Noranate, Nitchakarn, Prugnolle, Franck, Jouin, Hélène, Tall, Adama, Marrama, Laurence, Sokhna, Cheikh, ...
Abstract Background Genetic evidence for diversifying selection identified the Merozoite Surface Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against Plasmodium...
Steenkeste, Nicolas, Dillies, Marie-Agnès, Khim, Nimol, Sismeiro, Odile, Chy, Sophy, Lim, Pharath, ...
Abstract Background A number of molecular tools have been developed to monitor the emergence and spread of anti-malarial drug resistance to Plasmodium falciparum . One of the major obstacles to the...
Le Roux, Frederique, Zouine, Mohamed, Chakroun, Nesrine, Binesse, Johan, SAULNIER, Denis, Bouchier, Christiane, ...
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Lim, Pharath, Alker, Alisa P, Khim, Nimol, Shah, Naman K, Incardona, Sandra, Doung, Socheat, ...
Abstract Background The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000. However, recent clinical...
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
Mariette, Natacha, Barnadas, Céline, Bouchier, Christiane, Tichit, Magali, Ménard, Didier
Abstract Background Rapid diagnostic tests (RDTs) are becoming increasingly indispensable in malaria management, as a means of increasing the accuracy of diagnosis. The WHO has issued...
Frangeul, Lionel, Quillardet, Philippe, Castets, Anne-Marie, Humbert, Jean-François, Matthijs, Hans CP, Cortez, Diego, ...
Abstract Background The colonial cyanobacterium Microcystis proliferates in a wide range of freshwater ecosystems and is exposed to changing environmental factors during its life cycle. Microcystis...
Barnadas, Céline, Tichit, Magali, Bouchier, Christiane, Ratsimbasoa, Arsène, Randrianasolo, Laurence, Raherinjafy, Rogelin, ...
Abstract Background Four of five Plasmodium species infecting humans are present in Madagascar. Plasmodium vivax remains the second most prevalent species, but is understudied. No data is available...
Cadel-Six, Sabrina, Dauga, Catherine, Castets, Anne Marie, Rippka, Rosmarie, Bouchier, Christiane, Tandeau De Marsac, Nicole, ...
Cyanobacteria of the genus Microcystis are known to produce secondary metabolites of large structural diversity by nonribosomal peptide synthetase (NRPS) pathways. For a number of such compounds,...
Thierry, Agnès, Bouchier, Christiane, Dujon, Bernard, Richard, Guy-Franck
Minisatellites are DNA tandem repeats that are found in all sequenced genomes. In the yeast Saccharomyces cerevisiae, they are frequently encountered in genes encoding cell wall proteins....
Niang, Makhtar, Marrama, Laurence, Ekala, Marie Therese, Alioune, Gaye, Tall, Adama, Ndiaye, Jean L., ...
Objectives Chemoprophylaxis is recommended during pregnancy to reduce the risk of placental infection. However, in areas with increasing drug resistance, it can trigger selection of resistant...
Sequence analysis of Plasmodium falciparumcytochrome b in multiple geographic sites (2007)
Ekala, Marie-Thérèse, Khim, Nimol, Legrand, Eric, Randrianarivelojosia, Milijaona, Jambou, Ronan, Fandeur, Thierry, ...
Abstract Background The antimalarial drug atovaquone specifically targets Plasmodium falciparum cytochrome b ( Pfcytb ), a mitochondrial gene with uniparental inheritance. Cases of resistance to...
Stinear, Timothy P., Seemann, Torsten, Pidot, Sacha, Frigui, Wafa, Reysset, Gilles, Garnier, Thierry, ...
Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans, a neglected but devastating necrotic disease of subcutaneous tissue that is rampant throughout West and...
Invasion of Africa by a single pfcrtallele of South East Asian type (2006)
Ariey, Frédéric, Fandeur, Thierry, Durand, Remy, Randrianarivelojosia, Milijaona, Jambou, Ronan, Legrand, Eric, ...
Abstract Background Because of its dramatic public health impact, Plasmodium falciparum resistance to chloroquine (CQ) has been documented early on. Chloroquine-resistance (CQR) emerged in the late...
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae (2005)
Galagan, James E., Calvo, Sarah E., Cuomo, Christina, Ma, Li-Jun, Wortman, Jennifer R., Batzoglou, Serafim, ...
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a...
Nimol Khim, Christiane Bouchier, Marie-thérèse Ekala, Ra Incardona, Pharath Lim, Eric Legr, ...
Cambodia is located in an area of resistance to multiple antimalarials and has been the first country to implement the systematic use of an artesunate-mefloquine combination as first-line treatment...
