Decourty, Laurence, Saveanu, Cosmin, Rappsilber, Juri, Jacquier, Alain, ...
A genome-wide screen for synthetic lethal (SL) interactions with loss of the nuclear exosome cofactors Rrp47/Lrp1 or Air1 identified 3' --> 35' exonucleases, the THO complex required for mRNP...
Olivier Garcia, Cosmin Saveanu, Melissa Cline, Micheline Fromont-racine, Alain Jacquier, Benno Schwikowski, ...
Summary: We have implemented a graph layout algorithm that exposes Gene Ontology (GO) class structure on the network nodes. It can be used in conjunction with BiNGO plug-in to Cytoscape, which finds...
Lebreton, Alice, Rousselle, Jean-Claude, Lenormand, Pascal, Namane, Abdelkader, Jacquier, Alain, Fromont-Racine, Micheline, ...
During the highly conserved process of eukaryotic ribosome formation, RNA follows a maturation path with well-defined, successive intermediates that dynamically associate with many pre-ribosomal...
Cytoplasmic Recycling of 60S Preribosomal Factors Depends on the AAA Protein Drg1 (2007)
Pertschy, Brigitte, Saveanu, Cosmin, Zisser, Gertrude, Lebreton, Alice, Tengg, Martin, Jacquier, Alain, ...
Allelic forms of DRG1/AFG2 confer resistance to the drug diazaborine, an inhibitor of ribosome biogenesis in Saccharomyces cerevisiae. Our results show that the AAA-ATPase Drg1 is essential for 60S...
Garcia, Olivier, Saveanu, Cosmin, Cline, Melissa, Fromont-Racine, Micheline, Jacquier, Alain, Schwikowski, Benno, ...
Summary: We have implemented a graph layout algorithm that exposes Gene Ontology (GO) class structure on the network nodes. It can be used in conjunction with BiNGO plug-in to Cytoscape, which finds...
Gene Ontology-based layout and coloring (2006)
Olivier Garcia, Cosmin Saveanu, Melissa Cline, Micheline Fromont-racine, Alain Jacquier, Benno Schwikowski, ...
doi:10.1093/bioinformatics/btl605 GOlorize: a Cytoscape plug-in for network visualization with
Saveanu, Cosmin, Miron, Simona, Borza, Tudor, Craescu, Constantin T., Labesse, Gilles, Gagyi, Cristina, ...
Structural genomics is a new approach in functional assignment of proteins identified via whole-genome sequencing programs. Its rationale is that nonhomologous proteins performing similar or related...
Genetic and Biochemical Characterization of Salmonella enterica Serovar Typhi Deoxyribokinase
Tourneux, Lise, Bucurenci, Nadia, Saveanu, Cosmin, Kaminski, Pierre Alexandre, Bouzon, Madeleine, Pistotnik, Elisabeth, ...
We identified in the genome of Salmonella enterica serovar Typhi the gene encoding deoxyribokinase, deoK. Two other genes, vicinal to deoK, were determined to encode the putative deoxyribose...
Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
Saveanu, Cosmin, Bienvenu, David, Namane, Abdelkader, Gleizes, Pierre-Emmanuel, Gas, Nicole, Jacquier, Alain, ...
Eukaryotic ribosome maturation depends on a set of well ordered processing steps. Here we describe the functional characterization of yeast Nog2p (Ynr053cp), a highly conserved nuclear protein. Nog2p...
Sequential Protein Association with Nascent 60S Ribosomal Particles
Saveanu, Cosmin, Namane, Abdelkader, Gleizes, Pierre-Emmanuel, Lebreton, Alice, Rousselle, Jean-Claude, Noaillac-Depeyre, Jacqueline, ...
Ribosome biogenesis in eukaryotes depends on the coordinated action of ribosomal and nonribosomal proteins that guide the assembly of preribosomal particles. These intermediate particles follow a...
The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast
Léger-Silvestre, Isabelle, Milkereit, Philipp, Ferreira-Cerca, Sébastien, Saveanu, Cosmin, Rousselle, Jean-Claude, Choesmel, Valérie, ...
We have conducted a genetic screen in order to identify ribosomal proteins of Saccharomyces cerevisiae involved in nuclear export of the small subunit precursors. This has led us to distinguish...
Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression
Huntzinger, Eric, Boisset, Sandrine, Saveanu, Cosmin, Benito, Yvonne, Geissmann, Thomas, Namane, Abdelkader, ...
Staphylococcus aureus RNAIII is one of the largest regulatory RNAs, which controls several virulence genes encoding exoproteins and cell-wall-associated proteins. One of the RNAIII effects is the...
