Knies, Jennifer L., Dang, Kristen K., Vision, Todd J., Hoffman, Noah G., Swanstrom, Ronald, Burch, Christina L.
There is growing evidence that interactions between biological molecules (e.g., RNA–RNA, protein–protein, RNA–protein) place limits on the rate and trajectory of molecular evolution. Here, by...
The Genetic Basis of Thermal Reaction Norm Evolution in Lab and Natural Phage Populations (2006)
Jennifer L. Knies, Rima Izem, Katie L. Supler, Joel G. Kingsolver, Christina L. Burch
Extensive phenotypic characterisations and detailed genetic analyses of the genome sequences of experimentally evolved phage help to reveal the genetic basis of adaptation to temperature variation in...
The Genetic Basis of Thermal Reaction Norm Evolution in Lab and Natural Phage Populations (2006)
Jennifer L. Knies, Rima Izem, Katie L. Supler, Joel G. Kingsolver, Christina L. Burch
Two major goals of laboratory evolution experiments are to integrate from genotype to phenotype to fitness, and to understand the genetic basis of adaptation in natural populations. Here we...
Hybrid Frequencies Confirm Limit to Coinfection in the RNA Bacteriophage φ6
Turner, Paul E., Burch, Christina L., Hanley, Kathryn A., Chao, Lin
Coinfection of the same host cell by multiple viruses may lead to increased competition for limited cellular resources, thus reducing the fitness of an individual virus. Selection should favor...
The Genetic Basis of Thermal Reaction Norm Evolution in Lab and Natural Phage Populations
Knies, Jennifer L, Izem, Rima, Supler, Katie L, Kingsolver, Joel G, Burch, Christina L
Two major goals of laboratory evolution experiments are to integrate from genotype to phenotype to fitness, and to understand the genetic basis of adaptation in natural populations. Here we...
Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6
Duffy, Siobain, Turner, Paul E., Burch, Christina L.
Natural and experimental systems have failed to universally demonstrate a trade-off between generalism and specialism. When a trade-off does occur it is difficult to attribute its cause to...
Epistasis and its relationship to canalization in the RNA virus phi 6.
Although deleterious mutations are believed to play a critical role in evolution, assessing their realized effect has been difficult. A key parameter governing the effect of deleterious mutations is...
Hybrid Frequencies Confirm Limit to Coinfection in the RNA Bacteriophage φ6
Turner, Paul E., Burch, Christina L., Hanley, Kathryn A., Chao, Lin
Coinfection of the same host cell by multiple viruses may lead to increased competition for limited cellular resources, thus reducing the fitness of an individual virus. Selection should favor...
Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6
Duffy, Siobain, Turner, Paul E., Burch, Christina L.
Natural and experimental systems have failed to universally demonstrate a trade-off between generalism and specialism. When a trade-off does occur it is difficult to attribute its cause to...
Epistasis and its relationship to canalization in the RNA virus phi 6.
Although deleterious mutations are believed to play a critical role in evolution, assessing their realized effect has been difficult. A key parameter governing the effect of deleterious mutations is...
The Genetic Basis of Thermal Reaction Norm Evolution in Lab and Natural Phage Populations
Knies, Jennifer L, Izem, Rima, Supler, Katie L, Kingsolver, Joel G, Burch, Christina L
Two major goals of laboratory evolution experiments are to integrate from genotype to phenotype to fitness, and to understand the genetic basis of adaptation in natural populations. Here we...
Experimental Estimate of the Abundance and Effects of Nearly Neutral Mutations in the RNA Virus φ6
Burch, Christina L., Guyader, Sebastien, Samarov, Daniel, Shen, Haipeng
Although the frequency and effects of neutral and nearly neutral mutations are critical to evolutionary patterns and processes governed by genetic drift, the small effects of such mutations make them...
High Frequency of Mutations That Expand the Host Range of an RNA Virus
Ferris, Martin T., Joyce, Paul, Burch, Christina L.
The ability of a virus population to colonize a novel host is predicted to depend on the equilibrium frequency of potential colonists (i.e., genotypes capable of infecting the novel host) in the...
Optimal Foraging Predicts the Ecology but Not the Evolution of Host Specialization in Bacteriophages
Guyader, Sébastien, Burch, Christina L.
We explore the ability of optimal foraging theory to explain the observation among marine bacteriophages that host range appears to be negatively correlated with host abundance in the local marine...
Compensatory Evolution in RNA Secondary Structures Increases Substitution Rate Variation among Sites
Knies, Jennifer L., Dang, Kristen K., Vision, Todd J., Hoffman, Noah G., Swanstrom, Ronald, Burch, Christina L.
There is growing evidence that interactions between biological molecules (e.g., RNA–RNA, protein–protein, RNA–protein) place limits on the rate and trajectory of molecular evolution. Here, by...
Ince, William L., Harrington, Patrick R., Schnell, Gretja L., Patel-Chhabra, Milloni, Burch, Christina L., Menezes, Prema, ...
A distinctive feature of chronic human immunodeficiency virus type 1 (HIV-1) infection is the presence of multiple coexisting genetic variants, or subpopulations, that comprise the HIV-1 population...