Nina Offenhäuser, Daniela Castelletti, Lisa Mapelli, Cristina Regondi, Paola Rossi, Carolina Frassoni, ...
ethanol required to induce the loss of righting reflex was determined using the “up
Nina Offenhäuser, Daniela Castelletti, Lisa Mapelli, Maria Cristina Regondi, Paola Rossi, Carolina Frassoni, ...
Dynamic modulation of the actin cytoskeleton is critical for synaptic plasticity, abnormalities of which are thought to contribute to mental illness and addiction. Here we report that mice lacking...
Role of platelet-derived growth factors in physiology and medicine (2008)
Andrae, Johanna, Gallini, Radiosa, Betsholtz, Christer
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and...
Pericytes limit tumor cell metastasis. (2006)
Xian, Xiaojie, Hakansson, Joakim, Stahlberg, Anders, Lindblom, Per, Betsholtz, Christer, Gerhardt, Holger, ...
Abstract is not available
Nyström, Henrik C., Lindblom, Per, Wickman, Anna, Andersson, Irene, Norlin, Jenny, Fäldt, Jenny, ...
Objective: Extracellular retention of PDGF-B has been proposed to play an important role in PDGF-B signalling. We used the PDGF-B retention motif knockout mouse (RetKO) to study the effects of...
Reichenbach, Andreas, Betsholtz, Christer, Wolburg, Hartwig, Pekny, Milos
In epithelial and muscle cells, intermediate filaments (IFs) are important for resistance to mechanical stress. The aim of this study was to elucidate whether IFs are also important for providing...
Sabrina Basciani, Stefania Mariani, Mario Arizzi, Marina Brama, Andrea Ricci, Christer Betsholtz, ...
The platelet-derived growth factor (PDGF) family of ligands and receptors play a pivotal role in the development of various organs. The critical importance of the PDGF-mediated signaling during...
Haigh,Jody J, Morelli,Paula I, Gerhardt,Holger, Haigh,Katharina, Tsien,John, Damert,Annette, ...
To determine the function of VEGF-A in nervous system development, we have utilized the Nestin promoter-driven Cre recombinase transgene, in conjunction with a conditional and hypomorphic VEGF-A...
Haigh, Jody J, Morelli, Paula I, Gerhardt, Holger, Haigh, Katharina, Tsien, John, Damert, Annette, ...
To determine the function of VEGF-A in nervous system development, we have utilized the Nestin promoter-driven Cre recombinase transgene, in conjunction with a conditional and hypomorphic VEGF-A...
Lindblom, Per, Gerhardt, Holger, Liebner, Stefan, Abramsson, Alexandra, Enge, Maria, Hellström, Mats, ...
Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the...
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. (2002)
Enge, Maria, Bjarnegård, Mattias, Gerhardt, Holger, Gustafsson, Erika, Kalén, Mattias, Asker, Noomi, ...
Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to...
Ruhrberg, Christiana, Gerhardt, Holger, Golding, Matthew, Watson, Rose, Ioannidou, Sofia, Fujisawa, Hajime, ...
Kulkarnl, Prabha S., Sundqvist, Kristina, Betsholtz, Christer, Höglund, Petter, Wiman, Klas G., Zhivotovsky, Boris, ...
Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans...
Role of platelet-derived growth factor in neoplastic transformation /--by Christer Betsholtz. (1986)
Thesis (doctoral)--Uppsala University, 1986.
Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, ...
Caffeine is believed to act by blocking adenosine A1 and A2A receptors (A1R, A2AR), indicating that some A1 receptors are tonically activated. We generated mice with a targeted disruption of the...
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
Enge, Maria, Bjarnegård, Mattias, Gerhardt, Holger, Gustafsson, Erika, Kalén, Mattias, Asker, Noomi, ...
Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to...
Ruhrberg, Christiana, Gerhardt, Holger, Golding, Matthew, Watson, Rose, Ioannidou, Sofia, Fujisawa, Hajime, ...
