Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Willems, Laura, Reichelt, Melissa E., Molina, Jose G., Sun, Chun-Xiao, Chunn, Janci L., Ashton, Kevin J., ...
Objective Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Sun, Chun-Xiao, Haipek, Carrie, Scoles, Daniel R., Pulst, Stefan M., Giovannini, Marco, Komada, Masayuki, ...
Individuals with the neurofibromatosis 2 (NF2) inherited tumor predisposition syndrome are prone to the development of nervous system tumors, including schwannomas and meningiomas. The NF2 tumor...
Scoles, Daniel R., Nguyen, Vu D., Qin, Yun, Sun, Chun-Xiao, Morrison, Helen, Gutmann, David H., ...
Mutations in the neurofibromatosis 2 (NF2) gene with the resultant loss of expression of the NF2 tumor suppressor schwannomin are one of the most common causes of benign human brain tumors, including...
Gutmann, David H., Haipek, Carrie A., Burke, Stephen P., Sun, Chun-Xiao, Scoles, Daniel R., Pulst, Stefan M.
The neurofibromatosis 2 tumor suppressor protein, merlin or schwannomin, functions as a negative growth regulator; however, its mechanism of action is not known. In an effort to determine how merlin...
A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury
Sun, Chun-Xiao, Young, Hays W., Molina, Jose G., Volmer, Jonathan B., Schnermann, Jurgen, Blackburn, Michael R.
Adenosine is a signaling nucleoside that has been implicated in the regulation of asthma and chronic obstructive pulmonary disease. Adenosine signaling can serve both pro- and anti-inflammatory...
Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis
Ma, Bing, Blackburn, Michael R., Lee, Chun Geun, Homer, Robert J., Liu, Wei, Flavell, Richard A., ...
To define the factors that control the tissue effects of IL-4, we compared the effects of Tg IL-4 in Balb/c and C57BL/6 mice. In the former, IL-4 caused modest eosinophilic inflammation and mild...
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
Sun, Chun-Xiao, Zhong, Hongyan, Mohsenin, Amir, Morschl, Eva, Chunn, Janci L., Molina, Jose G., ...
Adenosine has been implicated in the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In vitro studies suggest that activation of the A2B adenosine...
A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury
Sun, Chun-Xiao, Young, Hays W., Molina, Jose G., Volmer, Jonathan B., Schnermann, Jurgen, Blackburn, Michael R.
Adenosine is a signaling nucleoside that has been implicated in the regulation of asthma and chronic obstructive pulmonary disease. Adenosine signaling can serve both pro- and anti-inflammatory...
Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis
Ma, Bing, Blackburn, Michael R., Lee, Chun Geun, Homer, Robert J., Liu, Wei, Flavell, Richard A., ...
To define the factors that control the tissue effects of IL-4, we compared the effects of Tg IL-4 in Balb/c and C57BL/6 mice. In the former, IL-4 caused modest eosinophilic inflammation and mild...
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
Sun, Chun-Xiao, Zhong, Hongyan, Mohsenin, Amir, Morschl, Eva, Chunn, Janci L., Molina, Jose G., ...
Adenosine has been implicated in the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In vitro studies suggest that activation of the A2B adenosine...
Csóka, Balázs, Németh, Zoltán H., Virág, László, Gergely, Pál, Leibovich, S. Joseph, Pacher, Pál, ...
We recently showed that A2A adenosine receptor activation by endogenous adenosine contributes to interleukin-10 (IL-10) production in polymicrobial sepsis. Here we investigated the molecular...
A3 Adenosine Receptor Signaling Contributes to Airway Mucin Secretion after Allergen Challenge
Young, Hays W. J., Sun, Chun-Xiao, Evans, Christopher M., Dickey, Burton F., Blackburn, Michael R.
Mucin hypersecretion is a prominent feature of obstructive airway diseases such as asthma. Clara cells conditionally produce mucin in response to inflammatory signals in a process termed mucous...