Chuan-Chu Chou

Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5 (1999)

Zhang, Ji, Kuvelkar, Reshma, Murgolo, Nicholas J., Taremi, S. Shane, Chou, Chuan-Chu, Wang, Peng, ...

mAb against human IL-5 inhibit pulmonary eosinophilia, tissue damage and airway hyper-reactivity in allergic animal models. Sch 55700 is a humanized, neutralizing anti-IL-5 antibody. To better...

Structure and humanization of a rat monoclonal Fab to human interleukin-5 (1996)

Cook, William J., Walter, Leigh J., Murgolo, Nicholas J., Chou, Chuan-Chu, Petro, Mary, Zavodny, Paul J., ...

The X-ray crystal structure of a rat monoclonal Fab JES1-39D10, raised against recombinant human interleukin-5, has been determined with the use of molecular replacement techniques and refined at 2.7...

Structure of messenger ribonucleic acids regulated during human myeloid cell differentiation /--by Chuan-Chu Chou. (1986)

Chou, Chuan-Chu.

Typescript (photocopy).

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, ...

We describe here the identification and properties of SCH-C (SCH 351125), a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. SCH-C, an oxime–piperidine compound, is a specific CCR5...

Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68

Jensen, Kristian K., Chen, Shu-Cheng, Hipkin, R. William, Wiekowski, Maria T., Schwarz, Martin A., Chou, Chuan-Chu, ...

Chemokine-binding proteins represent a novel class of antichemokine agents encoded by poxviruses and herpesviruses. One such protein is encoded by the M3 gene present in the murine gammaherpesvirus...

Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1

Strizki, Julie M., Tremblay, Cecile, Xu, Serena, Wojcik, Lisa, Wagner, Nicole, Gonsiorek, Waldemar, ...

Inhibiting human immunodeficiency virus type 1 (HIV-1) infection by blocking the host cell coreceptors CCR5 and CXCR4 is an emerging strategy for antiretroviral therapy. Currently, several novel...

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, ...

We describe here the identification and properties of SCH-C (SCH 351125), a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. SCH-C, an oxime–piperidine compound, is a specific CCR5...

Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68

Jensen, Kristian K., Chen, Shu-Cheng, Hipkin, R. William, Wiekowski, Maria T., Schwarz, Martin A., Chou, Chuan-Chu, ...

Chemokine-binding proteins represent a novel class of antichemokine agents encoded by poxviruses and herpesviruses. One such protein is encoded by the M3 gene present in the murine gammaherpesvirus...

Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1

Strizki, Julie M., Tremblay, Cecile, Xu, Serena, Wojcik, Lisa, Wagner, Nicole, Gonsiorek, Waldemar, ...

Inhibiting human immunodeficiency virus type 1 (HIV-1) infection by blocking the host cell coreceptors CCR5 and CXCR4 is an emerging strategy for antiretroviral therapy. Currently, several novel...

Pharmacological characterization of the chemokine receptor, hCCR1 in a stable transfectant and differentiated HL-60 cells: antagonism of hCCR1 activation by MIP-1β

Chou, Chuan-Chu, Fine, Jay S, Pugliese-Sivo, Catherine, Gonsiorek, Waldemar, Davies, Liza, Deno, Gregory, ...

C-C chemokine receptor-1 (CCR1) has been implicated in mediating a variety of inflammatory conditions including multiple sclerosis and organ rejection. Although originally referred to as the...