Claudine Chaouiya

Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novotrastuzumab resistance (2009)

Sahin, Özgür, Fröhlich, Holger, Löbke, Christian, Korf, Ulrike, Burmester, Sara, Majety, Meher, ...

Abstract Background In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic...

Qualitative Petri Net Modelling of Genetic Networks (2008)

Claudine Chaouiya, Elisabeth Remy, Denis Thieffry

Abstract. The complexity of biological regulatory networks calls for the development of proper mathematical methods to model their structures and to give insight in their dynamical behaviours. One...

Outline (2008)

Claudine Chaouiya, Dynamical Liveness

Petri nets for qualitative modelling

Petri net modelling of biological networks (2007)

Chaouiya, Claudine

Mathematical modelling is increasingly used to get insights into the functioning of complex biological networks. In this context, Petri nets (PNs) have recently emerged as a promising tool among the...

BMC Bioinformatics BioMed Central Poster presentation Logical modelling and analysis of the budding yeast cell cycle (2007)

Adrien Fauré, Claudine Chaouiya, Andrea Ciliberto, Denis Thieffry, Open Access

Biological background The budding yeast cell cycle core engine has been modelled in great detail, most notably by the groups of Béla Novak and John Tyson, using a differential formalism. Several...

Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle (2006)

Fauré, Adrien, Naldi, Aurélien, Chaouiya, Claudine, Thieffry, Denis

Motivation: To understand the behaviour of complex biological regulatory networks, a proper integration of molecular data into a full-fledge formal dynamical model is ultimately required. As most...

Qualitative modelling of genetic networks: From logical regulatory graphs to standard Petri nets (2004)

Claudine Chaouiya, Elisabeth Remy, Paul Ruet, Denis Thieffry

1 Introduction Regulatory networks are found at the core of all biological functions, from biochemical pathways, to gene regulation, and cell communication processes. Their complexity often defies...

D.: GINML: towards a GXL based format for logical regulatory networks and dynamical graphs. http://www.esil.univevry.fr/∼chaouiya/GINsim/ginml.html (2003)

Claudine Chaouiya, Aitor González González, Denis Thieffry

A flexible and rigorous logical formalism enabling the qualitative dynamical modelling of biological regulatory networks is described in [1]. This logical approach has been implemented in a Java...

Modelling and simulating the regulatory network specifying the Notch boundary between the dorsal and the ventral compartments of the wing imaginal disc (2003)

Aitor Gonz Alez, Aitor González González, Claudine Chaouiya, Denis Thieffry, Lucas Sánchez, Ap Fng, ...

vate the NOTCH signalling pathway. However SER is not able to activate NOTCH in the dorsal cells due to FRINGE (FNG) presence. Therefore SER activates only NOTCH in ventral cells near the boundary...

Dynamical Analysis of the Regulatory Network Defining the Dorsal–Ventral Boundary of the Drosophila Wing Imaginal Disc

González, Aitor, Chaouiya, Claudine, Thieffry, Denis

The larval development of the Drosophila melanogaster wings is organized by the protein Wingless, which is secreted by cells adjacent to the dorsal–ventral (DV) boundary. Two signaling processes...