Chen Wang

Publication List Details

Period

1927 - 2009

Number

121

Co-Authors

Polarization Changes of Pulsars due to Wave Propagation Through Magnetospheres (2009)

Wang, Chen, Lai, Dong, Han, JinLin

We study the propagation effects of radio waves in a pulsar magnetosphere, composed of relativistic electron-positron pair plasmas streaming along the magnetic field lines and corotating with the...

MDS++: Supporting Ontology-based Dynamic (2009)

Classification Websphere, Metadata Server, Shengping Liu, Yang Yang, Guotong Xie, Chen Wang, ...

Metadata management systems are growing from tool-specific repositories to enterprise-wide metadata repositories. In this context, one challenge is the management of the evolving metadata whose...

Polarized X-rays from Magnetized Neutron Stars (2009)

Lai, Dong, Ho, Wynn C. G., Van Adelsberg, Matthew, Wang, Chen, Heyl, Jeremy S.

We review the polarization properties of X-ray emission from highly magnetized neutron stars, focusing on emission from the stellar surfaces. We discuss how x-ray polarization can be used to...

Polarization Evolution in A Strongly Magnetized Vacuum: QED Effect and Polarized X-ray Emission from Magnetized Neutron Stars (2009)

Wang, Chen, Lai, Dong

X-ray photons emitted from the surface or atmosphere of a magnetized neutron star is highly polarized. However, the observed polarization may be modified due to photon propagation through the star's...

Defending P2Ps from Overlay Flooding-based DDoS (2009)

Yunhao Liu, Xiaomei Liu, Chen Wang, Li Xiao

A flooding-based search mechanism is often used in unstructured P2P systems. Although a flooding-based search mechanism is simple and easy to implement, it is vulnerable to overlay distributed...

Identification of molecular flipping of an asymmetric tris(phthalocyaninato) lutetium triple-decker complex by scanning tunneling microscopy/spectroscopy (2009)

Kong, Xianghua, Lei, Shengbin, Yang, Yanlian, Deng, Ke, Qi, Guicun, Wang, Chen

The assembling behavior and electronic properties of asymmetric tris(phthalocyaninato) lutetium tripledecker sandwich complex molecules (Lu2Pc3) on highly oriented pyrolytic graphite (HOPG) surfaces...

7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-d-glycero-d-manno-heptonamide (2009)

Sarah F. Jenkinson, Chen Wang, David J. Watkin

The reaction of 5-azido-5-deoxy-2,3-O-isopropylidene-2-C-methyl-d-ribose with N,N-diethyl-2-(dimethylsulfuranylidene)acetamide gave the title compound, C15H26N4O5, as the major product arising from...

Large-scale 3D environmental modelling and visualisation for flood hazard warning. (2009)

Wang, Chen

3D environment reconstruction has received great interest in recent years in areas such as city planning, virtual tourism and flood hazard warning. With the rapid development of computer...

ADenTS: An Adaptive Density-based Tree Structure for Approximating Aggregate Queries over Real Attributes ⋆ (2008)

Tianyi Wu, Jian Xu, Chen Wang, Wei Wang, Baile Shi

Abstract. In many fields and applications, it is critical for users to make decisions through OLAP queries. How to promote accuracy and efficiency while answering multiple aggregate queries, e.g....

DiCAS: An efficient distributed caching mechanism for P2P systems (2008)

Chen Wang, Student Member, Li Xiao, Yunhao Liu, Pei Zheng

Abstract—Peer-to-peer networks are widely criticized for their inefficient flooding search mechanism. Distributed Hash Table (DHT) algorithms have been proposed to improve the search efficiency by...

Defending P2Ps from Overlay Flooding-based DDoS (2008)

Yunhao Liu, Xiaomei Liu, Chen Wang, Li Xiao

A flooding-based search mechanism is often used in unstructured P2P systems. Although a flooding-based search mechanism is simple and easy to implement, it is vulnerable to overlay distributed...

