Rabinowitz, Joseph E., Rolling, Fabienne, Li, Chengwen, Conrath, Hervè, Xiao, Weidong, Xiao, Xiao, ...
The serotypes of adeno-associated virus (AAV) have the potential to become important resources for clinical gene therapy. In an effort to compare the role of serotype-specific virion shells on vector...
Adeno-associated virus vectors: potential applications for cancer gene therapy
Li, Chengwen, Bowles, Dawn E, Van Dyke, Terry, Samulski, Richard Jude
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success in animal models. The primary hurdle of fully exploiting the arsenal of molecular targets and...
Li, Chengwen, Samulski, R. Jude
One of the major limitations of the use of adeno-associated virus (AAV) as a tool for gene therapy is the difficulty in providing sufficient quantities of the virus for pre-clinical and clinical...
Rabinowitz, Joseph E., Rolling, Fabienne, Li, Chengwen, Conrath, Hervè, Xiao, Weidong, Xiao, Xiao, ...
The serotypes of adeno-associated virus (AAV) have the potential to become important resources for clinical gene therapy. In an effort to compare the role of serotype-specific virion shells on vector...
Li, Chengwen, Hirsch, Matthew, Asokan, Aravind, Zeithaml, Brian, Ma, Hong, Kafri, Tal, ...
A recent clinical trial has suggested that recombinant adeno-associated virus (rAAV) vector transduction in humans induces a cytotoxic T-lymphocyte (CTL) response against the AAV2 capsid. To directly...
Reducing the Risk of Adeno-Associated Virus (AAV) Vector Mobilization with AAV Type 5 Vectors▿
Hewitt, F. Curtis, Li, Chengwen, Gray, Steven J., Cockrell, Shelley, Washburn, Michael, Samulski, R. Jude
Current adeno-associated virus (AAV) gene therapy vectors package a transgene flanked by the terminal repeats (TRs) of AAV type 2 (AAV2). Although these vectors are replication deficient, wild-type...
AAV Recombineering with Single Strand Oligonucleotides
Hirsch, Matthew L., Storici, Francesca, Li, Chengwen, Choi, Vivian W., Samulski, R. Jude
Adeno-associated virus (AAV) transduction initiates a signaling cascade that culminates in a transient DNA damage response. During this time, host DNA repair proteins convert the linear single-strand...