Colm Cunningham

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease (2009)

Cunningham, Colm, Campion, Suzanne, Lunnon, Katie, Murray, Carol L, Woods, Jack F. C., Deacon, Robert M.J., ...

Background Chronic neurodegeneration results in microglial activation, but the contribution of inflammation to the progress of neurodegeneration remains unclear. We have shown that microglia express...

Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease (2008)

Adam J. Watkins, Elizabeth Ursell, Rose Panton, Thomas Papenbrock, Colm Cunningham, Adrian Wilkins, ...

Short title: Embryo responses to diet lead to adult disease Summary sentence: Maternal low protein diet induces compensatory responses within mouse early embryos to enhance growth and nutrient...

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring (2008)

Watkins, Adam J., Wilkins, Adrian, Cunningham, Colm, Perry, V. Hugh, Seet, Meei J., Osmond, Clive, ...

Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease-related postnatal phenotype. To determine whether this sensitivity extended into oocyte...

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration (2008)

Palin, Karine, Cunningham, Colm, Forse, Penny, Perry, V. Hugh, Platt, Nick

Axon loss in the CNS is characteristic of many neurodegenerative diseases but the mechanisms of axon degeneration are poorly understood. In particular, we know little of the inflammatory response...

Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease (2008)

Watkins, Adam J., Ursell, Elizabeth, Panton, Rose, Papenbrock, Thomas, Hollis, Lisa, Cunningham, Colm, ...

Poor maternal nutrition during pregnancy can alter postnatal phenotype and increase susceptibility to adult cardiovascular and metabolic diseases. However, underlying mechanisms are largely unknown....

Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study. (2008)

COAKLEY, DAVIS, COEN, ROBERT, CUNNINGHAM, COLM, MOLLOY, ANNE MARIE, SCOTT, JOHN MARTIN

PUBLISHED

Maternal low protein diet during oocyte maturation causes increased systolic blood pressure and abnormal behaviour in the mouse (2007)

Watkins, Adam, Torrens, Christopher, Cunningham, Colm, Wilkins, Adrian, Gray, Liam, Perry, Hugh, ...

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C) (2007)

Cunningham, Colm, Campion, Suzanne, Teeling, Jessica, Felton, Leigh, Perry, V.H.

Poly inosinic:poly cytidylic acid (poly I:C) is a synthetic double-stranded RNA and is a ligand for the Toll like receptor-3. This receptor is involved in the innate immune response to viral...

TGFβ1 regulates the inflammatory response during chronic neurodegeneration (2006)

Boche, Delphine, Cunningham, Colm, Docagne, Fabian, Scott, Helen, Perry, V. Hugh

The ME7 model of murine prion disease shows an atypical inflammatory response characterized by morphologically activated microglia and an anti-inflammatory cytokine profile with a marked expression...

TGF beta 1 regulates the inflammatory response during chronic neurodegeneration (2006)

Boche, Delphine, Cunningham, Colm, Docagne, Fabian, Scotta, Helen, Perry, V. Hugh

The ME7 model of murine prion disease shows an atypical inflammatory response characterized by morphologically activated microglia and an anti-inflammatory cytokine profile with a marked expression...

TGF beta 1 regulates the inflammatory response during chronic neurodegeneration (2006)

Boche, Delphine, Cunningham, Colm, Docagne, Fabian, Scott, Helen, Perry, V Hugh

The ME7 model of murine prion disease shows an atypical inflammatory response characterized by morphologically activated microglia and an anti-inflammatory cytokine profile with a marked expression...

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration (2005)

Cunningham, Colm, Wilcockson, David C., Campion, Suzanne, Lunnon, Katie, Perry, V. Hugh

The contribution of inflammation to the progression of eurodegenerative diseases such as Alzheimer’s, Parkinson’s, and prion diseases is poorly understood. Brain inflammation in animal models of...

Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease (2005)

Cunningham, Colm, Wilcockson, David C., Boche, Delphine, Perry, V. Hugh

Chronic neurodegenerative diseases such as prion disease and Alzheimer's disease (AD) are reported to be associated with microglial activation and increased brain and serum cytokines and acute-phase...

Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo (2003)

Boche, Delphine, Cunningham, Colm, Gauldie, Jack, Perry, V. Hugh

Ischemic preconditioning is a phenomenon that describes how a sublethal ischemic insult can induce tolerance to subsequent ischemia. This phenomenon has been observed after focal or global ischemia...

Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo (2003)

Boche, Delphine, Cunningham, Colm, Gauldie, Jack, Perry, V. Hugh

Ischemic preconditioning is a phenomenon that describes how a sublethal ischemic insult can induce tolerance to subsequent ischemia. This phenomenon has been observed after focal or global ischemia...

Atypical inflammation in the central nervous system in prion disease (2002)

Perry, V. Hugh, Cunningham, Colm, Boche, Delphine

The inflammatory response in prion diseases is dominated by microglial activation. Contrary to their profile in vitro none of the pro-inflammatory cytokines interleukin-1β, interleukin-6, or tumour...

Atypical inflammation in the central nervous system in prion disease (2002)

Perry, V. Hugh, Cunningham, Colm, Boche, Delphine

The inflammatory response in prion diseases is dominated by microglial activation. Contrary to their profile in vitro none of the pro-inflammatory cytokines interleukin-1[beta], interleukin-6, or...

Comparison of Inflammatory and Acute-Phase Responses in the Brain and Peripheral Organs of the ME7 Model of Prion Disease

Cunningham, Colm, Wilcockson, David C., Boche, Delphine, Perry, V. Hugh

Chronic neurodegenerative diseases such as prion disease and Alzheimer's disease (AD) are reported to be associated with microglial activation and increased brain and serum cytokines and acute-phase...

Comparison of Inflammatory and Acute-Phase Responses in the Brain and Peripheral Organs of the ME7 Model of Prion Disease

Cunningham, Colm, Wilcockson, David C., Boche, Delphine, Perry, V. Hugh

Chronic neurodegenerative diseases such as prion disease and Alzheimer's disease (AD) are reported to be associated with microglial activation and increased brain and serum cytokines and acute-phase...

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

Cunningham, Colm, Campion, Suzanne, Lunnon, Katie, Murray, Carol L., Woods, Jack F.C., Deacon, Robert M.J., ...

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring

Watkins, Adam J, Wilkins, Adrian, Cunningham, Colm, Perry, V Hugh, Seet, Meei J, Osmond, Clive, ...

Early embryonic development is known to be susceptible to maternal undernutrition, leading to a disease-related postnatal phenotype. To determine whether this sensitivity extended into oocyte...