Christopher D. M. Fletcher

Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene (2005)

Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...

Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either more benign or more malignant tumor types. Cytogenetic analyses...

Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. (2005)

Mertens, Fredrik, Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...

Abstract is not available

Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12) (2004)

Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...

Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...

Activation of the GLI Oncogene through Fusion with the beta-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12). (2004)

Dahlén, Anna, Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...

Abstract is not available

The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (2004)

Panagopoulos, Ioannis, Tiziana Storlazzi, Clelia, Fletcher, Christopher D M, Fletcher, Jonathan A, Nascimento, Antonio, Domanski, Henryk A, ...

Abstract is not available

Soft tissue sarcomas of adults: state of the translational science (2003)

Baker, Laurence H, Bell, Robert S, Bramwell, Vivien, Demetri, George D, Eisenberg, Burton L, ...

Sarcomas--like leukemias, which are also mesodermal malignancies--carry biological significance disproportionate to their clinical frequency. Identification of mutations and translocations associated...

Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma (2002)

Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...

Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...

Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group (2002)

Strömberg, Ulf, Mandahl, Nils, Fletcher, Christopher D M, ...

Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...

Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma) (2002)

Weremowicz, Stanislawa, ...

Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma...

Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group (2002)

Dorfman, Howard, Brys, Peter, Fletcher, Christopher D M, ...

The evaluation of chondroid lesions requires full integration of clinical, radiographic, and pathological data; tumour typing is often a challenge for the diagnostic pathologist. Although a variety...

Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group. (2002)

Mertens, Fredrik, Strömberg, Ulf, Mandahl, Nils, Cin, Paola Dal, De Wever, Ivo, Fletcher, Christopher D M, ...

Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...

Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. (2002)

Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...

Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...

Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: a report from the CHAMP Study Group (2000)

Fletcher, Christopher D. M, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...

Afdeling Oncologische heelkunde. Departement Menselijke erfelijkheid.

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

Roberts, Charles W. M., Galusha, Shelly A., McMenamin, Máirín E., Fletcher, Christopher D. M., Orkin, Stuart H.

Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. Tumors occur in various locations, including kidney, brain, and soft tissues. Despite intensive therapy, 80%...

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

Demetri, George D., Fletcher, Christopher D. M., Mueller, Elisabetta, Sarraf, Pasha, Naujoks, Ryan, Campbell, Natalee, ...

Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-γ have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro....

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...

TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...

Adults With Ewing’s Sarcoma/Primitive Neuroectodermal Tumor: Adverse Effect of Older Age and Primary Extraosseous Disease on Outcome

Baldini, Elizabeth H., Demetri, George D., Fletcher, Christopher D. M., Foran, James, Marcus, Karen C., Singer, Samuel

Response to Chemotherapy and Predictors of Survival in Adult Rhabdomyosarcoma

Esnaola, Nestor F., Rubin, Brian P., Baldini, Elizabeth H., Vasudevan, Naren, Demetri, George D., Fletcher, Christopher D. M., ...

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

Roberts, Charles W. M., Galusha, Shelly A., McMenamin, Máirín E., Fletcher, Christopher D. M., Orkin, Stuart H.

Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. Tumors occur in various locations, including kidney, brain, and soft tissues. Despite intensive therapy, 80%...

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

Demetri, George D., Fletcher, Christopher D. M., Mueller, Elisabetta, Sarraf, Pasha, Naujoks, Ryan, Campbell, Natalee, ...

Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-γ have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro....

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...

TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...

Adults With Ewing’s Sarcoma/Primitive Neuroectodermal Tumor: Adverse Effect of Older Age and Primary Extraosseous Disease on Outcome

Baldini, Elizabeth H., Demetri, George D., Fletcher, Christopher D. M., Foran, James, Marcus, Karen C., Singer, Samuel

Response to Chemotherapy and Predictors of Survival in Adult Rhabdomyosarcoma

Esnaola, Nestor F., Rubin, Brian P., Baldini, Elizabeth H., Vasudevan, Naren, Demetri, George D., Fletcher, Christopher D. M., ...

Activation of the GLI Oncogene through Fusion with the β-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12)

Dahlén, Anna, Fletcher, Christopher D. M., Mertens, Fredrik, Fletcher, Jonathan A., Perez-Atayde, Antonio R., Hicks, M. John, ...

Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...

Expression of the Vascular Endothelial Growth Factor C Receptor VEGFR-3 in Lymphatic Endothelium of the Skin and in Vascular Tumors

Lymboussaki, Athina, Partanen, Taina A., Olofsson, Birgitta, Thomas-Crusells, Judith, Fletcher, Christopher D. M., ...

It is difficult to identify lymph vessels in tissue sections by histochemical staining, and thus a specific marker for lymphatic endothelial cells would be more practical in histopathological...

KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors

Lux, Marcia L., Rubin, Brian P., Biase, Tara L., Chen, Chang-Jie, Maclure, Timothy, Demetri, George, ...

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms arising in the gastrointestinal tract. GISTs express the KIT receptor tyrosine kinase, and many cases have activating...

Correlation between Clinicopathological Features and Karyotype in Spindle Cell Sarcomas : A Report of 130 Cases from the CHAMP Study Group

Fletcher, Christopher D. M., Dal Cin, Paola, De Wever, Ivo, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...

Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far,...

TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors

Lawrence, Brandon, Perez-Atayde, Antonio, Hibbard, Michele K., Rubin, Brian P., Dal Cin, Paola, Pinkus, Jack L., ...

Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations featuring an inflammatory infiltrate composed primarily of lymphocytes and plasma cells. The myofibroblastic cells...

KIT Gene Mutations in Gastrointestinal Stromal Tumors : More Complex than Previously Recognized?

Fletcher, Jonathan A., Fletcher, Christopher D.M., Rubin, Brian P., Ashman, Leonie K., Corless, Christopher L., Heinrich, Michael C.

Gastrointestinal Stromal Tumours: An Update

Fletcher, Christopher D. M.

Purpose. To study the evolution of concepts concerning gastrointestinal stromal tumours (GISTs) over 30 years.

Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

Heinrich, Michael C., Maki, Robert G., Corless, Christopher L., Antonescu, Cristina R., Harlow, Amy, Griffith, Diana, ...

Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group

Heinrich, Michael C., Owzar, Kouros, Corless, Christopher L., Hollis, Donna, Borden, Ernest C., Fletcher, Christopher D.M., ...