Jean-Philippe Coppé, Christopher K. Patil, Francis Rodier, Yu Sun, Denise P. Muñoz, Joshua Goldstein, ...
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to...
Niwa, Maho, Patil, Christopher K, DeRisi, Joe, Walter, Peter
Abstract Background The unfolded protein response (UPR) allows intracellular feedback regulation that adjusts the protein-folding capacity of the endoplasmic reticulum (ER) according to need. The...
Christopher K. Patil, Hao Li, Peter Walter
The yeast unfolded protein response activates a large set of target genes, but a characterized element found in the promoter of one target, KAR2, cannot account for most targets. Using computational...
Christopher K. Patil, Hao Li, Peter Walter
Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates...
Gcn4p and Novel Upstream Activating (2004)
Sequences Regulate Targets, Christopher K. Patil, Hao Li, Peter Walter
this reporter gene under ER stress (Mori et al. 1992; Cox et al. 1993). As a positive control for UPR-dependent gene expression, we used a construct containing a triple repeat of the KAR2-derived...
2004 Niwa et Volume al. 6, Issue 1, Article R3 Open Access (2004)
Maho Niwa, Christopher K Patil, Joe Derisi, Peter Walter
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease
Cell, Vol. 101, 249--258, April 28, 2000, Copyright 2000 by Cell Press (2000)
Functional And Genomic, Christopher K. Patil, Lisa Wodicka, David J. Lockhart, Jonathan S. Weissman, Peter Walter
roarrays. Rather than (Cox and Walter, 1996; Mori et al., 1996; Sidrauski et al., 1996; Sidrauski and Walter, 1997), and ultimately regulating only ER-resident chaperones and phospholipid...
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
Patil, Christopher K, Li, Hao, Walter, Peter
Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates...
Niwa, Maho, Patil, Christopher K, DeRisi, Joe, Walter, Peter
Three different genome-scale screens indicate that the HAC1 mRNA is the only substrate for the Ire1 nuclease in yeast.
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
Patil, Christopher K, Li, Hao, Walter, Peter
Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates...
Niwa, Maho, Patil, Christopher K, DeRisi, Joe, Walter, Peter
Three different genome-scale screens indicate that the HAC1 mRNA is the only substrate for the Ire1 nuclease in yeast.
Coppé, Jean-Philippe, Patil, Christopher K, Rodier, Francis, Sun, Yu, Muñoz, Denise P, Goldstein, Joshua, ...
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to...