Christoph Loddenkemper

Chronic norovirus infection in renal transplant recipients (2009)

Westhoff, Timm H., Vergoulidou, Maria, Loddenkemper, Christoph, Schwartz, Stefan, Hofmann, Jörg, Schneider, Thomas, ...

Norovirus infection is the most common cause of acute gastroenteritis. In immunocompetent subjects, norovirus infection is a self-limiting disease of short duration. The present report provides first...

Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1 (2008)

Schrage, Arnhild, Loddenkemper, Christoph, Erben, Ulrike, Lauer, Uta, Hausdorf, Gert, Jungblut, Peter R., ...

Autoregulation of Th1-mediated inflammation by twist1 (2008)

Niesner, Uwe, Albrecht, Inka, Janke, Marko, Doebis, Cornelia, Loddenkemper, Christoph, Lexberg, Maria H., ...

The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor {kappa}B (NF-{kappa}B)–dependent cytokine expression, is involved in the regulation of...

Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. (2008)

Doebis, Cornelia, Siegmund, Kerstin, Loddenkemper, Christoph, Lowe, John B., Issekutz, Andrew C., Hamann, Alf, ...

Delayed-type hypersensitivity (DTH) reactions are characterized by a strong cellular infiltrate, including neutrophils, macrophages, and T lymphocytes. In all these cell types, both E- and...

Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival (2007)

Nagorsen, Dirk, Voigt, Sabine, Berg, Erika, Stein, Harald, Thiel, Eckhard, Loddenkemper, Christoph

Abstract Introduction Although systemic T-cell responses against tumor antigens and tumor infiltration by T cells have been investigated in colorectal cancer (CRC), the initiation of spontaneous...

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf (2007)

Bouchard, Caroline, Lee, Soyoung, Paulus-Hock, Viola, Loddenkemper, Christoph, Eilers, Martin, Schmitt, Clemens A.

FoxO transcription factors play critical roles in cell cycle control and cellular stress responses, and abrogation of FoxO function promotes focus formation by Myc in vitro. Here we show that stable...

High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma (2007)

Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Korfel, Agnieszka

In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...

High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma (2007)

Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka

In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...

Nf-{kappa}b and AP-1 activation is associated with late lumen loss after porcine coronary angioplasty and antiproliferative beta-irradiation (2007)

Deiner, Carolin, Shagdarsuren, Erdenechimeg, Schwimmbeck, Peter L., Rosenthal, Peter, Loddenkemper, Christoph, Rauch, Ursula, ...

Objective Despite the success of antiproliferative therapies, restenosis remains a common problem after percutaneous transluminal coronary angioplasty (PTCA). Longer-term clinical results of...

High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma (2007)

Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka

In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...

High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma (2007)

Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Korfel, Agnieszka

In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...

High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma (2007)

Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka

In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...

In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer (2006)

Loddenkemper, Christoph, Schernus, Martin, Noutsias, Michel, Stein, Harald, Thiel, Eckhard, Nagorsen, Dirk

Abstract The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the...

Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis (2006)

Appel, Heiner, Loddenkemper, Christoph, Grozdanovic, Zarko, Ebhardt, Harald, Dreimann, Marc, Hempfing, Axel, ...

Abstract Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI)...

A novel sporadic Burkitt lymphoma cell line (BLUE-1) with a unique t(6;20)(q15;q11.2) rearrangement (2006)

Burmeister, Thomas, MacLeod, Roderick A. F., Reinhardt, Richard, Mansmann, Veit, Loddenkemper, Christoph, Marinets, Olga, ...

We report the establishment and characterization, including HLA-typing, immunophenotypic and molecular cytogenetic analysis, of a novel EBV-negative cell line (BLUE-1) derived from adult relapsed...

Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III (2006)

Groene, Joern, Mansmann, Ulrich, Meister, Reinhard, Staub, Eike, Roepcke, Stefan, Heinze, Maya, ...

UICC stage II and III colorectal cancers (CRC) differ fundamentally in prognosis and therapeutic concepts. To analyze differential gene expression between both stages and to establish a relationship...

Proteasome-mediated degradation of I{kappa}B{alpha} and processing of p105 in Crohn disease and ulcerative colitis (2006)

Visekruna, Alexander, Joeris, Thorsten, Seidel, Daniel, Kroesen, Anjo, Loddenkemper, Christoph, Zeitz, Martin, ...

Cutaneous Mycobacterium abscessus infection after kidney transplantation (2005)

Scholze, Alexandra, Loddenkemper, Christoph, Grünbaum, Maria, Moosmayer, Ines, Offermann, Gerd, Tepel, Martin

Biliary casts in the kidney tubule (2005)

Hörl, Matthias P., Loddenkemper, Christoph, Korfel, Agnieszka, Tepel, Martin

Cutaneous Mycobacterium abscessus infection after kidney transplantation (2005)

Scholze, Alexandra, Loddenkemper, Christoph, Grünbaum, Maria, Moosmayer, Ines, Offermann, Gerd, Tepel, Martin

Cutaneous Mycobacterium abscessus infection after kidney transplantation (2005)

Scholze, Alexandra, Loddenkemper, Christoph, Grünbaum, Maria, Moosmayer, Ines, Offermann, Gerd, Tepel, Martin

Immunhistologische Expressionsanalyse des CTNNB1-Genproduktes-([beta]-Catenin) [CTNNB1-Genproduktes-(beta-Catenin)] bei Ovarialkarzinomem / (2001)

Loddenkemper, Christoph.

Berlin, Humboldt-Univ., Diss., 2001.

Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis

Visekruna, Alexander, Joeris, Thorsten, Seidel, Daniel, Kroesen, Anjo, Loddenkemper, Christoph, Zeitz, Martin, ...

