Genomic and epigenetic evidence for oxytocin receptor deficiency in autism (2009)
Gregory, Simon G, Connelly, Jessica J, Towers, Aaron J, Johnson, Jessica, Biscocho, Dhani, Markunas, Christina A, ...
Abstract Background Autism comprises a spectrum of behavioral and cognitive disturbances of childhood development and is known to be highly heritable. Although numerous approaches have been used to...
Tissue-specific variation in DNA methylation levels along human chromosome 1 (2009)
De Bustos, Cecilia, Ramos, Edward, Young, Janet M, Tran, Robert K, Menzel, Uwe, Langford, Cordelia F, ...
Abstract Background DNA methylation is a major epigenetic modification important for regulating gene expression and suppressing spurious transcription. Most methods to scan the genome in different...
Bruce, Alexander W., López-Contreras, Andrés J., Flicek, Paul, Down, Thomas A., Dhami, Pawandeep, Dillon, Shane C., ...
The molecular events that contribute to, and result from, the in vivo binding of transcription factors to their cognate DNA sequence motifs in mammalian genomes are poorly understood. We demonstrate...
Thomas, Rachael, Duke, Shannon E., Bloom, Stephanie K., Breen, Tessa E., Young, Andrea C., Feiste, Erika, ...
The generation of a 7.5× dog genome assembly provides exciting new opportunities to interpret tumor-associated chromosome aberrations at the biological level. We present a genomic microarray for...
The landscape of histone modifications across 1% of the human genome in five human cell lines (2007)
Koch, Christoph M., Andrews, Robert M., Flicek, Paul, Dillon, Shane C., Karaöz, Ulas, Clelland, Gayle K., ...
We generated high-resolution maps of histone H3 lysine 9/14 acetylation (H3ac), histone H4 lysine 5/8/12/16 acetylation (H4ac), and histone H3 at lysine 4 mono-, di-, and trimethylation (H3K4me1,...
Rada-Iglesias, Alvaro, Enroth, Stefan, Ameur, Adam, Koch, Christoph M., Clelland, Gayle K., Respuela-Alonso, Patricia, ...
Butyrate is a histone deacetylase inhibitor (HDACi) with anti-neoplastic properties, which theoretically reactivates epigenetically silenced genes by increasing global histone acetylation. However,...
Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors (2005)
Thomas, Rachael, Scott, Allyson, Langford, Cordelia F., Fosmire, Susan P., Jubala, Cristan M., Lorentzen, Travis D., ...
Recognition of the domestic dog as a model for the comparative study of human genetic traits has led to major advances in canine genomics. The pathophysiological similarities shared between many...
Thesis (Ph.D.)--Open University, 2003.
Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors
Thomas, Rachael, Scott, Allyson, Langford, Cordelia F., Fosmire, Susan P., Jubala, Cristan M., Lorentzen, Travis D., ...
Recognition of the domestic dog as a model for the comparative study of human genetic traits has led to major advances in canine genomics. The pathophysiological similarities shared between many...
Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors
Thomas, Rachael, Scott, Allyson, Langford, Cordelia F., Fosmire, Susan P., Jubala, Cristan M., Lorentzen, Travis D., ...
Recognition of the domestic dog as a model for the comparative study of human genetic traits has led to major advances in canine genomics. The pathophysiological similarities shared between many...
The landscape of histone modifications across 1% of the human genome in five human cell lines
Koch, Christoph M., Andrews, Robert M., Flicek, Paul, Dillon, Shane C., Karaöz, Ulaş, Clelland, Gayle K., ...
We generated high-resolution maps of histone H3 lysine 9/14 acetylation (H3ac), histone H4 lysine 5/8/12/16 acetylation (H4ac), and histone H3 at lysine 4 mono-, di-, and trimethylation (H3K4me1,...
Rada-Iglesias, Alvaro, Enroth, Stefan, Ameur, Adam, Koch, Christoph M., Clelland, Gayle K., Respuela-Alonso, Patricia, ...
Butyrate is a histone deacetylase inhibitor (HDACi) with anti-neoplastic properties, which theoretically reactivates epigenetically silenced genes by increasing global histone acetylation. However,...
Bruce, Alexander W., López-Contreras, Andrés J., Flicek, Paul, Down, Thomas A., Dhami, Pawandeep, Dillon, Shane C., ...
The molecular events that contribute to, and result from, the in vivo binding of transcription factors to their cognate DNA sequence motifs in mammalian genomes are poorly understood. We demonstrate...
A HaemAtlas: characterizing gene expression in differentiated human blood cells
Watkins, Nicholas A., Gusnanto, Arief, De Bono, Bernard, De, Subhajyoti, Miranda-Saavedra, Diego, Hardie, Debbie L., ...
Hematopoiesis is a carefully controlled process that is regulated by complex networks of transcription factors that are, in part, controlled by signals resulting from ligand binding to cell-surface...