Zhang, Junlong, Zhang, Fang, Didelot, Xavier, Bruce, Kimberley D, Cagampang, Felino R, Vatish, Manu, ...
Abstract Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is...
Zhang, Junlong, Zhang, F. (Fang), Didelot, Xavier, Bruce, Kimberley D., Cagampang, Felino R., Vatish, Manu, ...
Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known...
Clough, Geraldine F., Turzyniecka, Magdalena, Walter, Lara, Krentz, Andrew J., Wild, Sarah H., Chipperfield, Andrew J., ...
OBJECTIVE: To test the hypotheses that decreased insulin-mediated glucose disposal in muscle is associated with a reduced muscle microvascular exchange capacity (Kf) and that 6 months of high-dose...
Richard M. Lawn, Nataya W. Boonmark, Karen Schwartz, Gisela E. Lindahl, David P. Wade, Christopher D. Byrne, ...
The lipoprotein Lp(a), a major inherited risk factor for atherosclerosis, consists of a low density lipoproteinlike particle containing apolipoprotein B-100 plus the distinguishing component...
Current treatment of non-alcoholic fatty liver disease (2008)
Ahmed, Mohamed H., Byrne, Christopher D.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in Western World and frequently associated with insulin resistance and overweight and occurs often with type 2...
Englyst, Nicola A., Horsfield, Gill, Kwan, Joseph, Byrne, Christopher D.
The aim of this study was to investigate the relationship between aspirin resistance, ischaemic stroke subtype, stroke severity, and inflammatory cytokines. Aspirin resistance was assessed by...
Ahmed, Mohamed H., Byrne, Christopher D.
Non-alcoholic fatty liver disease (NAFLD) is associated with diabetes, obesity and insulin resistance. The pathogenesis of NAFLD is complex, but modulation of the activities of transcription factors...
Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C (2007)
Englyst, Nicola A., Grimble, Robert F., Byrne, Christopher D.
It has recently and controversially been demonstrated that fish oil supplementation may not be beneficial for everyone, but to date there have been no biological explanations. We suggest that...
The metabolic syndrome and primary care (2007)
Byrne, Christopher D., Wild, Sarah H.
The metabolic syndrome has become a ‘hot topic’ and is of increasing importance to people working in primary care. The global epidemics of diabetes and obesity are driving another in...
Englyst, Nicola A., Crook, Martin A., Lumb, Peter, Stears, Anna J., Masding, Michael G., Wootton, Stephen A., ...
Circulating sialic acid is an independent risk factor for cardiovascular disease and is higher in people with type 2 diabetes mellitus. Sialic acid is associated with body mass index, but it is...
Effects of VLDL and remnant particles on platelets (2006)
Olufadi, Rasaq, Byrne, Christopher D.
There is a considerable body of evidence supporting an association between hypertriglyceridaemia, a hypercoagulable state and atherothrombosis. A disorder of triglyceride metabolism is a key feature...
Reynolds, Rebecca M., Fischbacher, Colin, Bhopal, Raj, Byrne, Christopher D., White, Martin, Unwin, Nigel, ...
OBJECTIVE: The metabolic syndrome is more prevalent in South Asians in Britain than in the general population. Furthering our understanding of the underlying mechanisms is important because of the...
Wild, Sarah H., Byrne, Christopher D., Smith, Felicity B., Lee, Amanda J., Fowkes, F. Gerald
OBJECTIVE—To investigate whether a low ankle-brachial pressure index (ABI) predicts increased risk of cardiovascular disease (CVD) independent of the metabolic syndrome and conventional...
Englyst, Nicola A., Crook, Martin A., Lumb, Peter, Stears, Anna J., Masding, Michael G., Wootton, Stephen A., ...
Circulating sialic acid is an independent risk factor for cardiovascular disease and is higher in people with type 2 diabetes mellitus. Sialic acid is associated with body mass index, but it is...
Zhang, Junlong, Holt, Helen, Wang, Chunli, Hadid, Omar H., Byrne, Christopher D.
The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 and AdipoR2) (5). AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is also...
Othman, Maha, Notley, Coleen, Lavender, Francis Louise, White, Helen, Byrne, Christopher D., Lillicrap, David, ...
Interaction between the platelet glycoprotein Ib (GPIb) receptor and its adhesive ligand von Willebrand factor (VWF) has a critical role in the process of hemostasis. Platelet-type von Willebrand...
Wild, Sarah H., Byrne, Christopher D.
The metabolic syndrome is present in approximately 20% of general populations in developed countries and in approximately 80% of people with type 2 diabetes. High triglyceride levels, low...
Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses (2005)
Zhang, Junlong, Lewis, Rohan M., Wang, Chunli, Hales, Nicholas, Byrne, Christopher D.
Maternal dietary Fe restriction reduced fasting plasma cholesterol and triglyceride (TG) concentrations in the fetuses, as well as decreased plasma TG levels in the adult offspring. To investigate...
Zhang, Junlong, Wang, Chunli, Terroni, Paul L., Cagampang, Felino R.A., Hanson, Mark, Byrne, Christopher D.
Whether a high-unsaturated-fat, high-protein (HFP), and low-carbohydrate (CHO) diet during gestation has long-lasting beneficial effects on lipid metabolism in the offspring was investigated using a...