On Approximate Optimal Dual Power Assignment for Biconnectivity and Edge-Biconnectivity ∗ (2008)

Chen Wang, Myung-ah Park, James Willson, Yongxi Cheng, Andras Farago, Weili Wu

Topology control is one of the major approaches to achieve the energy efficiency as well as fault tolerance in wireless networks. In this paper, we study the dual power assignment problem for 2-edge...

JCB: ARTICLE (2008)

Danyang Chen, Miroslav Dundr, Chen Wang, Anthony Leung, Angus Lamond, Tom Misteli, ...

Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins 1 2

Adaptively Routing P2P Queries Using Association Analysis (2008)

Brian D. Connelly, Christopher W. Bowron, Li Xiao, Pang-ning Tan, Chen Wang

Unstructured peer-to-peer networks have become a very popular method for content distribution in the past few years. By not enforcing strict rules on the network’s topology or content location,...

A Connectivity Based Partition Approach for Node Scheduling in Sensor Networks (2008)

Yong Ding, Chen Wang, Li Xiao

Abstract. This paper presents a Connectivity based Partition Approach (CPA) to reduce the energy consumption of a sensor network by sleep scheduling among sensor nodes. CPA partitions sensors into...

Knowledge-guided multi-scale independent component analysis for biomarker identification (2008)

Chen, Li, Xuan, Jianhua, Wang, Chen, Shih, Ie-Ming, Wang, Yue, Zhang, Zhen, ...

Abstract Background Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical methods...

Understanding and Modeling of Aesthetic Response to Shape and Color in Car Body Design (2008)

Wang, Chen

This study explored the phenomenon that a consumer's preference on color of car body may vary depending on shape of the car body. First, the study attempted to establish a theoretical framework that...

DiCAS: An efficient distributed caching mechanism for P2P systems (2008)

Chen Wang, Student Member, Li Xiao, Yunhao Liu, Pei Zheng

Abstract—Peer-to-peer networks are widely criticized for their inefficient flooding search mechanism. Distributed Hash Table (DHT) algorithms have been proposed to improve the search efficiency by...

BioMed Central (2008)

Bmc Bioinformatics, Chen Wang, Jianhua Xuan, Li Chen, Po Zhao, Yue Wang, ...

Proceedings Motif-directed network component analysis for regulatory network inference

Locating Sensors in Obstructed Environments (2008)

Chen Wang, Li Xiao, Rong Jin

Accurately determining physical positions of sensors is an important problem and is essential to many location-aware applications and protocols. Previous approaches for sensor localization can be...

Bipyridine-mediated assembling characteristics of aromatic acid derivatives (2008)

Yang, Yan-Lian, Zhao, Ke-Qing, Zeng, Qing-Dao, Wang, Chen

Binary supramolecular assemblies formed by heterogeneous hydrogen bonds of O center dot center dot center dot H-O and N center dot center dot center dot H-O mediated by 4,4'bipytidine (Bpy) were...

SOR: A Practical System for Ontology Storage, Reasoning and Search (2008)

Jing Lu, Li Ma, Lei Zhang, Jean-sébastien Brunner, Chen Wang, Yue Pan, ...

Ontology, an explicit specification of shared conceptualization, has been increasingly used to define formal data semantics and improve data reusability and interoperability in enterprise information...

Image compression with structure-aware inpainting (2008)

Chen Wang, Xiaoyan Sun, Feng Wu, Hongkai Xiong

Abstract — This paper carves out a way to image compression that is motivated by the recent advancement in image inpainting. An image coding approach is proposed in which a number of regions of the...

An Effective P2P Search Scheme to Exploit File Sharing Heterogeneity (2008)

Chen Wang, Student Member, Li Xiao

Abstract—Although the original intent of the peer-to-peer (P2P) concept is to treat each participant equally, heterogeneity widely exists in deployed P2P networks. Peers are different from each...

