Claude-James Soussy

First detection of plasmid-mediated quinolone resistance in the community setting and in hospitalized patients in Switzerland (2008)

Liassine, Nadia, Zulueta-Rodriguez, Patricia, Corbel, Céline, Lascols, Christine, Soussy, Claude-James, Cambau, Emmanuelle

Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates (2007)

Cattoir, Vincent, Poirel, Laurent, Rotimi, Vincent, Soussy, Claude-James, Nordmann, Patrice

Objectives To develop a rapid and reliable single-tube-based PCR technique for detecting simultaneously the plasmid-mediated quinolone resistance qnrA, qnrB and qnrS genes. Methods After multiple...

Emergence of a Streptococcus pneumoniae isolate resistant to streptogramins by mutation in ribosomal protein L22 during pristinamycin therapy of pneumococcal pneumonia (2007)

Cattoir, Vincent, Merabet, Lilia, Legrand, Patrick, Soussy, Claude-James, Leclercq, Roland

Objectives The aim of this study was to characterize the mechanism of resistance to macrolides and streptogramins of a Streptococcus pneumoniae strain isolated from blood cultures in an 80-year-old...

Prevalence of qnr genes in Salmonella in France (2007)

Cattoir, Vincent, Weill, François-Xavier, Poirel, Laurent, Fabre, Laëtitia, Soussy, Claude-James, Nordmann, Patrice

Objectives To detect the qnrA, qnrB and qnrS genes among Salmonella isolates received at the French National Reference Centre for Salmonella in Paris, France. Methods Antibiotic susceptibility was...

Prevalence of qnr genes in Salmonella in France (2007)

Cattoir, Vincent, Weill, François-Xavier, Poirel, Laurent, Fabre, Laëtitia, Soussy, Claude-James, Nordmann, Patrice

Objectives To detect the qnrA, qnrB and qnrS genes among Salmonella isolates received at the French National Reference Centre for Salmonella in Paris, France. Methods Antibiotic susceptibility was...

In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid (2006)

Cattoir, Vincent, Lesprit, Philippe, Lascols, Christine, Denamur, Erik, Legrand, Patrick, Soussy, Claude-James, ...

Objectives: To investigate quinolone resistance mechanisms in an Escherichia coli clinical isolate (Ar2) resistant to ofloxacin but susceptible to nalidixic acid selected after 10 days of ofloxacin...

In vivo selection during ofloxacin therapy of Escherichia coli with combined topoisomerase mutations that confer high resistance to ofloxacin but susceptibility to nalidixic acid (2006)

Cattoir, Vincent, Lesprit, Philippe, Lascols, Christine, Denamur, Erik, Legrand, Patrick, Soussy, Claude-James, ...

Objectives: To investigate quinolone resistance mechanisms in an Escherichia coli clinical isolate (Ar2) resistant to ofloxacin but susceptible to nalidixic acid selected after 10 days of ofloxacin...

Effect of pH on the susceptibility of Helicobacter pylori to the ketolide telithromycin (HMR 3647) and clarithromycin (2001)

Lascols, Christine, Bryskier, André, Soussy, Claude-James, Tankovic, Jacques

In-vitro activity of moxifloxacin against fluoroquinolone-resistant strains of aerobic Gram-negative bacilli and Enterococcus faecalis (1999)

Tankovic, Jacques, Bachoual, Rafik, Ouabdesselam, Saliha, Boudjadja, Azzedine, Soussy, Claude-James

MICs of the new fluoroquinolone, moxifloxacin, and those of ciprofloxacin, ofloxacin and sparfloxacin for 19 genetically characterized fluoroquinolone-resistant strains were determined by the agar...

Activity of RP 59500, a new parenteral semisynthetic streptogramin, against staphylococi with various mechanisms of resistance to macrolide-lincosamide-streptogramin antibiotics (1992)

Leclercq, Roland, Nantas, Liliane, Soussy, Claude-James, Duval, Jean

RP 59500 is a semisynthetic streptogramin (Sg) composed of two synergic components: RP 57669 and RP 54476. The activities of RP 59500, RP 57669 and RP 54476 were tested against 20 strains of...

Frequent Association between Alteration of the rdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori

Tankovic, Jacques, Lamarque, Dominique, Delchier, Jean-Charles, Soussy, Claude-James, Labigne, Agnes, Jenks, Peter J.

Mutations in the rdxA gene have been associated with the acquisition of resistance to metronidazole in Helicobacter pylori. This gene encodes an NADPH nitroreductase whose expression is necessary for...

Roles of gyrA Mutations in Resistance of Clinical Isolates and In Vitro Mutants of Bacteroides fragilis to the New Fluoroquinolone Trovafloxacin

Bachoual, Rafik, Dubreuil, Luc, Soussy, Claude-James, Tankovic, Jacques

We determined whether gyrA mutations were present in fluoroquinolone-resistant laboratory mutants derived from the Bacteroides fragilis reference strain ATCC 25285 and in clinical isolates of B....

Characterization of Mutations in the rpoB Gene That Confer Rifampin Resistance in Staphylococcus aureus

Aubry-Damon, Hélène, Soussy, Claude-James, Courvalin, Patrice

Mutations in the rifampin resistance-determining (Rif) regions of the rpoB gene of Staphylococcus aureus mutants obtained during therapy or in vitro were analyzed by gene amplification and...

