Riffkin, Christopher D., Gray, Amy Z., Hawkins, Christine J., Chow, C.W., Ashley, David M.
Fas (APO-1/CD95/TNFRSF6) is a member of the tumor necrosis/nerve growth factor receptor family that signals apoptotic cell death in sensitive cells. Expression of Fas and its agonistic ligand...
Hawkins, Christine J., Yoo, Soon Ji, Peterson, Erin P., Wang, Susan L., Vernooy, Stephanie Y., Hay, Bruce A.
The caspase family of cysteine proteases plays important roles in bringing about apoptotic cell death. All caspases studied to date cleave substrates COOH-terminal to an aspartate. Here we show that...
Hawkins, Christine J., Wang, Susan L., Hay, Bruce A.
Site-specific proteases play critical roles in regulating many cellular processes. To identify novel site-specific proteases, their regulators, and substrates, we have designed a general reporter...
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
Silke, John, Ekert, Paul G., Day, Catherine L., Hawkins, Christine J., Baca, Manuel, Chew, Joanne, ...
XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2...
Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane
Burri, Lena, Strahm, Yvan, Hawkins, Christine J., Gentle, Ian E., Puryer, Michelle A., Verhagen, Anne, ...
DIABLO/Smac is a mitochondrial protein that can promote apoptosis by promoting the release and activation of caspases. To do so, DIABLO/Smac must first be processed by a mitochondrial protease and...
Hawkins, Christine J., Wang, Susan L., Hay, Bruce A.
Site-specific proteases play critical roles in regulating many cellular processes. To identify novel site-specific proteases, their regulators, and substrates, we have designed a general reporter...
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
Silke, John, Ekert, Paul G., Day, Catherine L., Hawkins, Christine J., Baca, Manuel, Chew, Joanne, ...
XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2...
Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane
Burri, Lena, Strahm, Yvan, Hawkins, Christine J., Gentle, Ian E., Puryer, Michelle A., Verhagen, Anne, ...
DIABLO/Smac is a mitochondrial protein that can promote apoptosis by promoting the release and activation of caspases. To do so, DIABLO/Smac must first be processed by a mitochondrial protease and...
Ekert, Paul G., Read, Stuart H., Silke, John, Marsden, Vanessa S., Kaufmann, Hitto, Hawkins, Christine J., ...
Apoptosis after growth factor withdrawal or drug treatment is associated with mitochondrial cytochrome c release and activation of Apaf-1 and caspase-9. To determine whether loss of Apaf-1,...
Silke, John, Hawkins, Christine J., Ekert, Paul G., Chew, Joanne, Day, Catherine L., Pakusch, Miha, ...
The X-linked mammalian inhibitor of apoptosis protein (XIAP) has been shown to bind several partners. These partners include caspase 3, caspase 9, DIABLO/Smac, HtrA2/Omi, TAB1, the bone morphogenetic...
Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9
Ekert, Paul G., Silke, John, Hawkins, Christine J., Verhagen, Anne M., Vaux, David L.
MIHA is an inhibitor of apoptosis protein (IAP) that can inhibit cell death by direct interaction with caspases, the effector proteases of apoptosis. DIABLO is a mammalian protein that can bind to...
Vince, James E., Chau, Diep, Callus, Bernard, Wong, W. Wei-Lynn, Hawkins, Christine J., Schneider, Pascal, ...
Synthetic inhibitor of apoptosis (IAP) antagonists induce degradation of IAP proteins such as cellular IAP1 (cIAP1), activate nuclear factor κB (NF-κB) signaling, and sensitize cells to tumor...
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
Fletcher, Jamie I., Meusburger, Sarina, Hawkins, Christine J., Riglar, David T., Lee, Erinna F., Fairlie, W. Douglas, ...
A central issue in the control of apoptosis is whether its essential mediators Bax and Bak must be restrained by Bcl-2-like prosurvival relatives to prevent their damaging mitochondria and unleashing...