Rigby, Mark R., Trexler, Alison M., Pearson, Thomas C., Larsen, Christian P.
OBJECTIVE: Blocking T-cell signaling is an effective means to prevent autoimmunity and allograft rejection in many animal models, yet the clinical translation of many of these approaches has not...
Kemball, Christopher C., Lee, Eun D. Han, Szomolanyi-Tsuda, Eva, Pearson, Thomas A., Larsen, Christian P., Lukacher, Aron E.
The requirement for costimulation in antiviral CD8+ T cell responses has been actively investigated for acutely resolved viral infections, but it is less defined for CD8+ T cell responses to...
Induction of operational tolerance to discordant dopaminergic porcine xenografts. (2003)
Larsson, Lena C, Corbascio, Matthias, Pearson, Thomas C, Larsen, Christian P, Ekberg, Henrik, Widner, Håkan
Abstract is not available
Malm, Helene, Corbascio, Matthias, Osterholm, Cecilia, Cowan, Shannon, Larsen, Christian P, Pearson, Thomas C, ...
BACKGROUND: It was recently shown that some strains of mice are capable of rejecting transplants independently of B7 and CD40L signaling and that this rejection is mediated by CD8(+) T cells. LFA-1...
Larsson, Lena C, Corbascio, Matthias, Widner, Håkan, Pearson, Thomas C, Larsen, Christian P, Ekberg, Henrik
Transplantation of embryonic human neural tissue can restore dopamine neurotransmission and improve neurological function in patients with Parkinson's disease. Logistical and ethical factors limit...
Corbascio, Matthias, Mahanty, Harish, Osterholm, Cecilia, Qi, Zhongquan, Pearson, Thomas C, Larsen, Christian P, ...
BACKGROUND: Blockade of CD40 ligand (CD40L; CD154, gp39) is a potential treatment for autoimmune disease and allograft rejection. However, CD40L-/- mice are capable of mobilizing cellular immune...
CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely. (2002)
Corbascio, Matthias, Ekstrand, Helene, Osterholm, Cecilia, Qi, Zhongquan, Simanaitis, Mecislovas, Larsen, Christian P, ...
CTLA4Ig and anti-LFA-1 are members of a new generation of immunomodulatory drugs which inhibit important signaling pathways in T cell activation. Both substances target molecules which have pivitol...
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...
Intravital microscopy identifies selectins that regulate T cell traffic into allografts
Jones, Thomas R., Shirasugi, Nozomu, Adams, Andrew B., Pearson, Thomas C., Larsen, Christian P.
T cell homing to sites of injury and inflammation is a critical step for adaptive immune responses. While much has been learned regarding T cell homing to lymphoid tissues, few studies have directly...
Garber, David A., Silvestri, Guido, Barry, Ashley P., Fedanov, Andrew, Kozyr, Natalia, McClure, Harold, ...
In vivo blockade of CD28 and CD40 T cell costimulation pathways during acute simian immunodeficiency virus (SIV) infection of rhesus macaques was performed to assess the relative contributions of...
Trambley, Joel, Bingaman, Adam W., Lin, Angello, Elwood, Eric T., Waitze, Seung-Yeun, Ha, Jongwon, ...
Simultaneous blockade of the CD40 and CD28 costimulatory pathways is an effective treatment strategy to promote allograft acceptance but does not lead to indefinite allograft survival. The immune...
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...
Intravital microscopy identifies selectins that regulate T cell traffic into allografts
Jones, Thomas R., Shirasugi, Nozomu, Adams, Andrew B., Pearson, Thomas C., Larsen, Christian P.
T cell homing to sites of injury and inflammation is a critical step for adaptive immune responses. While much has been learned regarding T cell homing to lymphoid tissues, few studies have directly...
Garber, David A., Silvestri, Guido, Barry, Ashley P., Fedanov, Andrew, Kozyr, Natalia, McClure, Harold, ...
In vivo blockade of CD28 and CD40 T cell costimulation pathways during acute simian immunodeficiency virus (SIV) infection of rhesus macaques was performed to assess the relative contributions of...
Trambley, Joel, Bingaman, Adam W., Lin, Angello, Elwood, Eric T., Waitze, Seung-Yeun, Ha, Jongwon, ...
Simultaneous blockade of the CD40 and CD28 costimulatory pathways is an effective treatment strategy to promote allograft acceptance but does not lead to indefinite allograft survival. The immune...
Arbiser, Jack L., Bingaman, Adam, Durham, Megan, Cowan, Shannon, Cohen, Cynthia, Zarnegar, Elham, ...
PURPOSE: We wished to determine whether virally- induced endothelial tumors are rejected by CD4 and CD8 lymphocytes, and whether there are differences in requirements for costimulation in the...
Vezys, Vaiva, Masopust, David, Kemball, Christopher C., Barber, Daniel L., O'Mara, Leigh A., Larsen, Christian P., ...
Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and...
Ford, Mandy L., Koehn, Brent H., Wagener, Maylene E., Jiang, Wanhong, Gangappa, Shivaprakash, Pearson, Thomas C., ...
After a brief period of antigenic stimulation, T cells become committed to a program of autonomous expansion and differentiation. We investigated the role of antigen-specific T cell precursor...
Mueller, Scott N., Matloubian, Mehrdad, Clemens, Daniel M., Sharpe, Arlene H., Freeman, Gordon J., Gangappa, Shivaprakash, ...
Many chronic viral infections are marked by pathogen persistence and a generalized immunosuppression. The exact mechanisms by which this occurs are still unknown. Using a mouse model of persistent...
Shuford, Walter W., Klussman, Kerry, Tritchler, Douglas D., Loo, Deryk T., Chalupny, Jan, Siadak, Anthony W., ...
The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4+ and CD8+ T cells after...
Role of CD28 in fatal autoimmune disorder in scurfy mice
Singh, Nagendra, Chandler, Phillip R., Seki, Yoichi, Baban, Babak, Takezaki, Mayuko, Kahler, David J., ...
Scurfy mice develop CD4 T-cell–mediated lymphoproliferative disease leading to death within 4 weeks of age. The scurfy mutation causes loss of function of the foxp3 gene (foxp3sf), which is...
Rigby, Mark R., Trexler, Alison M., Pearson, Thomas C., Larsen, Christian P.
OBJECTIVE—Blocking T-cell signaling is an effective means to prevent autoimmunity and allograft rejection in many animal models, yet the clinical translation of many of these approaches has not...