Genetic and Biochemical Characterization of Salmonella enterica Serovar Typhi Deoxyribokinase
Tourneux, Lise, Bucurenci, Nadia, Saveanu, Cosmin, Kaminski, Pierre Alexandre, Bouzon, Madeleine, Pistotnik, Elisabeth, ...
We identified in the genome of Salmonella enterica serovar Typhi the gene encoding deoxyribokinase, deoK. Two other genes, vicinal to deoK, were determined to encode the putative deoxyribose...
Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps
Saveanu, Cosmin, Bienvenu, David, Namane, Abdelkader, Gleizes, Pierre-Emmanuel, Gas, Nicole, Jacquier, Alain, ...
Eukaryotic ribosome maturation depends on a set of well ordered processing steps. Here we describe the functional characterization of yeast Nog2p (Ynr053cp), a highly conserved nuclear protein. Nog2p...
Sequential Protein Association with Nascent 60S Ribosomal Particles
Saveanu, Cosmin, Namane, Abdelkader, Gleizes, Pierre-Emmanuel, Lebreton, Alice, Rousselle, Jean-Claude, Noaillac-Depeyre, Jacqueline, ...
Ribosome biogenesis in eukaryotes depends on the coordinated action of ribosomal and nonribosomal proteins that guide the assembly of preribosomal particles. These intermediate particles follow a...
The ribosomal protein Rps15p is required for nuclear exit of the 40S subunit precursors in yeast
Léger-Silvestre, Isabelle, Milkereit, Philipp, Ferreira-Cerca, Sébastien, Saveanu, Cosmin, Rousselle, Jean-Claude, Choesmel, Valérie, ...
We have conducted a genetic screen in order to identify ribosomal proteins of Saccharomyces cerevisiae involved in nuclear export of the small subunit precursors. This has led us to distinguish...
Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression
Huntzinger, Eric, Boisset, Sandrine, Saveanu, Cosmin, Benito, Yvonne, Geissmann, Thomas, Namane, Abdelkader, ...
Staphylococcus aureus RNAIII is one of the largest regulatory RNAs, which controls several virulence genes encoding exoproteins and cell-wall-associated proteins. One of the RNAIII effects is the...
Saveanu, Cosmin, Rousselle, Jean-Claude, Lenormand, Pascal, Namane, Abdelkader, Jacquier, Alain, Fromont-Racine, Micheline
Ribosome biogenesis is driven by a large number of preribosomal factors that associate with and dissociate from the preribosomal particles along the maturation pathway. We have previously shown that...
A functional network involved in the recycling of nucleocytoplasmic pre-60S factors
Lebreton, Alice, Saveanu, Cosmin, Decourty, Laurence, Rain, Jean-Christophe, Jacquier, Alain, Fromont-Racine, Micheline
Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the...
Cytoplasmic Recycling of 60S Preribosomal Factors Depends on the AAA Protein Drg1▿ †
Pertschy, Brigitte, Saveanu, Cosmin, Zisser, Gertrude, Lebreton, Alice, Tengg, Martin, Jacquier, Alain, ...
Allelic forms of DRG1/AFG2 confer resistance to the drug diazaborine, an inhibitor of ribosome biogenesis in Saccharomyces cerevisiae. Our results show that the AAA-ATPase Drg1 is essential for 60S...
Saveanu, Cosmin, Miron, Simona, Borza, Tudor, Craescu, Constantin T., Labesse, Gilles, Gagyi, Cristina, ...
Structural genomics is a new approach in functional assignment of proteins identified via whole-genome sequencing programs. Its rationale is that nonhomologous proteins performing similar or related...
Lebreton, Alice, Rousselle, Jean-Claude, Lenormand, Pascal, Namane, Abdelkader, Jacquier, Alain, Fromont-Racine, Micheline, ...
During the highly conserved process of eukaryotic ribosome formation, RNA follows a maturation path with well-defined, successive intermediates that dynamically associate with many pre-ribosomal...
Decourty, Laurence, Saveanu, Cosmin, Zemam, Kenza, Hantraye, Florence, Frachon, Emmanuel, Rousselle, Jean-Claude, ...
Describing at a genomic scale how mutations in different genes influence one another is essential to the understanding of how genotype correlates with phenotype and remains a major challenge in...
Milligan, Laura, Decourty, Laurence, Saveanu, Cosmin, Rappsilber, Juri, Ceulemans, Hugo, Jacquier, Alain, ...
A genome-wide screen for synthetic lethal (SL) interactions with loss of the nuclear exosome cofactors Rrp47/Lrp1 or Air1 identified 3′→5′ exonucleases, the THO complex required for mRNP...