of DNA sequence distributions in Drosophila and human promoters suggests that different motifs have distinct functional roles.

Hypotension, lipodystrophy, and insulin resistance in generalized PPARγ-deficient mice rescued from embryonic lethality

Duan, Sheng Zhong, Ivashchenko, Christine Y., Whitesall, Steven E., D’Alecy, Louis G., Duquaine, Damon C., Brosius, Frank C., ...

We rescued the embryonic lethality of global PPARγ knockout by breeding Mox2-Cre (MORE) mice with floxed PPARγ mice to inactivate PPARγ in the embryo but not in trophoblasts and created a...

Reciprocal Roles for CCAAT/Enhancer Binding Protein (C/EBP) and PU.1 Transcription Factors in Langerhans Cell Commitment

Iwama, Atsushi, Osawa, Mitsujiro, Hirasawa, Ryutaro, Uchiyama, Noriko, Kaneko, Shin, Onodera, Masafumi, ...

Myeloid progenitor cells give rise to a variety of progenies including dendritic cells. However, the mechanism controlling the diversification of myeloid progenitors into each progeny is largely...

Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10−15 M

Moll, Jonathan R., Ruvinov, Sergei B., Pastan, Ira, Vinson, Charles

We have designed a heterodimerizing leucine zipper system to target a radionuclide to prelocalized noninternalizing tumor-specific antibodies. The modular nature of the leucine zipper allows us to...

CAATT/Enhancer-binding Proteins α and δ Interact with NKX2-1 to Synergistically Activate Mouse Secretoglobin 3A2 Gene Expression*S⃞

Tomita, Takeshi, Kido, Taketomo, Kurotani, Reiko, Iemura, Shun-ichiro, Sterneck, Esta, Natsume, Tohru, ...

Secretoglobin (SCGB) 3A2 is a small molecular weight secreted protein predominantly expressed in lung airways. We previously demonstrated that the expression of SCGB3A2 is regulated by homeodomain...

Opposing Roles for ATF2 and c-Fos in c-Jun-Mediated Neuronal Apoptosis▿

Yuan, Zhongmin, Gong, Shoufang, Luo, Jingyan, Zheng, Zhihao, Song, Bin, Ma, Shanshan, ...

The activator protein 1 (AP-1) transcription factor c-Jun is crucial for neuronal apoptosis. However, c-Jun dimerization partners and the regulation of these proteins in neuronal apoptosis remain...