Branching morphogenesis in the mammalian lung and Drosophila trachea relies on the precise localization of secreted modulators of epithelial growth to select branch sites and direct branch...
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
Lindblom, Per, Gerhardt, Holger, Liebner, Stefan, Abramsson, Alexandra, Enge, Maria, Hellström, Mats, ...
Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the...
Abramsson, Alexandra, Lindblom, Per, Betsholtz, Christer
Tumor-infiltrating blood vessels deviate morphologically and biochemically from normal vessels, raising the prospect of selective pharmacological targeting. Current antiangiogenic approaches focus...
Cytokine detection by antibody-based proximity ligation
Gullberg, Mats, Gústafsdóttir, Sigrún M., Schallmeiner, Edith, Jarvius, Jonas, Bjarnegård, Mattias, Betsholtz, Christer, ...
Efficient and precise detection techniques, along with extensive repertoires of specific binding reagents, will be needed to meet the challenges of proteome analyses. The recently established...
Pericytes limit tumor cell metastasis
Xian, Xiaojie, Håkansson, Joakim, Ståhlberg, Anders, Lindblom, Per, Betsholtz, Christer, Gerhardt, Holger, ...
Previously we observed that neural cell adhesion molecule (NCAM) deficiency in β tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient β...
Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, ...
Caffeine is believed to act by blocking adenosine A1 and A2A receptors (A1R, A2AR), indicating that some A1 receptors are tonically activated. We generated mice with a targeted disruption of the...
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
Enge, Maria, Bjarnegård, Mattias, Gerhardt, Holger, Gustafsson, Erika, Kalén, Mattias, Asker, Noomi, ...
Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to...
Ruhrberg, Christiana, Gerhardt, Holger, Golding, Matthew, Watson, Rose, Ioannidou, Sofia, Fujisawa, Hajime, ...
Branching morphogenesis in the mammalian lung and Drosophila trachea relies on the precise localization of secreted modulators of epithelial growth to select branch sites and direct branch...
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
Lindblom, Per, Gerhardt, Holger, Liebner, Stefan, Abramsson, Alexandra, Enge, Maria, Hellström, Mats, ...
Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the...
Abramsson, Alexandra, Lindblom, Per, Betsholtz, Christer
Tumor-infiltrating blood vessels deviate morphologically and biochemically from normal vessels, raising the prospect of selective pharmacological targeting. Current antiangiogenic approaches focus...
Cytokine detection by antibody-based proximity ligation
Gullberg, Mats, Gústafsdóttir, Sigrún M., Schallmeiner, Edith, Jarvius, Jonas, Bjarnegård, Mattias, Betsholtz, Christer, ...
Efficient and precise detection techniques, along with extensive repertoires of specific binding reagents, will be needed to meet the challenges of proteome analyses. The recently established...
Pericytes limit tumor cell metastasis
Xian, Xiaojie, Håkansson, Joakim, Ståhlberg, Anders, Lindblom, Per, Betsholtz, Christer, Gerhardt, Holger, ...
Previously we observed that neural cell adhesion molecule (NCAM) deficiency in β tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient β...
Large-scale identification of genes implicated in kidney glomerulus development and function
Takemoto, Minoru, He, Liqun, Norlin, Jenny, Patrakka, Jaakko, Xiao, Zhijie, Petrova, Tatiana, ...
To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large-scale sequenced cDNA libraries from mouse glomeruli at different stages of...
Tang, Jingjing, Kozaki, Koichi, Farr, Andrew G., Martin, Paul J., Lindahl, Per, Betsholtz, Christer, ...
Both innate and adaptive immunity contribute to the progression of inflammatory-fibrotic lesions of atherosclerosis. Although platelet-derived growth factor (PDGF)-B has been investigated as a...
