Chien-Hsiung Pan

Screening of Protective Antigens of Japanese Encephalitis Virus by DNA Immunization: a Comparative Study with Conventional Viral Vaccines

Chen, Hsin-Wei, Pan, Chien-Hsiung, Liau, Ming-Yi, Jou, Ruwen, Tsai, Chiao-Jung, Wu, Hsin-Jung, ...

In this study, we evaluated the relative role of the structural and nonstructural proteins of the Japanese encephalitis virus (JEV) in inducing protective immunities and compared the results with...

Protective Mechanisms Induced by a Japanese Encephalitis Virus DNA Vaccine: Requirement for Antibody but Not CD8+ Cytotoxic T-Cell Responses

Pan, Chien-Hsiung, Chen, Hsin-Wei, Huang, Hui-Wen, Tao, Mi-Hua

We have previously shown that a plasmid (pE) encoding the Japanese encephalitis virus (JEV) envelope (E) protein conferred a high level of protection against a lethal viral challenge. In the present...

Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles

Pan, Chien-Hsiung, Valsamakis, Alexandra, Colella, Teresa, Nair, Nitya, Adams, Robert J., Polack, Fernando P., ...

Measles remains a major worldwide problem partly because of difficulties with vaccination of young infants. New vaccine strategies need to be safe and to provide sustained protective immunity. We...

Screening of Protective Antigens of Japanese Encephalitis Virus by DNA Immunization: a Comparative Study with Conventional Viral Vaccines

Chen, Hsin-Wei, Pan, Chien-Hsiung, Liau, Ming-Yi, Jou, Ruwen, Tsai, Chiao-Jung, Wu, Hsin-Jung, ...

In this study, we evaluated the relative role of the structural and nonstructural proteins of the Japanese encephalitis virus (JEV) in inducing protective immunities and compared the results with...

Protective Mechanisms Induced by a Japanese Encephalitis Virus DNA Vaccine: Requirement for Antibody but Not CD8+ Cytotoxic T-Cell Responses

Pan, Chien-Hsiung, Chen, Hsin-Wei, Huang, Hui-Wen, Tao, Mi-Hua

We have previously shown that a plasmid (pE) encoding the Japanese encephalitis virus (JEV) envelope (E) protein conferred a high level of protection against a lethal viral challenge. In the present...

Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles

Pan, Chien-Hsiung, Valsamakis, Alexandra, Colella, Teresa, Nair, Nitya, Adams, Robert J., Polack, Fernando P., ...

Measles remains a major worldwide problem partly because of difficulties with vaccination of young infants. New vaccine strategies need to be safe and to provide sustained protective immunity. We...

C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression▿

Melendi, Guillermina A., Hoffman, Scott J., Karron, Ruth A., Irusta, Pablo M., Laham, Federico R., Humbles, Alison, ...

Enhanced respiratory syncytial virus disease, a serious pulmonary disorder that affected recipients of an inactivated vaccine against respiratory syncytial virus in the 1960s, has delayed the...

Dose-Dependent Protection against or Exacerbation of Disease by a Polylactide Glycolide Microparticle-Adsorbed, Alphavirus-Based Measles Virus DNA Vaccine in Rhesus Macaques▿

Pan, Chien-Hsiung, Nair, Nitya, Adams, Robert J., Zink, M. Christine, Lee, Eun-Young, Polack, Fernando P., ...

Measles remains an important cause of vaccine-preventable child mortality. Development of a low-cost, heat-stable vaccine for infants under the age of 6 months could improve measles control by...

Use of Vaxfectin Adjuvant with DNA Vaccine Encoding the Measles Virus Hemagglutinin and Fusion Proteins Protects Juvenile and Infant Rhesus Macaques against Measles Virus▿

Pan, Chien-Hsiung, Jimenez, Gretchen S., Nair, Nitya, Wei, Qun, Adams, Robert J., Polack, Fernando P., ...

A measles virus vaccine for infants under 6 months of age would help control measles. DNA vaccines hold promise, but none has provided full protection from challenge. Codon-optimized plasmid DNAs...