Christopher C. Norbury

Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo (2001)

Norbury, Christopher C., Princiotta, Michael F., Bacik, Igor, Brutkiewicz, Randy R., Wood, Phillip, Elliott, Tim, ...

Current knowledge of the processing of viral Ags into MHC class I-associated ligands is based almost completely on in vitro studies using nonprofessional APCs (pAPCs). This is two steps removed from...

Drinking a lot is good for dendritic cells

Norbury, Christopher C

Macropinocytosis is the actin-dependent formation of large vesicles, which allow the internalization of large quantities of fluid-phase solute. In the majority of cells examined, an exogenous...

Cross-priming utilizes antigen not available to the direct presentation pathway

Donohue, Keri B, Grant, Jean M, Tewalt, Eric F, Palmer, Douglas C, Theoret, Marc R, Restifo, Nicholas P, ...

CD8+ T cells play a crucial role in protective immunity to viruses and tumours. Antiviral CD8+ T cells are initially activated by professional antigen presenting cells (pAPCs) that are directly...

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

Reiley, William W., Jin, Wei, Lee, Andrew Joon, Wright, Ato, Wu, Xuefeng, Tewalt, Eric F., ...

The deubiquitinating enzyme CYLD has recently been implicated in the regulation of signal transduction, but its physiological function and mechanism of action are still elusive. In this study, we...

Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex

Gretz, J. Elizabeth, Norbury, Christopher C., Anderson, Arthur O., Proudfoot, Amanda E.I., Shaw, Stephen

Lymph-borne, soluble factors (e.g., chemokines and others) influence lymphocyte recirculation and endothelial phenotype at high endothelial venules (HEVs) in lymph node cortex. Yet the route...

Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens

Chen, Weisan, Norbury, Christopher C., Cho, Yunjung, Yewdell, Jonathan W., Bennink, Jack R.

Vertebrates express three cytokine-inducible proteasome subunits that are incorporated in the place of their constitutively synthesized counterparts. There is increasing evidence that the set of...

Corticosterone impairs dendritic cell maturation and function

Elftman, Michael D, Norbury, Christopher C, Bonneau, Robert H, Truckenmiller, Mary E

Dendritic cells (DC) play a critical role in initiating and directing adaptive immune responses against pathogens and tumours. Immature DC are thought to act as sentinels in peripheral tissues where...

Viral Sequestration of Antigen Subverts Cross Presentation to CD8+ T Cells

Tewalt, Eric F., Grant, Jean M., Granger, Erica L., Palmer, Douglas C., Heuss, Neal D., Gregerson, Dale S., ...

Virus-specific CD8+ T cells (TCD8+) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two...