Oberdoerffer, Philipp, Kanellopoulou, Chryssa, Heissmeyer, Vigo, Paeper, Corinna, Borowski, Christine, Aifantis, Iannis, ...
RNA interference (RNAi) is a naturally occurring posttranscriptional gene-silencing mechanism that has been adapted as a genetic tool for loss-of-function studies of a variety of organisms. It is...
Oberdoerffer, Philipp, Kanellopoulou, Chryssa, Heissmeyer, Vigo, Paeper, Corinna, Borowski, Christine, Aifantis, Iannis, ...
RNA interference (RNAi) is a naturally occurring posttranscriptional gene-silencing mechanism that has been adapted as a genetic tool for loss-of-function studies of a variety of organisms. It is...
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival
Mandal, Malay, Borowski, Christine, Palomero, Teresa, Ferrando, Adolfo A., Oberdoerffer, Philipp, Meng, Fanyong, ...
The pre–T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR–expressing cells are selected to survive...
Signaling for NKT cell development: the SAP–FynT connection
Borowski, Christine, Bendelac, Albert
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src...
Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
Borowski, Christine, Li, Xiaoyan, Aifantis, Iannis, Gounari, Fotini, Von Boehmer, Harald
In contrast with the αβ T cell receptor (TCR), the pre-TCR spontaneously segregates to membrane rafts from where it signals in a cell-autonomous fashion. The disparate behaviors of these two...