A Proactive Method for Content Distribution in a Data Indexed DHT Overlay (2008)

Bassam A. Alqaralleh, Chen Wang, Bing Bing Zhou, Albert Y. Zomaya

Abstract. In a data-indexed DHT overlay network, published data annotations form distributed databases. Queries are distributed to these databases in a nonuniform way. Constructing content...

Organic-inorganic hybrid aligned by the ligand-ligand hydrogen bonds by using pyridyl-substituted oxalamides as the building blocks (2008)

Zeng, Qingdao, Lei, Shengbin, Liu, Caiming, Piao, Lingyu, ...

Pyridyl-substituted oxalamides, L-1 (4-pyCH(2)NHCOCONHCH(2)Py-4), L-2 (3-pyCH(2)NHCOCONHCH(2)PY-3), and L-3 (2-pyCH(2)NHCOCONHCH(2)PY-2), with HgI2 and/or CuBr2, form three new supramolecular...

Motif-directed network component analysis for regulatory network inference (2008)

Wang, Chen, Xuan, Jianhua, Chen, Li, Zhao, Po, Wang, Yue, Clarke, Robert, ...

Abstract Background Network Component Analysis (NCA) has shown its effectiveness in discovering regulators and inferring transcription factor activities (TFAs) when both microarray data and...

WWW 2007 / Track: Semantic Web Session: Applications Explorations in the Use of Semantic Web Technologies for Product Information Management (2008)

Jean-sébastien Brunner, Li Ma, Chen Wang, Lei Zhang, Daniel C. Wolfson, Yue Pan, ...

Master data refers to core business entities a company uses repeatedly across many business processes and systems (such as lists or hierarchies of customers, suppliers, accounts, products, or...

SUDEPHIC: Self-Tuning Density-Based (2008)

Partitioning And Hierarchical, Ding Zhou, Zunping Cheng, Chen Wang, Haofeng Zhou, Wei Wang, ...

Clustering is one of the primary techniques in data mining, for which to find the user expecting result is a major issue. However, to dynamically specify the parameters for clustering algorithms...

Selective degradation of wood lignin over noble-metal catalysts in a two-step process (2008)

Yan, Ning, Zhao, Chen, Dyson, Paul J., Wang, Chen, Liu, Ling-tao, Kou, Yuan

Direct conversion of lignin into alkanes and methanol was carried out in a two-step process (hydrogenolysis and hydrogenation) involving initial treatment of white birch wood sawdust with H2 in...

Selective degradation of wood lignin over noble-metal catalysts in a two-step process (2008)

Yan, Ning, Zhao, Chen, Dyson, Paul J., Wang, Chen, Liu, Ling-tao, Kou, Yuan

Direct conversion of lignin into alkanes and methanol was carried out in a two-step process (hydrogenolysis and hydrogenation) involving initial treatment of white birch wood sawdust with H2 in...

The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast (2008)

Easlon, Erin, Tsang, Felicia, Skinner, Craig, Wang, Chen, Lin, Su-Ju

Recent studies suggest that increased mitochondrial metabolism and the concomitant decrease in NADH levels mediate calorie restriction (CR)-induced life span extension. The mitochondrial inner...

A Framework for Exploiting Object Parallelism in Distributed Systems (2007)

Chen Wang, Yong Meng Teo

Abstract. To support parallel computing in a distributed object-based computing platform, a uniform high performance distributed object architecture layer is necessary. In this paper, we propose a...

Electronically engineered interface molecular superlattices: STM study of aromatic molecules on graphite (2007)

Deng, Ke, Yang, Yan-Lian, Zeng, Qing-Dao, Wang, Chen

We report the observation of the molecular superlattice driven by the site-dependent adsorption of aromatic molecules on graphite surface by using scanning tunneling microscopy. Furthermore,...

