Christine Lascols

Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli (2009)

Cambau, Emmanuelle, Matrat, Stephanie, Pan, Xiao-Su, Roth Dit Bettoni, Romain, Corbel, Céline, Aubry, Alexandra, ...

Objectives Besifloxacin is a new fluoroquinolone in development for ocular use. We investigated its mode of action and resistance in two major ocular pathogens, Streptococcus pneumoniae and...

Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes (2008)

Cesaro, Annabelle, Bettoni, Romain Roth Dit, Lascols, Christine, Mérens, Audrey, Soussy, Claude James, Cambau, Emmanuelle

Objectives To investigate mutations in the type II topoisomerase genes in quinolone-resistant mutants selected from bacteria harbouring plasmid-borne qnr genes. Methods Mutants were selected by...

First detection of plasmid-mediated quinolone resistance in the community setting and in hospitalized patients in Switzerland (2008)

Liassine, Nadia, Zulueta-Rodriguez, Patricia, Corbel, Céline, Lascols, Christine, Soussy, Claude-James, Cambau, Emmanuelle

In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid (2006)

Cattoir, Vincent, Lesprit, Philippe, Lascols, Christine, Denamur, Erik, Legrand, Patrick, Soussy, Claude-James, ...

Objectives: To investigate quinolone resistance mechanisms in an Escherichia coli clinical isolate (Ar2) resistant to ofloxacin but susceptible to nalidixic acid selected after 10 days of ofloxacin...

In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid (2006)

Cattoir, Vincent, Lesprit, Philippe, Lascols, Christine, Denamur, Erik, Legrand, Patrick, Soussy, Claude-James, ...

Objectives: To investigate quinolone resistance mechanisms in an Escherichia coli clinical isolate (Ar2) resistant to ofloxacin but susceptible to nalidixic acid selected after 10 days of ofloxacin...

Effect of pH on the susceptibility of Helicobacter pylori to the ketolide telithromycin (HMR 3647) and clarithromycin (2001)

Lascols, Christine, Bryskier, André, Soussy, Claude-James, Tankovic, Jacques

Fast and Accurate Quantitative Detection of Helicobacter pylori and Identification of Clarithromycin Resistance Mutations in H. pylori Isolates from Gastric Biopsy Specimens by Real-Time PCR

Lascols, Christine, Lamarque, Dominique, Costa, Jean-Marc, Copie-Bergman, Christiane, Le Glaunec, Jeanne-Marie, Deforges, Lionel, ...

Rapid identification of patients infected with clarithromycin-resistant Helicobacter pylori without the need for culture can help to avoid useless prescriptions of clarithromycin. We developed and...

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Tankovic, Jacques, Lascols, Christine, Sculo, Quentin, Petit, Jean-Claude, Soussy, Claude-James

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and...

Fast and Accurate Quantitative Detection of Helicobacter pylori and Identification of Clarithromycin Resistance Mutations in H. pylori Isolates from Gastric Biopsy Specimens by Real-Time PCR

Lascols, Christine, Lamarque, Dominique, Costa, Jean-Marc, Copie-Bergman, Christiane, Le Glaunec, Jeanne-Marie, Deforges, Lionel, ...

Rapid identification of patients infected with clarithromycin-resistant Helicobacter pylori without the need for culture can help to avoid useless prescriptions of clarithromycin. We developed and...

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Tankovic, Jacques, Lascols, Christine, Sculo, Quentin, Petit, Jean-Claude, Soussy, Claude-James

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and...

A Plasmid-Borne Shewanella algae Gene, qnrA3, and Its Possible Transfer In Vivo between Kluyvera ascorbata and Klebsiella pneumoniae▿

Lascols, Christine, Podglajen, Isabelle, Verdet, Charlotte, Gautier, Valérie, Gutmann, Laurent, Soussy, Claude-James, ...

The plasmid-borne quinolone resistance gene qnrA1 is prevalent in multidrug-resistant Enterobacteriaceae. A chromosomally encoded homologue in Shewanella algae, qnrA3, has been described. We isolated...

The Pentapeptide Repeat Proteins MfpAMt and QnrB4 Exhibit Opposite Effects on DNA Gyrase Catalytic Reactions and on the Ternary Gyrase-DNA-Quinolone Complex▿ †

Mérens, Audrey, Matrat, Stéphanie, Aubry, Alexandra, Lascols, Christine, Jarlier, Vincent, Soussy, Claude-James, ...

MfpAMt and QnrB4 are two newly characterized pentapeptide repeat proteins (PRPs) that interact with DNA gyrase. The mfpAMt gene is chromosome borne in Mycobacterium tuberculosis, while qnrB4 is...