Scientific Commons: Claus Scheidereit

Die Erkennungssequenzen von Steroidhormon-Rezeptoren an der DNA-Doppelhelix des regulatorischen Elements von Maus Mamma Tumorvirus und an weiteren Genpromotoren. (1985)

Scheidereit, Claus.

Marburg, Univ., Diss., 1985 (Nur als Mikrofiche f.d. Austausch).

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G0/G1-to-S-Phase Transition

Hinz, Michael, Krappmann, Daniel, Eichten, Alexandra, Heder, Andreas, Scheidereit, Claus, Strauss, Michael

Nuclear factor kappa B (NF-κB) has been implicated in the regulation of cell proliferation, transformation, and tumor development. We provide evidence for a direct link between NF-κB activity and...

Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex

Hehner, Steffen P., Hofmann, Thomas G., Ushmorov, Alexej, Dienz, Oliver, Lassam, Norman, ...

The phosphorylation of IκB by the multiprotein IκB kinase complex (IKC) precedes the activation of transcription factor NF-κB, a key regulator of the inflammatory response. Here we identified the...

Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα

Heissmeyer, Vigo, Krappmann, Daniel, Hatada, Eunice N., Scheidereit, Claus

p105 (NFKB1) acts in a dual way as a cytoplasmic IκB molecule and as the source of the NF-κB p50 subunit upon processing. p105 can form various heterodimers with other NF-κB subunits, including...

B-Cell Receptor- and Phorbol Ester-Induced NF-κB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's

Krappmann, Daniel, Patke, Alina, Heissmeyer, Vigo, Scheidereit, Claus

Antigen receptor signaling is known to activate NF-κB in lymphocytes. While T-cell-receptor-induced NF-κB activation critically depends on novel protein kinase C θ (PKCθ), the role of novel PKCs...

Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site

Hirano, Fuminori, Tanaka, Hirotoshi, Hirano, Yoshiko, Hiramoto, Masaki, Handa, Hiroshi, Makino, Isao, ...

Gene activation by NF-κB/Rel transcription factors is modulated by synergistic or antagonistic interactions with other promoter-bound transcription factors. For example, Sp1 sites are often found in...

Alternative Splicing Variants of IκBβ Establish Differential NF-κB Signal Responsiveness in Human Cells

Hirano, Fuminori, Chung, Mirra, Tanaka, Hirotoshi, Maruyama, Naoki, Makino, Isao, Moore, David D., ...

To release transcription factor NF-κB into the nucleus, the mammalian IκB molecules IκBα and IκBβ are inactivated by phosphorylation and proteolytic degradation. Both proteins contain conserved...

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-κB

Mathas, Stephan, Hinz, Michael, Anagnostopoulos, Ioannis, Krappmann, Daniel, Lietz, Andreas, Jundt, Franziska, ...

AP-1 family transcription factors have been implicated in the control of proliferation, apoptosis and malignant transformation. However, their role in oncogenesis is unclear and no recurrent...

Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation

Tegethoff, Sebastian, Behlke, Joachim, Scheidereit, Claus

The IκB kinase (IKK) complex mediates activation of transcription factor NF-κB by phosphorylation of IκB proteins. Its catalytic subunits, IKKα and IKKβ, require association with the regulatory...

The IκB Kinase Complex and NF-κB Act as Master Regulators of Lipopolysaccharide-Induced Gene Expression and Control Subordinate Activation of AP-1

Krappmann, Daniel, Wegener, Elmar, Sunami, Yoshiaki, Esen, Meral, Thiel, Andreas, Mordmuller, Benjamin, ...

Toll-like receptors (TLRs) recognize conserved products of microbial pathogens to initiate the innate immune response. TLR4 signaling is triggered upon binding of lipopolysaccharides (LPS) from...

Tissue-Specific Expression of a Splicing Mutation in the IKBKAP Gene Causes Familial Dysautonomia

Slaugenhaupt, Susan A., Blumenfeld, Anat, Gill, Sandra P., Leyne, Maire, Mull, James, Cuajungco, Math P., ...

Familial dysautonomia (FD; also known as “Riley-Day syndrome”), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is...

Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism

Mordmüller, Benjamin, Krappmann, Daniel, Esen, Meral, Wegener, Elmar, Scheidereit, Claus

The 'classical' NF-κB activation pathway proceeds via IκB kinase (IKK)-β/γ-mediated phosphorylation, induced ubiquitination and the degradation of small IκBs. An alternative, NF-κB-inducing...

A pervasive role of ubiquitin conjugation in activation and termination of IκB kinase pathways

Krappmann, Daniel, Scheidereit, Claus

The nuclear factor (NF)-κB pathway is a paradigm for gene expression control by ubiquitin-mediated protein degradation. In stimulated cells, phosphorylation by the IκB kinase (IKK) complex primes...