Fast and Accurate Quantitative Detection of Helicobacter pylori and Identification of Clarithromycin Resistance Mutations in H. pylori Isolates from Gastric Biopsy Specimens by Real-Time PCR

Lascols, Christine, Lamarque, Dominique, Costa, Jean-Marc, Copie-Bergman, Christiane, Le Glaunec, Jeanne-Marie, Deforges, Lionel, ...

Rapid identification of patients infected with clarithromycin-resistant Helicobacter pylori without the need for culture can help to avoid useless prescriptions of clarithromycin. We developed and...

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Tankovic, Jacques, Lascols, Christine, Sculo, Quentin, Petit, Jean-Claude, Soussy, Claude-James

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and...

Frequent Association between Alteration of the rdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori

Tankovic, Jacques, Lamarque, Dominique, Delchier, Jean-Charles, Soussy, Claude-James, Labigne, Agnes, Jenks, Peter J.

Mutations in the rdxA gene have been associated with the acquisition of resistance to metronidazole in Helicobacter pylori. This gene encodes an NADPH nitroreductase whose expression is necessary for...

Roles of gyrA Mutations in Resistance of Clinical Isolates and In Vitro Mutants of Bacteroides fragilis to the New Fluoroquinolone Trovafloxacin

Bachoual, Rafik, Dubreuil, Luc, Soussy, Claude-James, Tankovic, Jacques

We determined whether gyrA mutations were present in fluoroquinolone-resistant laboratory mutants derived from the Bacteroides fragilis reference strain ATCC 25285 and in clinical isolates of B....

Characterization of Mutations in the rpoB Gene That Confer Rifampin Resistance in Staphylococcus aureus

Aubry-Damon, Hélène, Soussy, Claude-James, Courvalin, Patrice

Mutations in the rifampin resistance-determining (Rif) regions of the rpoB gene of Staphylococcus aureus mutants obtained during therapy or in vitro were analyzed by gene amplification and...

Fast and Accurate Quantitative Detection of Helicobacter pylori and Identification of Clarithromycin Resistance Mutations in H. pylori Isolates from Gastric Biopsy Specimens by Real-Time PCR

Lascols, Christine, Lamarque, Dominique, Costa, Jean-Marc, Copie-Bergman, Christiane, Le Glaunec, Jeanne-Marie, Deforges, Lionel, ...

Rapid identification of patients infected with clarithromycin-resistant Helicobacter pylori without the need for culture can help to avoid useless prescriptions of clarithromycin. We developed and...

Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori

Tankovic, Jacques, Lascols, Christine, Sculo, Quentin, Petit, Jean-Claude, Soussy, Claude-James

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and...

Bacterial Identification, Clinical Significance, and Antimicrobial Susceptibilities of Acinetobacter ursingii and Acinetobacter schindleri, Two Frequently Misidentified Opportunistic Pathogens▿

Dortet, Laurent, Legrand, Patrick, Soussy, Claude-James, Cattoir, Vincent

The species belonging to the Acinetobacter genus are currently reported as opportunistic pathogens in hospitalized patients with underlying predispositions. However, except for the Acinetobacter...

Novel Ambler Class A β-Lactamase LAP-1 and Its Association with the Plasmid-Mediated Quinolone Resistance Determinant QnrS1▿

Poirel, Laurent, Cattoir, Vincent, Soares, Ana, Soussy, Claude-James, Nordmann, Patrice

The plasmid-mediated quinolone resistance determinant QnrS1 was identified in non-clonally related Enterobacter cloacae isolates in association with a transferable narrow-spectrum β-lactam...

Vibrio splendidus as the Source of Plasmid-Mediated QnrS-Like Quinolone Resistance Determinants▿

Cattoir, Vincent, Poirel, Laurent, Mazel, Didier, Soussy, Claude-James, Nordmann, Patrice

A Plasmid-Borne Shewanella algae Gene, qnrA3, and Its Possible Transfer In Vivo between Kluyvera ascorbata and Klebsiella pneumoniae▿

Lascols, Christine, Podglajen, Isabelle, Verdet, Charlotte, Gautier, Valérie, Gutmann, Laurent, Soussy, Claude-James, ...

The plasmid-borne quinolone resistance gene qnrA1 is prevalent in multidrug-resistant Enterobacteriaceae. A chromosomally encoded homologue in Shewanella algae, qnrA3, has been described. We isolated...

Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.

Cattoir, Vincent, Poirel, Laurent, Aubert, Camille, Soussy, Claude-James, Nordmann, Patrice

Identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods.

The Pentapeptide Repeat Proteins MfpAMt and QnrB4 Exhibit Opposite Effects on DNA Gyrase Catalytic Reactions and on the Ternary Gyrase-DNA-Quinolone Complex▿ †

Mérens, Audrey, Matrat, Stéphanie, Aubry, Alexandra, Lascols, Christine, Jarlier, Vincent, Soussy, Claude-James, ...

MfpAMt and QnrB4 are two newly characterized pentapeptide repeat proteins (PRPs) that interact with DNA gyrase. The mfpAMt gene is chromosome borne in Mycobacterium tuberculosis, while qnrB4 is...