Christian Winkler

Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration (2009)

Carlsson, Thomas, Carta, Manolo, Muñoz, Ana, Mattsson, Bengt, Winkler, Christian, Kirik, Deniz, ...

Previous studies have shown that serotonin neurons play an important role in the induction and maintenance of l-DOPA-induced dyskinesia in animals with lesion of the nigrostriatal dopamine system....

Biochemische und molekulare Charakterisierung der pflanzlichen TP-abhängigen Phosphofruktokinase aus Spinacia oleracea. (2007)

Winkler, Christian

Obwohl ATP-PFK eines der bedeutensten Enzyme im pflanzlichen Stoffwechsel ist, sind bisher keine Sequenzdaten für dieses Enzym (ATP-PFK; EC 2.7.1.11) in Genbanken zugänglich. In dieser Arbeit wurde...

Bestandsentwicklung des Laubfrosches (Hyla arborea) auf dem Hof Ritzerau während der Betriebsumstellung auf ökologischen Landbau (2007)

Winkler, Christian, Neumann, Helge

The population dynamics of the Common Tree Frog (Hyla arborea) during conversion to organic farming was surveyed on an arable farm in northern Germany. The conver-sion had no notable effects on the...

Bestandsentwicklung des Laubfrosches (Hyla arborea) auf dem Hof Ritzerau während der Betriebsumstellung auf ökologischen Landbau (2007)

Winkler, Christian, Neumann, Helge

The population dynamics of the Common Tree Frog (Hyla arborea) during conversion to organic farming was surveyed on an arable farm in northern Germany. The conver-sion had no notable effects on the...

Simulated microgravity upregulates gene expression of the skeletal regulator core binding factor α1/Runx2 in Medaka fish larvae in vivo (2006)

Renn, Joerg, Seibt, Dieter, Goerlich, Roland, Schartl, Manfred, Winkler, Christian

Long-term space flight results in significant bone loss in humans. However, it remains to be shown how microgravity affects the expression of genes involved in modeling and remodeling of bone...

Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors (2005)

Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Cenci, Angela, ...

Dyskinesias are a major complication of long-term l-3,4-dihydroxyphenylalanine (l-DOPA) treatment in Parkinson's disease, and are believed to result from the intermittent and pulsatile supply of...

Toward a restorative therapy for Parkinson´s disease. Studies on the functional efficacy of intracerebral fetal cell transplants and GDNF delivery. (2002)

Winkler, Christian

Parkinson´s disease is characterized by a progressive degeneration of the nigral dopaminergic system. Treatment of disease symptoms using L-DOPA frequently induces side effects such as...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. (2002)

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J, ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of L-dopa in animals with lesions of the nigrostriatal pathway. The functional...

L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function. (2002)

Winkler, Christian, Kirik, Deniz, Björklund, Anders, Cenci, M Angela

In order to assess the role of striatal dopamine (DA) afferents in L-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine...

Determination of bound state wave functions by a genetic algorithm (1994)

Winkler, Christian, Hofmann, Hartmut M.

We apply a stochastic method of minimizing the ground state energy in variational calculations of light nuclei using the Refined Resonating Group Model (RRGM). The method utilizes a bit...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...

[Buchholzer Abraham]

Winkler, Christian (18 W.)

Mdz., 14,5 x 8,5 cm. Abraham Buchholzer (1529-1584), niem. teolog ewangelicki związany ze Śląskiem. Portret do pasa, 3/4 w l., w owalu, ustawiony na postumencie z herbem i napisem: "ABRAHAMUS...