Supramolecular architectures of metal-containing macrocycles and a one-dimensional supramolecular structure based on a flexible ligand with an azobenzene group (2007)

Wu, Dongxia CORA, Liu, Caiming, Wang, Chen

Three new supramolecular structures, [(CuCl)(2)L-2](Cl)(2)center dot 3H(2)O (1), [(CuBr)(2)L-2](Br)(2)center dot 3.5H(2)O (2), and L center dot 2HClO(4) (3), have been prepared by ligand L (L =...

Gene Module Identification from Microarray Data Using Nonnegative Independent Component Analysis (2007)

Ting Gong, Jianhua Xuan, Chen Wang, Huai Li, Eric Hoffman, Robert Clarke, ...

Genes mostly interact with each other to form transcriptional modules for performing single or multiple functions. It is important to unravel such transcriptional modules and to determine how...

A Dominating and Absorbent Set in Wireless Ad-hoc Networks with Different Transmission (2007)

Myung Ah Park, James Willson, My T. Thai, Chen Wang, Weili Wu, Andras Farago

Unlike a cellular or wired network, there is no base station or network infrastructure in a wireless ad-hoc network, in which nodes communicate with each other via peer communications. In order to...

Wave Modes in the Magnetospheres of Pulsars and Magnetars (2006)

Wang, Chen, Lai, Dong

We study the wave propagation modes in the relativistic streaming pair plasma of the magnetospheres of pulsars and magnetars, focusing on the effect of vacuum polarization. We show that the combined...

Spin-Kick Correlation in Neutron Stars: Alignment Conditions and Implications (2006)

Wang, Chen, Lai, Dong, Han, JinLin

Recent observations of pulsar wind nebulae and radio polarization profiles revealed a tendency of the alignment between the spin and velocity directions in neutron stars. We study the condition for...

An ankyrin repeat-containing protein, characterized as a ubiquitin ligase, is closely associated with membrane-enclosed organelles and required for pollen germination and pollen tube growth in lily (2006)

Del Casino, Cecilia, Autino, Antonella, Shen, Mouhua, Yuan, Shuai, ...

Exhibiting rapid polarized growth, the pollen tube delivers the male gametes into the ovule for fertilization in higher plants. To get an overall picture of gene expression during pollen germination...

DiCAS : an efficient distributed caching mechanism for P2P systems (2006)

Wang, Chen, Xiao, Li, Liu, Yunhao, Zheng, Pei

Peer-to-peer networks are widely criticized for their inefficient flooding search mechanism. Distributed Hash Table (DHT) algorithms have been proposed to improve the search efficiency by mapping the...

Locating sensors in concave areas (2006)

Chen Wang, Li Xiao

Abstract — In sensor network localization, multihop based approaches were proposed to approximate the shortest paths to Euclidean distances between pairwise sensors. A good approximation can be...

Neutron Star Kicks in Isolated and Binary Pulsars: Observational Constraints and Implications for Kick Mechanisms (2005)

Wang, Chen, Lai, Dong, Han, JinLin

We study observational constraints on neutron star (NS) kicks for isolated pulsars and for neutron stars in binary systems. We are particularly interested in the evidence of kick-spin...

Medical Information Sources for Cancer Patients and Their Companions (2005)

Wang, Chen

Today patients and their companions use various sources to gain knowledge of cancer. The ability to clearly determine their current and future information sources can help both physicians and...

Medical Information Sources for Cancer Patients and Their Companions (2005)

Wang, Chen

Today patients and their companions use various sources to gain knowledge of cancer. The ability to clearly determine their current and future information sources can help both physicians and...

Defect Aware Test Patterns (2005)

Tang, Huaxing, Chen, Gang, Reddy, Sudhakar M., Wang, Chen, Rajski, Janusz, Pomeranz, Irith

A method to generate test patterns referred to as defect aware test patterns is proposed. Defect aware test patterns have greater ability to detect un-modeled defects. The proposed method can be used...

Defect Aware Test Patterns (2005)

Tang, Huaxing, Chen, Gang, Reddy, Sudhakar M., Wang, Chen, Rajski, Janusz, Pomeranz, Irith

A method to generate test patterns referred to as defect aware test patterns is proposed. Defect aware test patterns have greater ability to detect un-modeled defects. The proposed method can be used...

