Christopher Torrens

Atorvastatin restores endothelial function in offspring of protein restricted rats in a cholesterol-independent manner (2009)

Torrens, Christopher, Kelsall, Christopher J., Hopkins, Laura A., Anthony, Frederick W., Curzen, Nick P., Hanson, Mark A.

Maternal protein restriction in rats leads to endothelial dysfunction and decreased NO bioavailability in the offspring. Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) are...

The effect of pre- and peri-conceptional undernutrition on arterial function in adult female sheep are vascular bed dependent (2009)

Torrens, Christopher, Snelling, Tristram H., Chau, Ryan, Shanmuganathan, Meena, Cleal, Jane K., Poore, Kirsten R., ...

The nutritional environment during development and even prior to conception may contribute to cardiovascular risk. In mature adult female sheep, we investigated the effect of preconceptional and...

Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease (2008)

Rodford, Joanne L., Torrens, Christopher, Siow, Richard C.M., Mann, Giovanni E., Hanson, Mark A., Clough, Geraldine F.

Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring (2008)

Watkins, Adam J., Wilkins, Adrian, Cunningham, Colm, Perry, V. Hugh, Seet, Meei J., Osmond, Clive, ...

Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease-related postnatal phenotype. To determine whether this sensitivity extended into oocyte...

Maternal low protein diet during oocyte maturation causes increased systolic blood pressure and abnormal behaviour in the mouse (2007)

Watkins, Adam, Torrens, Christopher, Cunningham, Colm, Wilkins, Adrian, Gray, Liam, Perry, Hugh, ...

Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood (2007)

Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...

The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...

Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood (2007)

Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...

The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...

Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations (2007)

Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A., Lillycrop, Karen A.

Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent...

The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies (2006)

Poston, Lucilla, Torrens, Christopher, Armitage, James A., Hanson, Mark A.

Folate supplementation during pregnancy improves offspring cardiovascular dysfunction Induced by protein restriction (2006)

Torrens, Christopher, Brawley, Lee, Anthony, Frederick W., Dance, Caroline S., Dunn, Rebecca, Jackson, Alan A., ...

Dietary protein restriction in the rat compromises the maternal cardiovascular adaptations to pregnancy and leads to raised blood pressure and endothelial dysfunction in the offspring. In this study...

Impaired endothelial-dependent vasodilation in old but not young female offspring of rats fed a protein restricted diet during pregnancy (2006)

Torrens, Christopher, Rodford, Joanne L., Wheeler, Timothy, Hanson, Mark A., Clough, Geraldine F.

In the rat, the restriction of dietary protein during pregnancy leads to raised blood pressure and impaired endothelium-dependent vasodilatation in the male offspring (Brawley et al. 2003). Ageing is...

Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function (2005)

Khan, Omar A., Torrens, Christopher, Noakes, David E., Poston, Lucilla, Hanson, Mark A., Green, Lucy R., ...

Objective: Previous studies in humans and animals have suggested that undernutrition in utero and in early post-natal life may lead to altered vascular function in a number of peripheral arteries. We...

Transgenerational programming of the cardiovascular system by protein restriction in pregnancy / (2004)

Torrens, Christopher.

Thesis (Ph.D.)--University of Southampton, 2004.

Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring (2003)

Brawley, Lee, Itoh, Shigeru, Torrens, Christopher, Barker, Alison, Bertram, Caroline, Poston, Lucilla, ...

It is established that dietary protein restriction of pregnant rats results in their offspring developing hypertension. However, to date no studies have investigated peripheral vascular function of...

Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring (2003)

Torrens, Christopher, Brawley, Lee, Barker, Alison C., Itoh, Shigeru, Poston, Lucilla, Hanson, Mark A.

Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects...

Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood

Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...

The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...

Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring

Torrens, Christopher, Brawley, Lee, Barker, Alison C, Itoh, Shigeru, Poston, Lucilla, Hanson, Mark A

Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects...

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring

Watkins, Adam J, Wilkins, Adrian, Cunningham, Colm, Perry, V Hugh, Seet, Meei J, Osmond, Clive, ...

Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease-related postnatal phenotype. To determine whether this sensitivity extended into oocyte...

Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease

Rodford, Joanne L, Torrens, Christopher, Siow, Richard C M, Mann, Giovanni E, Hanson, Mark A, Clough, Geraldine F

Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...