Colin F. Arlett

Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene (2001)

Broughton, Bernard C., Berneburg, Mark, Fawcett, Heather, Taylor, Elaine M., Arlett, Colin F., Nardo, Tiziana, ...

The xeroderma pigmentosum group D (XPD) protein is a subunit of transcription factor TFIIH with DNA helicase activity. TFIIH has two functions, in basal transcription and nucleotide excision repair....

Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes (2000)

Petit-Frère, Corinne, Capulas, Emily, Lyon, Debbie A., Norbury, Christopher J., Lowe, Jillian E., Clingen, Peter H., ...

We have compared the induction of apoptosis and cytokine release by UVB and γ-radiation in primary (untransformed) and in two immortalized human epithelial/keratinocyte cell lines, HaCaT and KB (KB...

Frequencies of hprt- mutations and bcl-2 translocations in circulating human lymphocytes are correlated with United Kingdom sunlight records (1999)

Bentham, Graham, Wolfreys, Alison M., Liu, Yafei, Cortopassi, Gino, Green, Michael H.L., Arlett, Colin F., ...

Between 1983 and 1995 we have monitored human populations for evidence of exposure to environmental mutagens, taking blood samples to measure hprt– mutant frequency in T cells and more recently...

Repair of cyclobutane pyrimidine dimers in unstimulated human mononuclear cells is deficient at very low fluences of ultraviolet B and is not enhanced by addition of deoxyribonucleosides (1998)

Han, Ping, Clingen, Peter H., Lowe, Jillian E., Katsuya, Akiko, Arlett, Colin F., Green, Michael H. L.

Unstimulated human T lymphocytes are exquisitely sensitive to UVB irradiation. This hypersensitivity appears to relate to low deoxyribonucleotide pool sizes. They have also been reported to be...

Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals

Ahrens, Constanze, Grewe, Markus, Berneburg, Mark, Grether-Beck, Susanne, Quilliet, Xavier, Mezzina, Mauro, ...

Cells from patients with xeroderma pigmentosum complementation group D (XP-D) and most patients with trichothiodystrophy (TTD) are deficient in excision repair of ultraviolet (UV) radiation-induced...

Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene

Taylor, Elaine M., Broughton, Bernard C., Botta, Elena, Stefanini, Miria, Sarasin, Alain, Jaspers, Nicolaas G. J., ...

The xeroderma pigmentosum group D (XPD) protein has a dual function, both in nucleotide excision repair of DNA damage and in basal transcription. Mutations in the XPD gene can result in three...

Short tandem repeat profiling provides an international reference standard for human cell lines

Masters, John R., Thomson, Jim A., Daly-Burns, Bernadette, Reid, Yvonne A., Dirks, Wilhelm G., Packer, Phil, ...

Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a...

Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals

Ahrens, Constanze, Grewe, Markus, Berneburg, Mark, Grether-Beck, Susanne, Quilliet, Xavier, Mezzina, Mauro, ...

Cells from patients with xeroderma pigmentosum complementation group D (XP-D) and most patients with trichothiodystrophy (TTD) are deficient in excision repair of ultraviolet (UV) radiation-induced...

Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene

Taylor, Elaine M., Broughton, Bernard C., Botta, Elena, Stefanini, Miria, Sarasin, Alain, Jaspers, Nicolaas G. J., ...

The xeroderma pigmentosum group D (XPD) protein has a dual function, both in nucleotide excision repair of DNA damage and in basal transcription. Mutations in the XPD gene can result in three...

Short tandem repeat profiling provides an international reference standard for human cell lines

Masters, John R., Thomson, Jim A., Daly-Burns, Bernadette, Reid, Yvonne A., Dirks, Wilhelm G., Packer, Phil, ...

Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a...