Dynamic and Heterogeneous Mutations to Fluconazole Resistance in Cryptococcus neoformans
Xu, Jianping, Onyewu, Chiatogu, Yoell, Heather J., Ali, Rabia Y., Vilgalys, Rytas J., Mitchell, Thomas G.
Infections with the human pathogenic basidiomycetous yeast Cryptococcus neoformans are often treated with fluconazole. Resistance to this antifungal agent has been reported. This study investigated...
Onyewu, Chiatogu, Blankenship, Jill R., Del Poeta, Maurizio, Heitman, Joseph
Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity,...
In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus
Steinbach, William J., Schell, Wiley A., Blankenship, Jill R., Onyewu, Chiatogu, Heitman, Joseph, Perfect, John R.
The optimal treatment for invasive aspergillosis remains elusive, despite the increased efficacy of newer agents. The immunosuppressants cyclosporine (CY), tacrolimus (FK506), and sirolimus (formerly...
Onyewu, Chiatogu, Wormley, Floyd L., Perfect, John R., Heitman, Joseph
In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces...
Dynamic and Heterogeneous Mutations to Fluconazole Resistance in Cryptococcus neoformans
Xu, Jianping, Onyewu, Chiatogu, Yoell, Heather J., Ali, Rabia Y., Vilgalys, Rytas J., Mitchell, Thomas G.
Infections with the human pathogenic basidiomycetous yeast Cryptococcus neoformans are often treated with fluconazole. Resistance to this antifungal agent has been reported. This study investigated...
Onyewu, Chiatogu, Blankenship, Jill R., Del Poeta, Maurizio, Heitman, Joseph
Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity,...
In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus
Steinbach, William J., Schell, Wiley A., Blankenship, Jill R., Onyewu, Chiatogu, Heitman, Joseph, Perfect, John R.
The optimal treatment for invasive aspergillosis remains elusive, despite the increased efficacy of newer agents. The immunosuppressants cyclosporine (CY), tacrolimus (FK506), and sirolimus (formerly...
Onyewu, Chiatogu, Wormley, Floyd L., Perfect, John R., Heitman, Joseph
In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces...
Onyewu, Chiatogu, Afshari, Natalie A., Heitman, Joseph
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively...
Onyewu, Chiatogu, Eads, Emily, Schell, Wiley A., Perfect, John R., Ullmann, Yehuda, Kaufman, Gil, ...
Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning...