Mathews, Clayton E., Graser, Robert T., Savinov, Alexei, Serreze, David V., Leiter, Edward H.
Genetic analysis of autoimmune insulin-dependent diabetes mellitus (IDDM) has focused on genes controlling immune functions, with little investigation of innate susceptibility determinants expressed...
Mathews, Clayton E., Graser, Robert T., Savinov, Alexei, Serreze, David V., Leiter, Edward H.
Genetic analysis of autoimmune insulin-dependent diabetes mellitus (IDDM) has focused on genes controlling immune functions, with little investigation of innate susceptibility determinants expressed...
Apoptotic cells induce Mer tyrosine kinase–dependent blockade of NF-κB activation in dendritic cells
Sen, Pradip, Wallet, Mark A., Yi, Zuoan, Huang, Yingsu, Henderson, Michael, Mathews, Clayton E., ...
Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established by an encounter with apoptotic cells (ACs) and subsequent inhibition...
MerTK is required for apoptotic cell–induced T cell tolerance
Wallet, Mark A., Sen, Pradip, Flores, Rafael R., Wang, Yaming, Yi, Zuoan, Huang, Yingsu, ...
Self-antigens expressed by apoptotic cells (ACs) may become targets for autoimmunity. Tolerance to these antigens is partly established by an ill-defined capacity of ACs to inhibit antigen-presenting...
mt-Nd2a Suppresses Reactive Oxygen Species Production by Mitochondrial Complexes I and III*S⃞
Gusdon, Aaron M., Votyakova, Tatyana V., Mathews, Clayton E.
Reactive oxygen species (ROS) play a critical role in the pathogenesis of human diseases. A cytosine to adenine transversion in the mitochondrially encoded NADH dehydrogenase subunit 2 (mt-ND2,...
MerTK regulates thymic selection of autoreactive T cells
Wallet, Mark A., Flores, Rafael R., Wang, Yaming, Yi, Zuoan, Kroger, Charles J., Mathews, Clayton E., ...
T cell-mediated autoimmune diseases such as type 1 diabetes (T1D) are believed to be the result in part of inefficient negative selection of self-specific thymocytes. However, the events regulating...