Buetow, Bernard S., Crosby, Jeffrey R., Kaminski, Wolfgang E., Ramachandran, Ravi K., Lindahl, Per, Martin, Paul, ...
The hypothesis that wound repair is augmented by delivery of platelet-derived growth factor (PDGF) from platelets and macrophages is an attractive extrapolation from the known activities of PDGF in...
A New Method for Large Scale Isolation of Kidney Glomeruli from Mice
Takemoto, Minoru, Asker, Noomi, Gerhardt, Holger, Lundkvist, Andrea, Johansson, Bengt R., Saito, Yasushi, ...
Here we report a new isolation method for mouse glomeruli. The method is fast and simple and allows for the isolation of virtually all glomeruli present in the adult mouse kidney with minimal...
Kozaki, Koichi, Kaminski, Wolfgang E., Tang, Jingjing, Hollenbach, Stan, Lindahl, Per, Sullivan, Carol, ...
Platelet-derived growth factor (PDGF) is a potent stimulant of smooth muscle cell migration and proliferation in culture. To test the role of PDGF in the accumulation of smooth muscle cells in vivo,...
Bondjers, Cecilia, Kalén, Mattias, Hellström, Mats, Scheidl, Stefan J., Abramsson, Alexandra, Renner, Oliver, ...
All blood capillaries consist of endothelial tubes surrounded by mural cells referred to as pericytes. The origin, recruitment, and function of the pericytes is poorly understood, but the importance...
Abramsson, Alexandra, Kurup, Sindhulakshmi, Busse, Marta, Yamada, Shuhei, Lindblom, Per, Schallmeiner, Edith, ...
During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB...
Johansen, Finn-Eirik, Pekna, Marcela, Norderhaug, Inger Natvig, Haneberg, Bjørn, Hietala, Max Albert, Krajci, Peter, ...
Mucosal surfaces are protected specifically by secretory immunoglobulin A (SIgA) and SIgM generated through external translocation of locally produced dimeric IgA and pentameric IgM. Their active...
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, Holger, Golding, Matthew, Fruttiger, Marcus, Ruhrberg, Christiana, Lundkvist, Andrea, Abramsson, Alexandra, ...
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. It controls several processes in endothelial cells, such as proliferation, survival, and...
Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice
Gnessi, Lucio, Basciani, Sabrina, Mariani, Stefania, Arizzi, Mario, Spera, Giovanni, Wang, Chiayeng, ...
Platelet-derived growth factor (PDGF)- A–deficient male mice were found to develop progressive reduction of testicular size, Leydig cells loss, and spermatogenic arrest. In normal mice, the PDGF-A...
Pekny, Milos, Johansson, Clas B., Eliasson, Camilla, Stakeberg, Josefina, Wallén, Åsa, Perlmann, Thomas, ...
In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin,...
Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis
Hellström, Mats, Gerhardt, Holger, Kalén, Mattias, Li, Xuri, Eriksson, Ulf, Wolburg, Hartwig, ...
The association of pericytes (PCs) to newly formed blood vessels has been suggested to regulate endothelial cell (EC) proliferation, survival, migration, differentiation, and vascular branching....
Generation and Characterization of rgs5 Mutant Mice▿
Nisancioglu, Maya H., Mahoney, William M., Kimmel, Dara D., Schwartz, Stephen M., Betsholtz, Christer, Genové, Guillem
Regulators of G-protein signaling (RGS) are involved in a wide variety of functions, including olfaction, vision, and cell migration. RGS5 has a perivascular expression pattern and was recently...
The Glomerular Transcriptome and a Predicted Protein–Protein Interaction Network
He, Liqun, Sun, Ying, Takemoto, Minoru, Norlin, Jenny, Tryggvason, Karl, Samuelsson, Tore, ...
To increase our understanding of the molecular composition of the kidney glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five...
Role of platelet-derived growth factors in physiology and medicine
Andrae, Johanna, Gallini, Radiosa, Betsholtz, Christer
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and...