Coralie VACHER

Rapamycin pre-treatment protects against apoptosis (2006)

Ravikumar, Brinda, Berger, Zdenek, Vacher, Coralie, O'Kane, Cahir J., Rubinsztein, David C.

Macroautophagy (generally referred to as autophagy) mediates the bulk degradation of cytoplasmic contents, including proteins and organelles, in lysosomes. Rapamycin, a lipophilic, macrolide...

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles (2006)

Underwood, Benjamin R., Broadhurst, David, Dunn, Warwick B., Ellis, David I., Michell, Andrew W., Vacher, Coralie, ...

There has been considerable progress recently towards developing therapeutic strategies for Huntington's disease (HD), with several compounds showing beneficial effects in transgenic mouse models....

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles (2006)

Underwood, Benjamin R., Broadhurst, David, Dunn, Warwick B., Ellis, David I., Michell, Andrew W., Vacher, Coralie, ...

There has been considerable progress recently towards developing therapeutic strategies for Huntington's disease (HD), with several compounds showing beneficial effects in transgenic mouse models....

Rapamycin pre-treatment protects against apoptosis (2006)

Ravikumar, Brinda, Berger, Zdenek, Vacher, Coralie, O'Kane, Cahir J, Rubinsztein, David C

Macroautophagy (generally referred to as autophagy) mediates the bulk degradation of cytoplasmic contents, including proteins and organelles, in lysosomes. Rapamycin, a lipophilic, macrolide...

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease (2005)

Vacher, Coralie, Garcia-Oroz, Lourdes, Rubinsztein, David C.

Huntington's disease is a devastating neurodegenerative condition associated with the formation of intraneuronal aggregates by mutant huntingtin. Aggregate formation is a property shared by the nine...

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease (2005)

Vacher, Coralie, Garcia-Oroz, Lourdes, Rubinsztein, David C

Huntington's disease is a devastating neurodegenerative condition associated with the formation of intraneuronal aggregates by mutant huntingtin. Aggregate formation is a property shared by the nine...

Effects of O-2 supersaturation on metabolism and growth in juvenile turbot (Scophthalmus maximus L.) (2002)

PERSON, Jeannine, PICHAVANT, Karine, VACHER, Coralie, LE BAYON, Nicolas, SEVERE, Armelle, BOEUF, Gilles

Effects of O-2 supersaturation on metabolism and growth were studied in juvenile turbot (Scophthalmus maximus L.). When fish were reared for 30 days in water containing O-2 at 147% or 223% air...

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

Luo, Shouqing, Vacher, Coralie, Davies, Janet E., Rubinsztein, David C.

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the huntingtin (htt) protein. Mutant htt toxicity is exposed after htt cleavage by...