Sequence analysis of a cDNA encoding a PLA2 from the sea-snake Aipysurus laevis (1988)
Ducancel, Frédéric, Guignery-Frelat, Gilberte, Bouchier, Christiane, Ménez, André, Boulain, Jean-Claude
Ducancel, Frédéric, Guignery-Frelat, Gilberte, Bouchier, Christiane, Ménez, André, Boulain, Jean-Claude
Cloning and sequencing of cDNAs encoding the two subunits of Crotoxin (1988)
Bouchier, Christiane, Ducancel, Frédéric, Guignery-Frelat, Gilberte, Bon, Cassian, Boulain, Jean-Claude, Ménez, André
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
Cornélis, François, Fauré, Sabine, Martinez, Maria, Prud’homme, Jean-François, Fritz, Pierre, Dib, Colette, ...
Rheumatoid arthritis (RA), the most common autoimmune disease, is associated in families with other autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM). Its genetic component...
Mlouka, Alyssa, Comte, Katia, Castets, Anne-Marie, Bouchier, Christiane, Tandeau De Marsac, Nicole
Microcystis aeruginosa is a planktonic unicellular cyanobacterium often responsible for seasonal mass occurrences at the surface of freshwater environments. An abundant production of intracellular...
Khim, Nimol, Bouchier, Christiane, Ekala, Marie-Thérèse, Incardona, Sandra, Lim, Pharath, Legrand, Eric, ...
Cambodia is located in an area of resistance to multiple antimalarials and has been the first country to implement the systematic use of an artesunate-mefloquine combination as first-line treatment...
Sielaff, Heike, Dittmann, Elke, Tandeau De Marsac, Nicole, Bouchier, Christiane, Von Döhren, Hans, Börner, Thomas, ...
Microcystins are hepatotoxic, non-ribosomal peptides produced by several genera of freshwater cyanobacteria. Among other enzymic activities, in particular those of peptide synthetases and polyketide...
Invasion of Africa by a single pfcrt allele of South East Asian type
Ariey, Frédéric, Fandeur, Thierry, Durand, Remy, Randrianarivelojosia, Milijaona, Jambou, Ronan, Legrand, Eric, ...
Weber, Christian, Guigon, Ghislaine, Bouchier, Christiane, Frangeul, Lionel, Moreira, Sandrine, Sismeiro, Odile, ...
Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene...
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
Cornélis, François, Fauré, Sabine, Martinez, Maria, Prud’homme, Jean-François, Fritz, Pierre, Dib, Colette, ...
Rheumatoid arthritis (RA), the most common autoimmune disease, is associated in families with other autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM). Its genetic component...
Mlouka, Alyssa, Comte, Katia, Castets, Anne-Marie, Bouchier, Christiane, Tandeau De Marsac, Nicole
Microcystis aeruginosa is a planktonic unicellular cyanobacterium often responsible for seasonal mass occurrences at the surface of freshwater environments. An abundant production of intracellular...
Khim, Nimol, Bouchier, Christiane, Ekala, Marie-Thérèse, Incardona, Sandra, Lim, Pharath, Legrand, Eric, ...
Cambodia is located in an area of resistance to multiple antimalarials and has been the first country to implement the systematic use of an artesunate-mefloquine combination as first-line treatment...
Sielaff, Heike, Dittmann, Elke, Tandeau De Marsac, Nicole, Bouchier, Christiane, Von Döhren, Hans, Börner, Thomas, ...
Microcystins are hepatotoxic, non-ribosomal peptides produced by several genera of freshwater cyanobacteria. Among other enzymic activities, in particular those of peptide synthetases and polyketide...
Weber, Christian, Guigon, Ghislaine, Bouchier, Christiane, Frangeul, Lionel, Moreira, Sandrine, Sismeiro, Odile, ...
Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene...
Invasion of Africa by a single pfcrt allele of South East Asian type
Ariey, Frédéric, Fandeur, Thierry, Durand, Remy, Randrianarivelojosia, Milijaona, Jambou, Ronan, Legrand, Eric, ...
Noranate, Nitchakarn, Durand, Rémy, Tall, Adama, Marrama, Laurence, Spiegel, André, Sokhna, Cheikh, ...
Stinear, Timothy P., Seemann, Torsten, Pidot, Sacha, Frigui, Wafa, Reysset, Gilles, Garnier, Thierry, ...
Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans, a neglected but devastating necrotic disease of subcutaneous tissue that is rampant throughout West and...
Legrand, Eric, Demar, Magalie, Volney, Béatrice, Ekala, Marie-Thérèse, Quinternet, Marc, Bouchier, Christiane, ...
Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites
Ekala, Marie-Thérèse, Khim, Nimol, Legrand, Eric, Randrianarivelojosia, Milijaona, Jambou, Ronan, Fandeur, Thierry, ...
Picardeau, Mathieu, Bulach, Dieter M., Bouchier, Christiane, Zuerner, Richard L., Zidane, Nora, Wilson, Peter J., ...
Leptospira biflexa is a free-living saprophytic spirochete present in aquatic environments. We determined the genome sequence of L. biflexa, making it the first saprophytic Leptospira to be...
Barnadas, Céline, Tichit, Magali, Bouchier, Christiane, Ratsimbasoa, Arsène, Randrianasolo, Laurence, Raherinjafy, Rogelin, ...
Genomic Diversity and Evolution of the Lyssaviruses
Delmas, Olivier, Holmes, Edward C., Talbi, Chiraz, Larrous, Florence, Dacheux, Laurent, Bouchier, Christiane, ...
Lyssaviruses are RNA viruses with single-strand, negative-sense genomes responsible for rabies-like diseases in mammals. To date, genomic and evolutionary studies have most often utilized partial...
Ziemert, Nadine, Ishida, Keishi, Quillardet, Philippe, Bouchier, Christiane, Hertweck, Christian, De Marsac, Nicole Tandeau, ...
Comparative analysis of related biosynthetic gene clusters can provide new insights into the versatility of these pathways and allow the discovery of new natural products. The freshwater...
Frangeul, Lionel, Quillardet, Philippe, Castets, Anne-Marie, Humbert, Jean-François, Matthijs, Hans CP, Cortez, Diego, ...
Zilliges, Yvonne, Kehr, Jan-Christoph, Mikkat, Stefan, Bouchier, Christiane, De Marsac, Nicole Tandeau, Börner, Thomas, ...
Microcystins are the most common cyanobacterial toxins found in freshwater lakes and reservoirs throughout the world. They are frequently produced by the unicellular, colonial cyanobacterium...
Cadel-Six, Sabrina, Dauga, Catherine, Castets, Anne Marie, Rippka, Rosmarie, Bouchier, Christiane, Tandeau De Marsac, Nicole, ...
Cyanobacteria of the genus Microcystis are known to produce secondary metabolites of large structural diversity by nonribosomal peptide synthetase (NRPS) pathways. For a number of such compounds,...
Thierry, Agnès, Bouchier, Christiane, Dujon, Bernard, Richard, Guy-Franck
Minisatellites are DNA tandem repeats that are found in all sequenced genomes. In the yeast Saccharomyces cerevisiae, they are frequently encountered in genes encoding cell wall proteins....
Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
Ménard, Didier, Andriantsoanirina, Valérie, Jahevitra, Martial, Barnadas, Céline, Tichit, Magali, Bouchier, Christiane, ...
Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
Touchon, Marie, Hoede, Claire, Tenaillon, Olivier, Barbe, Valérie, Baeriswyl, Simon, Bidet, Philippe, ...
The Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We...
European Bat Lyssavirus Transmission among Cats, Europe
Dacheux, Laurent, Larrous, Florence, Mailles, Alexandra, Boisseleau, Didier, Delmas, Olivier, Biron, Charlotte, ...
We identified 2 cases of European bat lyssavirus subtype 1 transmission to domestic carnivores (cats) in France. Bat-to-cat transmission is suspected. Low amounts of virus antigen in cat brain made...
Barnadas, Céline, Ratsimbasoa, Arsène, Tichit, Magali, Bouchier, Christiane, Jahevitra, Martial, Picot, Stéphane, ...
No data were available concerning Plasmodium vivax resistance to chloroquine (CQ) in Madagascar. We investigated the therapeutic efficacy of CQ in P. vivax malaria, the prevalence of mutations in the...
Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Barreiro, Luis B., Ben-Ali, Meriem, Quach, Hélène, Laval, Guillaume, Patin, Etienne, Pickrell, Joseph K., ...
Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes,...
Signatures of Purifying and Local Positive Selection in Human miRNAs
Quach, Hélène, Barreiro, Luis B., Laval, Guillaume, Zidane, Nora, Patin, Etienne, Kidd, Kenneth K., ...
MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional gene repression, and their role in diverse physiological processes is increasingly recognized. Yet, few efforts have been devoted...
Plasticity and Evolution of Aeruginosin Biosynthesis in Cyanobacteria▿ †
Ishida, Keishi, Welker, Martin, Christiansen, Guntram, Cadel-Six, Sabrina, Bouchier, Christiane, Dittmann, Elke, ...
Aeruginosins are bioactive oligopeptides that are produced in high structural diversity by strains of the bloom-forming cyanobacterial genera Microcystis and Planktothrix. A hallmark of aeruginosins...