Minimum Coverage Breach and Maximum Network Lifetime in Wireless Sensor Networks", Submitted to (2005)

Yingshu Li, Chen Wang

Abstract—Network lifetime is a critical issue in Wireless Sensor Networks. It is possible to extend network lifetime by organizing the sensors into a number of sensor covers. However, with the...

An Efficient Approach for Power Delivery Network Design with Closed-Form Expressions for Parasitic Interconnect Inductances”, submitted to (2005)

Chen Wang, Jingkun Mao, Shaofeng Luan, Lin Zhang, Jun Fan, David J, ...

Investigation of a DC power delivery network, consisting of a multilayer PCB using area fills for power and return, involves the distributed behavior of the power/ground planes and the parasitics...

Sensor localization in an obstructed environment (2005)

Chen Wang, Li Xiao, Rong Jin

Abstract. Sensor localization can be divided into two categories: rangebased approaches, and rang-free approaches. Although range-based approaches tend to be more accurate than range-free approaches,...

Fault diagnosis in designs with convolutional compactors,” ITC (2004)

Grzegorz Mrugalski, Artur Pogiel, Janusz Rajski, Jerzy Tyszer, Chen Wang

The paper introduces a new non-adaptive fault diagnosis technique for scan-based designs. The proposed scheme guarantees accurate and time-efficient identification of failing scan cells based on...

Scalable mining of large disk-based graph databases (2004)

Chen Wang, Wei Wang, Jian Pei, Yongtai Zhu, Baile Shi

Mining frequent structural patterns from graph databases is an interesting problem with broad applications. Most of the previous studies focus on pruning unfruitful search subspaces effectively, but...

Stock Grants as a Committment Device (2003)

Clementi, Gian Luca, Cooley, Thomas, Wang, Chen

A large and increasing fraction of the value of executives’ compensation is accounted for by security grants. It is often argued that the optimal compensation contracts characterized in the...

Stock Grants as a Committment Device (2003)

Clementi, Gian Luca, Cooley, Thomas, Wang, Chen

A large and increasing fraction of the value of executives’ compensation is accounted for by security grants. It is often argued that the optimal compensation contracts characterized in the...

Delayed minocycline but not delayed mild hypothermia protects against embolic stroke (2002)

Wang, Chen, Yang, Tao, Noor, Raza, Shuaib, Ashfaq

Abstract Background Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study, effects of minocycline, an anti-inflammatory agent, alone or...

Joint modeling quality of life and survival / (2001)

Wang, Chen.

Thesis (Ph. D.)--University of Wisconsin--Madison, 2001.

Joint modeling quality of life and survival / (2001)

Wang, Chen.

Thesis (Ph. D.)--University of Wisconsin--Madison, 2001.

TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales (2001)

Deber, Charles M., Wang, Chen, Liu, Li-Ping, Prior, Andrew S., Agrawal, Shuchi, Muskat, Brenda L., ...

Based on the principle of dual prediction by segment hydrophobicity and nonpolar phase helicity, in concert with imposed threshold values of these two parameters, we developed the automated...

The co... (2000)

Chen Wang, Yong Meng Teo

parallel computing on a distributed object architecture

Formation of [gamma]-lactams and lactones by radical cyclizations, homolytic aromatic alkylations, and preparation of levoglucosenone and its chiral derivatives / (1999)

Wang, Chen.

Radical cyclization methodology has been explored for the formation of functionalized [Gamma]-lactams and [Gamma]-lactones in the addition of PhSO₂Br, under photolysis, to diene amides, or diene...

Modeling multi-attribute utility theory with object-oriented programming / (1994)

Wang, Chen.

Report (M.S.)--Virginia Polytechnic Institute and State University, 1994.

