Clare E. Bryant

Induction of Proinflammatory Responses in the Human Monocytic Cell Line THP-1 by Campylobacter jejuni

Jones, Michael A., Tötemeyer, Sabine, Maskell, Duncan J., Bryant, Clare E., Barrow, Paul A.

Campylobacter jejuni can cause an enteritis that is associated with an acute inflammatory response at the gut epithelial surface. The signals inducing inflammation are unknown. C. jejuni can...

Toll-Like Receptor Expression in C3H/HeN and C3H/HeJ Mice during Salmonella enterica Serovar Typhimurium Infection

Tötemeyer, Sabine, Foster, Neil, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.

Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated...

Sublethal Infection of C57BL/6 Mice with Salmonella enterica Serovar Typhimurium Leads to an Increase in Levels of Toll-Like Receptor 1 (TLR1), TLR2, and TLR9 mRNA as Well as a Decrease in Levels of TLR6 mRNA in Infected Organs

Tötemeyer, Sabine, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.

Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their...

Induction of Proinflammatory Responses in the Human Monocytic Cell Line THP-1 by Campylobacter jejuni

Jones, Michael A., Tötemeyer, Sabine, Maskell, Duncan J., Bryant, Clare E., Barrow, Paul A.

Campylobacter jejuni can cause an enteritis that is associated with an acute inflammatory response at the gut epithelial surface. The signals inducing inflammation are unknown. C. jejuni can...

Toll-Like Receptor Expression in C3H/HeN and C3H/HeJ Mice during Salmonella enterica Serovar Typhimurium Infection

Tötemeyer, Sabine, Foster, Neil, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.

Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated...

Sublethal Infection of C57BL/6 Mice with Salmonella enterica Serovar Typhimurium Leads to an Increase in Levels of Toll-Like Receptor 1 (TLR1), TLR2, and TLR9 mRNA as Well as a Decrease in Levels of TLR6 mRNA in Infected Organs

Tötemeyer, Sabine, Kaiser, Pete, Maskell, Duncan J., Bryant, Clare E.

Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their...

Differential modulatory effects of Annexin 1 on nitric oxide synthase induction by lipopolysaccharide in macrophages

Smyth, Tomoko, Harris, Hayley J, Brown, Andrew, Tötemeyer, Sabine, Farnfield, Belinda A, Maskell, Duncan J, ...

Annexin-1 (ANXA1) is a glucocorticoid-regulated protein that modulates the effects of bacterial lipopolysaccharide (LPS) on macrophages. Exogenous administration of peptides derived from the...

A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins

Núñez Miguel, Ricardo, Wong, Joyce, Westoll, Julian F., Brooks, Heather J., O'Neill, Luke A.J., Gay, Nicholas J., ...

The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer...

Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif

Cook, Pamela, Tötemeyer, Sabine, Stevenson, Catherine, Fitzgerald, Katherine A, Yamamoto, Masahiro, Akira, Shizuo, ...

Salmonella enterica serovar typhimurium (S. typhimurium) is an intracellular pathogen that causes macrophage cell death by at least two different mechanisms. Rapid cell death is dependent on the...