Christopher C. Kemball

Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection (2006)

Kemball, Christopher C., Lee, Eun D. Han, Szomolanyi-Tsuda, Eva, Pearson, Thomas A., Larsen, Christian P., Lukacher, Aron E.

The requirement for costimulation in antiviral CD8+ T cell responses has been actively investigated for acutely resolved viral infections, but it is less defined for CD8+ T cell responses to...

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

Vezys, Vaiva, Masopust, David, Kemball, Christopher C., Barber, Daniel L., O'Mara, Leigh A., Larsen, Christian P., ...

Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and...

Allogeneic Differences in the Dependence on CD4+ T-Cell Help for Virus-Specific CD8+ T-Cell Differentiation▿

Kemball, Christopher C., Szomolanyi-Tsuda, Eva, Lukacher, Aron E.

CD4+ T-cell help enables antiviral CD8+ T cells to differentiate into fully competent memory cells and sustains CD8+ T-cell-mediated immunity during persistent virus infection. We recently reported...

Enumeration and Functional Evaluation of Virus-Specific CD4+ and CD8+ T Cells in Lymphoid and Peripheral Sites of Coxsackievirus B3 Infection▿

Kemball, Christopher C., Harkins, Stephanie, Whitton, J. Lindsay

Previous studies have suggested that coxsackievirus B (CVB) activates CD8+ T cells in vivo, but the extent of this activation and the antigen specificity of the CD8+ T cells remain uncertain....

Coxsackievirus B3 Inhibits Antigen Presentation In Vivo, Exerting a Profound and Selective Effect on the MHC Class I Pathway

Kemball, Christopher C., Harkins, Stephanie, Whitmire, Jason K., Flynn, Claudia T., Feuer, Ralph, Whitton, J. Lindsay

Many viruses encode proteins whose major function is to evade or disable the host T cell response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively strong T cell...