Accumulator-Based Compaction of Test Responses (1993)

Janusz Rajski, Jerzy Tyszer, Chen Wang, Sudhakar M. Reddy

This paper introduces a finite memory compactor called convolutional compactor that provides compaction ratios of test responses in excess of 100x even for a very small number of outputs. This is...

Scanning tunneling microscopy and spectroscopy / (1992)

Wang, Chen.

Thesis (Ph. D.)--University of Virginia, 1992.

Conserved Composition of Mammalian Box H/ACA and Box C/D Small Nucleolar Ribonucleoprotein Particles and Their Interaction with the Common Factor Nopp140

Yang, Yunfeng, Isaac, Cynthia, Wang, Chen, Dragon, François, Pogac̆ić, Vanda, Meier, U. Thomas

Small nucleolar ribonucleoprotein particles (snoRNPs) mainly catalyze the modification of rRNA. The two major classes of snoRNPs, box H/ACA and box C/D, function in the pseudouridylation and...

Initiation of Nucleolar Assembly Is Independent of RNA Polymerase I Transcription

Dousset, Thibaut, Wang, Chen, Verheggen, Céline, Chen, Danyang, Hernandez-Verdun, Danièle, Huang, Sui

This report examines the distribution of an RNA polymerase I transcription factor (upstream binding factor; UBF), pre-rRNA processing factors (nucleolin and fibrillarin), and pre-rRNAs throughout...

Single molecule physics and chemistry

Bai, Chunli, Wang, Chen, Xie, X. Sunney, Wolynes, Peter G.

New experiments using scanning probe microcopies and advanced optical methods allow us to study molecules as individuals, not just as populations. The findings of these studies not only include the...

FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles

Pendergrast, P. Shannon, Wang, Chen, Hernandez, Nouria, Huang, Sui

FBI-1 is a cellular POZ-domain–containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically...

Immunopurified Small Nucleolar Ribonucleoprotein Particles Pseudouridylate rRNA Independently of Their Association with Phosphorylated Nopp140

Wang, Chen, Query, Charles C., Meier, U. Thomas

The isomerization of up to 100 uridines to pseudouridines (Ψs) in eukaryotic rRNA is guided by a similar number of box H/ACA small nucleolar RNAs (snoRNAs), each forming a unique small nucleolar...

RNA Polymerase III Transcripts and the PTB Protein Are Essential for the Integrity of the Perinucleolar Compartment

Wang, Chen, Politz, Joan C., Pederson, Thoru, Huang, Sui

The perinucleolar compartment (PNC) is a nuclear substructure present in transformed cells. The PNC is defined by high concentrations of certain RNA binding proteins and a subset of small RNAs...

Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins

Wang, Chen, Meier, U Thomas

Mammalian H/ACA small nucleolar RNAs and telomerase RNA share common sequence and secondary structure motifs that form ribonucleoprotein particles (RNPs) with the same four core proteins, NAP57 (also...

Development of Genome-Wide DNA Polymorphism Database for Map-Based Cloning of Rice Genes1[w]

Shen, Ying-Jia, Jiang, Hua, Jin, Jian-Peng, Zhang, Zai-Bao, Xi, Biao, He, You-Yu, ...

DNA polymorphism is the basis to develop molecular markers that are widely used in genetic mapping today. A genome-wide rice (Oryza sativa) DNA polymorphism database has been constructed in this work...

Hsp90 Regulates Activation of Interferon Regulatory Factor 3 and TBK-1 Stabilization in Sendai Virus-infected Cells

Yang, Kai, Shi, Hexin, Qi, Rong, Sun, Shaogang, Tang, Yujie, Zhang, Bianhong, ...

Interferon regulatory factor 3 (IRF3) plays a crucial role in mediating cellular responses to virus intrusion. The protein kinase TBK1 is a key regulator inducing phosphorylation of IRF3. The...

Cell Aggregation-induced FGF8 Elevation Is Essential for P19 Cell Neural Differentiation

Wang, Chen, Xia, Caihong, Bian, Wei, Liu, Li, Lin, Wei, Chen, Ye-Guang, ...