Enhanced NF-κB activity is involved in the pathology of both forms of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Here we analyzed the mechanism of...

Proteasome-mediated degradation of IκBα and processing of p105 in Crohn disease and ulcerative colitis

Visekruna, Alexander, Joeris, Thorsten, Seidel, Daniel, Kroesen, Anjo, Loddenkemper, Christoph, Zeitz, Martin, ...

Enhanced NF-κB activity is involved in the pathology of both forms of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Here we analyzed the mechanism of...

In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer

Loddenkemper, Christoph, Schernus, Martin, Noutsias, Michel, Stein, Harald, Thiel, Eckhard, Nagorsen, Dirk

The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the interaction...

Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis

Appel, Heiner, Loddenkemper, Christoph, Grozdanovic, Zarko, Ebhardt, Harald, Dreimann, Marc, Hempfing, Axel, ...

Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the...

Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification

Loddenkemper, Christoph, Longerich, Thomas, Hummel, Michael, Ernestus, Karen, Anagnostopoulos, Ioannis, Dienes, Hans-Peter, ...

The recent World Health Organization (WHO) classification of hematopoietic and lymphoid tissue tumors represents the first worldwide consensus classification of these malignancies. However, the...

Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4

Heimesaat, Markus M., Fischer, André, Siegmund, Britta, Kupz, Andreas, Niebergall, Julia, Fuchs, David, ...

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Lahl, Katharina, Loddenkemper, Christoph, Drouin, Cathy, Freyer, Jennifer, Arnason, Jon, Eberl, Gérard, ...

The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3...

Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival

Nagorsen, Dirk, Voigt, Sabine, Berg, Erika, Stein, Harald, Thiel, Eckhard, Loddenkemper, Christoph

High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma

Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka

In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf

Bouchard, Caroline, Lee, Soyoung, Paulus-Hock, Viola, Loddenkemper, Christoph, Eilers, Martin, Schmitt, Clemens A.

FoxO transcription factors play critical roles in cell cycle control and cellular stress responses, and abrogation of FoxO function promotes focus formation by Myc in vitro. Here we show that stable...

Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection▿

Rausch, Sebastian, Huehn, Jochen, Kirchhoff, Dennis, Rzepecka, Justyna, Schnoeller, Corinna, Pillai, Smitha, ...

Parasitic nematodes typically modulate T-cell reactivity, primarily during the chronic phase of infection. We analyzed the role of CD4-positive (CD4+) T effector (Teff) cells and regulatory T (Treg)...

Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness

Willimsky, Gerald, Czéh, Melinda, Loddenkemper, Christoph, Gellermann, Johanna, Schmidt, Karin, Wust, Peter, ...

Cancer is sporadic in nature, characterized by an initial clonal oncogenic event and usually a long latency. When and how it subverts the immune system is unknown. We show, in a model of sporadic...

Autoregulation of Th1-mediated inflammation by twist1

Niesner, Uwe, Albrecht, Inka, Janke, Marko, Doebis, Cornelia, Loddenkemper, Christoph, Lexberg, Maria H., ...

The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor κB (NF-κB)–dependent cytokine expression, is involved in the regulation of inflammation-induced...

Cytokine Expression in the Colonic Mucosa of Human Immunodeficiency Virus-Infected Individuals before and during 9 Months of Antiretroviral Therapy▿

Schulbin, Hubert, Bode, Hagen, Stocker, Hartmut, Schmidt, Wolfgang, Zippel, Thomas, Loddenkemper, Christoph, ...

High-level human immunodeficiency virus (HIV) replication and the rapid breakdown of the mucosal immune system are the hallmarks of HIV infection in the gut. Cytokine dysregulation may be related to...

Cellular Players and Role of Selectin Ligands in Leukocyte Recruitment in a T-Cell-Initiated Delayed-Type Hypersensitivity Reaction

Doebis, Cornelia, Siegmund, Kerstin, Loddenkemper, Christoph, Lowe, John B., Issekutz, Andrew C., Hamann, Alf, ...

Delayed-type hypersensitivity (DTH) reactions are characterized by a strong cellular infiltrate, including neutrophils, macrophages, and T lymphocytes. In all these cell types, both E- and...

Ki-67 as a prognostic marker in mantle cell lymphoma—consensus guidelines of the pathology panel of the European MCL Network

Klapper, Wolfram, Hoster, Eva, Determann, Olaf, Oschlies, Ilske, Van Der Laak, Jeroen, Berger, Françoise, ...

Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the...

Leptospirosis in Urban Wild Boars, Berlin, Germany

Jansen, Andreas, Luge, Enno, Guerra, Beatriz, Wittschen, Petra, Gruber, Achim D., Loddenkemper, Christoph, ...

We found antibodies to leptospires in 25 (18%) of 141 wild boars from Berlin (95% confidence interval 12–25). Seropositivity was associated with chronic interstitial nephritis (odds ratio 10.5; p =...

Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1

Schrage, Arnhild, Loddenkemper, Christoph, Erben, Ulrike, Lauer, Uta, Hausdorf, Gert, Jungblut, Peter R., ...

The endothelium plays an important role in the exchange of molecules, but also of immune cells between blood and the underlying tissue. The endothelial molecule S-Endo 1 antigen (CD146) is...

Rapid and Accurate Diagnosis of Human Intestinal Spirochetosis by Fluorescence In Situ Hybridization▿

Schmiedel, Dinah, Epple, Hans-Jörg, Loddenkemper, Christoph, Ignatius, Ralf, Wagner, Jutta, Hammer, Bettina, ...

Human intestinal spirochetosis (HIS) is associated with overgrowth of the large intestine by spirochetes of the genus Brachyspira. The microbiological diagnosis of HIS is hampered by the fastidious...