A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke (2009)
Gudbjartsson, Daniel F, Holm, Hilma, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Walters, G Bragi, Thorgeirsson, Gudmundur, ...
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. (2009)
Gudbjartsson, Daniel F, Holm, Hilma, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Walters, G Bragi, Thorgeirsson, Gudmundur, ...
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Human gene expression sensitivity according to large scale meta-analysis (2009)
Hao, Pei, Zheng, Siyuan, Ping, Jie, Tu, Kang, Gieger, Christian, Wang-Sattler, Rui, ...
Abstract Background Genes show different sensitivities in expression corresponding to various biological conditions. Systematical study of this concept is required because of its important...
Org, Elin, Eyheramendy, Susana, Juhanson, Peeter, Gieger, Christian, Lichtner, Peter, Klopp, Norman, ...
Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable,...
Ludwig Fahrmeir, Christian Gieger, Christian Heumann
This paper discusses marginal regression for repeated ordinal measurements that are isotonic over time. Such data are often observed in longitudinal studies on healing processes where, due to...
Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke. (2008)
Gretarsdottir, Solveig, Thorleifsson, Gudmar, Manolescu, Andrei, Styrkarsdottir, Unnur, Helgadottir, Anna, Gschwendtner, Andreas, ...
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Common variants near MC4R are associated with fat mass, weight and risk of obesity (2008)
Loos, Ruth J.F., Lindgren, Cecilia M., Li, Shengxu, Wheeler, Eleanor, Zhao, Jing Hua, Prokopenko, Inga, ...
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the...
Gibson, Jane, Tapper, William, Cox, David, Zhang, Weihua, Pfeufer, Arne, Gieger, Christian, ...
Two case/control studies with different phenotypes, marker densities, and microarrays were examined for the most significant single markers in defined regions. They show a pronounced bias toward...
Marginal Regression Models with Varying Coefficients for Correlated Ordinal Data (2007)
This paper discusses marginal regression models for repeated or clustered ordinal measurements in which the coecients of explanatory variables are allowed to vary as smooth functions of other...
Koch, Werner, Hoppmann, Petra, Michou, Elena, Jung, Vanessa, Pfeufer, Arne, Mueller, Jakob C., ...
Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-α, the product of the LTA gene, have been...
Akyol, Mahmut, Jalilzadeh, Shapour, Sinner, Moritz F., Perz, Siegfried, Beckmann, Britt M., Gieger, Christian, ...
Aims The QT interval in the general population is a complex trait with 30–50% heritability. QT prolongation is associated with an increased risk of sudden death. A recent family-based study found...
Marginal Regression Models with Varying Coefficients for Correlated Ordinal Data (1999)
This paper discusses marginal regression models for repeated or clustered ordinal measurements in which the coefficients of explanatory variables are allowed to vary as smooth functions of other...
An Application of Isotonic Longitudinal Marginal Regression to Monitoring the Healing Process (1999)
Ludwig Fahrmeir, Christian Gieger, Christian Heumann
This paper discusses marginal regression for repeated ordinal measurements that are isotonic over time. Such data are often observed in longitudinal studies on healing processes where, due to...
Marginale Regressionsmodelle mit variierenden Koeffizienten für kategoriale Zielvariablen / (1998)
Zugl.: München, Univ., Diss., 1998.
Non- and semiparametric marginal regression models for ordinal response (1997)
We present a class of multivariate regression models for ordinal response variables in which the coefficients of the explanatory variables are allowed to vary as smooth functions of other variables....
An application of isotonic longitudinal marginal regression to monitoring the healing process (1997)
Fahrmeir, Ludwig, Gieger, Christian, Heumann, Christian
This paper discusses marginal regression for repeated ordinal measurements that are isotonic over time. Such data are often observed in longitudinal studies on healing processes where, due to...
Non- and Semiparametric Marginal Regression Models for Ordinal Response (1997)
this paper, we focus attention on cumulative regression models for ordinal responses (McCullagh, 1980) and multivariate extensions. Such models exploit, in a parsimonious way, the ordered scale of...
Additive, Dynamic and Multiplicative Regression (1995)
Fahrmeir, Ludwig, Gieger, Christian, Klinger, Artur
We survey and compare model-based approaches to regression for cross-sectional and longitudinal data which extend the classical parametric linear model for Gaussian responses in several aspects and...
Additive, Dynamic and Multiplicative Regression (1995)
Ludwig Fahrmeir, Christian Gieger, Artur Klinger
this paper we will focus on penalized least squares and likelihood methods as a unifying modelling and estimation approach. From this point of view, the smooth functions f j () are unknown, but...
Gibson, Jane, Tapper, William, Cox, David, Zhang, Weihua, Pfeufer, Arne, Gieger, Christian, ...
Two case/control studies with different phenotypes, marker densities, and microarrays were examined for the most significant single markers in defined regions. They show a pronounced bias toward...
Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, ...
Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus
Weidinger, Stephan, Gieger, Christian, Rodriguez, Elke, Baurecht, Hansjörg, Mempel, Martin, Klopp, Norman, ...
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial...
Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
Gieger, Christian, Geistlinger, Ludwig, Altmaier, Elisabeth, Hrabé De Angelis, Martin, Kronenberg, Florian, Meitinger, Thomas, ...
The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the...
Wang-Sattler, Rui, Yu, Yao, Mittelstrass, Kirstin, Lattka, Eva, Altmaier, Elisabeth, Gieger, Christian, ...
Exposure to nicotine during smoking causes a multitude of metabolic changes that are poorly understood. We quantified and analyzed 198 metabolites in 283 serum samples from the human cohort KORA...
Human gene expression sensitivity according to large scale meta-analysis
Hao, Pei, Zheng, Siyuan, Ping, Jie, Tu, Kang, Gieger, Christian, Wang-Sattler, Rui, ...
Linsel-Nitschke, Patrick, Götz, Anika, Erdmann, Jeanette, Braenne, Ingrid, Braund, Peter, Hengstenberg, Christian, ...
Luca, Diana, Ringquist, Steven, Klei, Lambertus, Lee, Ann B., Gieger, Christian, Wichmann, H.-Erich, ...
Resources being amassed for genome-wide association (GWA) studies include “control databases” genotyped with a large-scale SNP array. How to use these databases effectively is an open question....
Kolz, Melanie, Johnson, Toby, Sanna, Serena, Teumer, Alexander, Vitart, Veronique, Perola, Markus, ...
Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis...
Org, Elin, Eyheramendy, Susana, Juhanson, Peeter, Gieger, Christian, Lichtner, Peter, Klopp, Norman, ...
Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable,...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...
Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array
Sõber, Siim, Org, Elin, Kepp, Katrin, Juhanson, Peeter, Eyheramendy, Susana, Gieger, Christian, ...
The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans. We used...
A Genome-wide Association Study Identifies Three Loci Associated with Mean Platelet Volume
Meisinger, Christa, Prokisch, Holger, Gieger, Christian, Soranzo, Nicole, Mehta, Divya, Rosskopf, Dieter, ...
Mean platelet volume (MPV) is increased in myocardial and cerebral infarction and is an independent and strong predictor for postevent morbidity and mortality. We conducted a genome-wide association...