FGF8, a member of the fibroblast growth factor (FGF) family, has been shown to play important roles in different developing systems. Mouse embryonic carcinoma P19 cells could be induced by retinoic...

Conserved Composition of Mammalian Box H/ACA and Box C/D Small Nucleolar Ribonucleoprotein Particles and Their Interaction with the Common Factor Nopp140

Yang, Yunfeng, Isaac, Cynthia, Wang, Chen, Dragon, François, Pogac̆ić, Vanda, Meier, U. Thomas

Small nucleolar ribonucleoprotein particles (snoRNPs) mainly catalyze the modification of rRNA. The two major classes of snoRNPs, box H/ACA and box C/D, function in the pseudouridylation and...

Initiation of Nucleolar Assembly Is Independent of RNA Polymerase I Transcription

Dousset, Thibaut, Wang, Chen, Verheggen, Céline, Chen, Danyang, Hernandez-Verdun, Danièle, Huang, Sui

This report examines the distribution of an RNA polymerase I transcription factor (upstream binding factor; UBF), pre-rRNA processing factors (nucleolin and fibrillarin), and pre-rRNAs throughout...

Single molecule physics and chemistry

Bai, Chunli, Wang, Chen, Xie, X. Sunney, Wolynes, Peter G.

New experiments using scanning probe microcopies and advanced optical methods allow us to study molecules as individuals, not just as populations. The findings of these studies not only include the...

FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles

Pendergrast, P. Shannon, Wang, Chen, Hernandez, Nouria, Huang, Sui

FBI-1 is a cellular POZ-domain–containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically...

Immunopurified Small Nucleolar Ribonucleoprotein Particles Pseudouridylate rRNA Independently of Their Association with Phosphorylated Nopp140

Wang, Chen, Query, Charles C., Meier, U. Thomas

The isomerization of up to 100 uridines to pseudouridines (Ψs) in eukaryotic rRNA is guided by a similar number of box H/ACA small nucleolar RNAs (snoRNAs), each forming a unique small nucleolar...

RNA Polymerase III Transcripts and the PTB Protein Are Essential for the Integrity of the Perinucleolar Compartment

Wang, Chen, Politz, Joan C., Pederson, Thoru, Huang, Sui

The perinucleolar compartment (PNC) is a nuclear substructure present in transformed cells. The PNC is defined by high concentrations of certain RNA binding proteins and a subset of small RNAs...

Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins

Wang, Chen, Meier, U Thomas

Mammalian H/ACA small nucleolar RNAs and telomerase RNA share common sequence and secondary structure motifs that form ribonucleoprotein particles (RNPs) with the same four core proteins, NAP57 (also...

Development of Genome-Wide DNA Polymorphism Database for Map-Based Cloning of Rice Genes1[w]

Shen, Ying-Jia, Jiang, Hua, Jin, Jian-Peng, Zhang, Zai-Bao, Xi, Biao, He, You-Yu, ...

DNA polymorphism is the basis to develop molecular markers that are widely used in genetic mapping today. A genome-wide rice (Oryza sativa) DNA polymorphism database has been constructed in this work...

Hsp90 Regulates Activation of Interferon Regulatory Factor 3 and TBK-1 Stabilization in Sendai Virus-infected Cells

Yang, Kai, Shi, Hexin, Qi, Rong, Sun, Shaogang, Tang, Yujie, Zhang, Bianhong, ...

Interferon regulatory factor 3 (IRF3) plays a crucial role in mediating cellular responses to virus intrusion. The protein kinase TBK1 is a key regulator inducing phosphorylation of IRF3. The...

Cell Aggregation-induced FGF8 Elevation Is Essential for P19 Cell Neural Differentiation

Wang, Chen, Xia, Caihong, Bian, Wei, Liu, Li, Lin, Wei, Chen, Ye-Guang, ...

FGF8, a member of the fibroblast growth factor (FGF) family, has been shown to play important roles in different developing systems. Mouse embryonic carcinoma P19 cells could be induced by retinoic...