Zhang, Junlong, Holt, Richard I.G., Wild, Sarah H., Poole, Ruth B., Holt, Helen, Byrne, Christopher D.
Adiponectin is an abundant plasma protein, mainly secreted by adipocytes and closely linked to insulin sensitivity (1–4). Plasma adiponectin independently correlates with insulin sensitivity (5)....
Richardson, Malcolm C., Cameron, Iain T., Simonis, Chantal D., Das, Madhab C., Hodge, Tessa E., Zhang, Junlong, ...
The isoforms of sterol regulatory element-binding proteins (SREBP) (1a, 1c, and 2) are key transcriptional regulators of lipid biosynthesis. We examined their regulation by gonadotropin and insulin...
Evidence for fetal programming of obesity with a focus on putative mechanisms (2004)
Wild, Sarah H., Byrne, Christopher D.
Obesity is associated with insulin resistance, the metabolic syndrome (a clustering of three or more of increased waist circumference, blood pressure, fasting glucose and fasting plasma...
Cost-outcome benefits of fibrate therapy in type 2 diabetes (2003)
Feher, Michael D., Langley-Hawthorne, Clare E., Byrne, Christopher D.
To date there have been few studies focusing on economic assessments of fibrate therapy in the management of coronary heart disease (CHD), particularly in patients with type 2 diabetes. A...
Whorwood, Christopher B., Donovan, Stephen J., Flanagan, Daniel, Phillips, David I.W., Byrne, Christopher D.
Altered glucocorticoid hormone action may contribute to the etiology of the metabolic syndrome, but the molecular mechanisms are poorly defined. Tissue sensitivity to glucocorticoid is regulated by...
Zhang, Junlong, Day, Ian N.M., Byrne, Christopher D.
There is a great demand for technologies to simultaneously measure mRNA levels from multiple genes. Here we report a new quantitative competitive PCR technology and demonstrate simultaneous...
Zhang, Junlong, Day, Ian N.M., Byrne, Christopher D.
There is a great demand for technologies to simultaneously measure mRNA levels from multiple genes. Here we report a new quantitative competitive PCR technology and demonstrate simultaneous...
Zhang, Junlong, Day, Ian N.M., Byrne, Christopher D.
There is a great demand for technologies to simultaneously measure mRNA levels from multiple genes. Here we report a new quantitative competitive PCR technology and demonstrate simultaneous...
Zhang, Junlong, Day, Ian N. M., Byrne, Christopher D.
There is a great demand for technologies to simultaneously measure mRNA levels from multiple genes. Here we report a new quantitative competitive PCR technology and demonstrate simultaneous...
Programming other hormones that affect insulin (2001)
The metabolic syndrome is associated with a marked increase in risk of type 2 diabetes and atherosclerotic vascular disease (AVD). The mechanism responsible for the metabolic syndrome is uncertain,...
Suppressing thrombin generation is compatible with the development of atherosclerosis in mice (2001)
Grainger, David J., McWilliam, Nicola A., Baglin, Trevor P., Byrne, Christopher D.
Thrombin has been proposed to play a key role in the development of atherosclerosis, both by promoting fibrin deposition into the atherosclerotic vessel wall and also by signalling through thrombin...
Little, Paul, Byrne, Christopher D.
Generalised obesity, measured by body mass index (weight (kg)/(height (m)2)), is one of the major causes of ill health in western society. However, abdominal obesitywhich is closely associated with...
Talmud, Philippa J., Palmen, Jutta, Luan, Jian'an, Flavell, Dave, Byrne, Christopher D., Waterworth, Dawn M., ...
We previously identified a hormone sensitive lipase (HSL) promoter variant, −60C>G, which in vitro exhibits 40% reduced promoter activity. In this study we examined the effect of the −60C>G on...
Maison, Patrick, Byrne, Christopher D., Hales, C. Nicholas, Day, Nicholas E., Wareham, Nicholas J.
OBJECTIVE—The metabolic syndrome is a loosely defined cluster of cardiovascular risk factors including low HDL cholesterol, hypertriglyceridemia, glucose intolerance, and hypertension. Evidence for...
The benefits of a Mediterranean diet, statins, aspirin and unsaturated fats (2001)
Wild, Sarah. H., Byrne, Christopher. D.
Various pharmacological and non-pharmacological interventions are effective in both preventing and reducing complications from atherosclerotic vascular disease (AVD). The purpose of this brief review...
Programming other hormones that affect insulin: Type 2 diabetes (2001)
The metabolic syndrome is associated with a marked increase in risk of type 2 diabetes and atherosclerotic vascular disease (AVD). The mechanism responsible for the metabolic syndrome is uncertain,...
Zhang, Junlong, Day, Ian N. M., Byrne, Christopher D.
There is a great demand for technologies to simultaneously measure mRNA levels from multiple genes. Here we report a new quantitative competitive PCR technology and demonstrate simultaneous...
Zhang, Junlong, Day, Ian N. M., Byrne, Christopher D.
There is a great demand for technologies to simultaneously measure mRNA levels from multiple genes. Here we report a new quantitative competitive PCR technology and demonstrate simultaneous...