A Deletion at the Mouse Xist Gene Exposes Trans-effects That Alter the Heterochromatin of the Inactive X Chromosome and the Replication Time and DNA Stability of Both X Chromosomes

Diaz-Perez, Silvia V., Ferguson, David O., Wang, Chen, Csankovszki, Gyorgyi, Wang, Chengming, Tsai, Shih-Chang, ...

The inactive X chromosome of female mammals displays several properties of heterochromatin including late replication, histone H4 hypoacetylation, histone H3 hypomethylation at lysine-4, and...

An Ankyrin Repeat-Containing Protein, Characterized as a Ubiquitin Ligase, Is Closely Associated with Membrane-Enclosed Organelles and Required for Pollen Germination and Pollen Tube Growth in Lily1[W]

Huang, Jian, Chen, Feng, Del Casino, Cecilia, Autino, Antonella, Shen, Mouhua, Yuan, Shuai, ...

Exhibiting rapid polarized growth, the pollen tube delivers the male gametes into the ovule for fertilization in higher plants. To get an overall picture of gene expression during pollen germination...

UXT is a novel and essential cofactor in the NF-κB transcriptional enhanceosome

Sun, Shaogang, Tang, Yujie, Lou, Xiwen, Zhu, Lianhui, Yang, Kai, Zhang, Bianhong, ...

As a latent transcription factor, nuclear factor κB (NF-κB) translocates from the cytoplasm into the nucleus upon stimulation and mediates the expression of genes that are important in immunity,...

Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins

Chen, Danyang, Dundr, Miroslav, Wang, Chen, Leung, Anthony, Lamond, Angus, Misteli, Tom, ...

During mitosis, chromosomes are highly condensed and transcription is silenced globally. One explanation for transcriptional repression is the reduced accessibility of transcription factors. To...

Zinc Finger Protein, Hzf, Is Required for Megakaryocyte Development and Hemostasis

Kimura, Yuki, Hart, Adam, Hirashima, Masanori, Wang, Chen, Holmyard, Doug, Pittman, Jackie, ...

Using an expression gene trapping strategy, we recently identified a novel gene, hematopoietic zinc finger (Hzf), which encodes a protein containing three C2H2-type zinc fingers that is predominantly...

Alteration of nuclear lamin organization inhibits RNA polymerase II–dependent transcription

Spann, Timothy P., Goldman, Anne E., Wang, Chen, Huang, Sui, Goldman, Robert D.

RTegulation of gene activity is mediated by alterations in chromatin organization. In addition, chromatin organization may be governed in part by interactions with structural components of the...

TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales

Deber, Charles M., Wang, Chen, Liu, Li-Ping, Prior, Andrew S., Agrawal, Shuchi, Muskat, Brenda L., ...

Based on the principle of dual prediction by segment hydrophobicity and nonpolar phase helicity, in concert with imposed threshold values of these two parameters, we developed the automated...

The malate–aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast

Easlon, Erin, Tsang, Felicia, Skinner, Craig, Wang, Chen, Lin, Su-Ju

Recent studies suggest that increased mitochondrial metabolism and the concomitant decrease in NADH levels mediate calorie restriction (CR)-induced life span extension. The mitochondrial inner...

Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner*

Wang, Chen, Norton, John T., Ghosh, Supurna, Kim, Julie, Fushimi, Kazuo, Wu, Jane Y., ...

RNA processing is altered during malignant transformation, and expression of the polypyrimidine tract-binding protein (PTB) is often increased in cancer cells. Although some data support that PTB...

Gene Module Identification from Microarray Data Using Nonnegative Independent Component Analysis

Gong, Ting, Xuan, Jianhua, Wang, Chen, Li, Huai, Hoffman, Eric, Clarke, Robert, ...

Genes mostly interact with each other to form transcriptional modules for performing single or multiple functions. It is important to unravel such transcriptional modules and to determine how...